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| 1 | Paraoxonase gene cluster variations associated with coronary heart disease in Chinese Han women显示文摘Background The oxidative modification of low-density lipoprotein in the artery wall is currently believed to be central to the pathogenesis of atherosclerosis. Paraoxonase (PON1), an enzyme located on high-density lipoprotein (HDL), can prevent low-density lipoprotein (LDL) from oxidation at a certain extent. Recent studies show two other members of paraoxonase gene family, PON2 and PON3, possess antioxidant properties similar to PON1. The aim of the present study was to explore the role of PON gene cluster on coronary heart disease (CHD) in Chinese Han women.Methods Seven polymorphisms including PON1 -107C>T, -162G>A, -831G>A, R160G, Q192R, PON2 S311C, and PON3 -133C>A were genotyped in 184 female patients with CHD and 239 female controls. The plasma PON1 activity toward phenylacetate was determined in 50 cases and 50 controls randomly selected. Results The plasma PON1 activities were significantly lower in cases than in controls. Individual SNP analysis showed that cases had significantly higher frequencies of PON1 -107T, -831G and PON2 311S alleles than controls. The genotype distributions of -107C>T were also significantly different between two groups. The odds ratios for the development of CHD were 1.66 for -107TC carriers and 2.0 for -107TT carriers, compared with (-107CC) carriers. Haplotype analyses showed that the distributions of haplotypes comprised of PON1 -107C>T and PON2 S311C were significantly different between cases and controls, with cases having higher frequency of T-S haplotype (44.8% vs. 36.3%, P=0.013). The T-S haplotype remained significantly associated with CHD after adjusting environmental risk factors (P=0.0069).Conclusions This association study suggested that lower plasma PON1 activity increased the risk of CHD in Chinese woman, which may be mediated by the higher frequency of -107T allele in cases. Haplotype analyses indicated that there might be some synergistic effects between the PON1 -107C>T and PON2 S311C polymorphisms. | SUShao-yong CHENJian-hong HUANGJian-feng WANGXiao-ling ZHAOJian-gong SHENYan QIANGBo-qin GUDong-feng | 2005 | Chinese Medical Journal2005，，14： | 15 |
| 2 | ELECTRONIC STRUCTURES OF (CdSe)_n/(ZnSe)_m STRAINED-LAYER SUPERLATTICES显示文摘The electronic structures of (CdSe)n/(ZnSe)m strained-lager soperfattice (SLS) were investigated by the recursion method in the tight-bindiop opproximation. The total,local, and partial density of states were calculated for n=1, m=5.The total density of states (TDOS) for bulk CdSe, ZnSe and n=1, 3, m=1, 3, 5, for SLS were investigated.Fermi energy, the band gap, the valence of an atom, and the ionization potential and the electron affinity were discassed. | HL. Huang J.H Xing G.L. Liu and G.Y Zhang(Department of Electrouic Science and Engineering, Liaoning University Shenyang 110036, China)(Department of Physics, Liaoning University Shenyang 110036, China)(Shenyang Polytechnic University Shenyan 110023, Chin | 1997 | Acta Metallurgica Sinica(English Letters)1997，10，1： | 2 |
| 3 | FABRICATION OF Ti/SiC MMCs BY VACUUM HOT PRESSING WITH AID OF HYDROGEN显示文摘In order to alleviate the severe interface reaction, which is likely to occur during the fabrication of continuous SiC fiber reinforced titanium matrix composite, hydrogen was temporarily introduced in the fabrication to lower the consolidation temperature of Ti/SiC composites in the present work. Effects of different fabrication conditions, with or without hydrogen, on the bonding state and the matrix microstructure were investigated. In-situ hydrogenation method was found to larpely improve the interface bonding of the composite, and full consolidation could be achieved at 750 or even 700° C more than 100°C lower than the normal fabrication temperature of Ti/SiC composite, which consequently reduced the interfacial reaction layer between Ti matrix and SiC fiber. Different hydrogenation condition led to different matrix microstructure. In order to avoid the embrittling effect of residual hydrogen on the composite,Ti/SiC composite needs to be held in vacuum at the fabrication temperature for longer time after consolidation. | C.H. Zhou K. Yang and Y.X. Lu (Liaoning Key Lab for Hydrogen and Materich, Institute of Metal Research, The Chinese Academy of Sciences, Shenyan 110015, China) | 1998 | Acta Metallurgica Sinica(English Letters)1998，11，4： | 2 |
| 4 | Positron Annihilation Study on the Microstructural Stability in Rapidly Solidified Al_(92.3)Fe_(4.3)V_(0.7)Si_(1.7)Mm_(1.0) Alloy显示文摘Rapidly solidified Al92.3Fe4.3V0.7Si1.7Mm1.0 alloy has been studied by positron lifetime spectroscopy and the variations on the intedecial defects with the annealing temperature were revealed by an analysis of the lifetime results. The intedece characteristics derived from the positron-lifetime results could be used to give a satisfactory interpretation of the dependence of mechanical properties on the annealing | Wei JIA Meikuang Tseng and Jianqiang WANG(Dept. of Material Science, Northeastern University Shenyang 110006, China)Liangyue XIONG and Yelong CHU(International Ceoter for Materials Physics, Institute of Metal Research, Chinese Academy of Sciences,Shenyan | 1998 | Journal of Materials Science & Technology1998，14，2： | 1 |
| 5 | Electrode Design of Cylindrical Coplanar-grid CdZnTe Detector by Finite Element Methods显示文摘Cylindrical coplanar-grid configurations,which offer a lot of advantages over established designs,can effectively overcome the problem of poor hole collection.Finite element analysis is utilized for simulating the potential distribution of the cylindrical coplanar-grid detector under different models by varying the widths of grid and pitch of electrodes. In addition, a modified grid pattern has been discussed to improve the weighting potential match between two grids. In this way, the geometry of electrodes for cylindrical coplanar-grid detectors is optimized. | JINWei SANGWen-bin ZHANGQi MINJia-Hua SHENYan | 2004 | Semiconductor Photonics and Technology2004，10，1： | 1 |
| 6 | Simulated Annealing for Earliness/Tardiness Production Planning Model | LI Ying\|juan\+1,\ WANG Ding\|wei\+2 1. Department of Industry and Business Administration, Shenyang University Shenyang 110013,China 2. Department of Systems Engineering, College of Information Science and Engineering,Northeastern University,Shenyan | 2000 | Systems Science and Systems Engineering2000，10，1： | 1 |
| 7 | Improved genetic algorithm with two-level approximation for truss topology optimization显示文摘 | Li Dongfang Chen Shenyan Huang Hai | 2014 | Structural and Multidisciplinary Optimization(S1615-147X)2014，49，5： | 1 |
| 8 | 1 H NMR studies of starch–water interactions during microwave heating显示文摘 | Daming Fan Shenyan Ma Liyun Wang Hefei Zhao Jianxin Zhao Hao Zhang Wei Chen | 2013 | Carbohydrate Polymers2013，，2： | 1 |
| 9 | Characteristics of Faigue Crack Initiation in Ti-5Al-4Sn-2Zr-1Mo-0.7Nd-0.25Si Alloy显示文摘The characteristics of fatigue crack initiation in Ti-5AI-4Sn-2Zr1Mo-O.7Nd-O.25Si alloy wereStudied. Two modes Of fatigue crack initiation were found. The Nd-rich phase particles displaybetter resistance to fatigue crack initiation than the matrix at lower stress. | Jiafeng LEP Yuyin LIU Shaoxuan GUAN Qingjiang WANG Zhongguang WANG Dong LI and Zhuangqi HU(State Key Lab. for Fatigue and Fracture of Materials, Institute of Metal Research, Chinese Academy of Sciences,Shenyan 110015, China) | 1997 | Journal of Materials Science & Technology1997，13，3： | 0 |
| 10 | Application of Nanomaterials in the Rapid Detection of Pathogenic Microorganisms显示文摘Pathogenic microorganisms can cause infectious diseases in the human body and cause harm to humans.Under the continuous changes of human life style,sudden infectious diseases and sudden pathogenic microbial contamination in food have brought great challenges to human health.Traditional pathogenic microorganism detection is mainly carried out in laboratories with low speed,and requires experienced operators,which greatly affects the detection efficiency,and real-time monitoring cannot be achieved in the face of epidemics or food contamination.In response to these new situations,new on-site rapid detection methods have become a must,but to achieve the purpose of on-site rapid and immediate detection,higher requirements have been put forward to sensitivity and specificity.Due to their special photoelectric properties and adsorption properties,nanomaterials have gradually been applied in on-site rapid detection methods such as biosensors,and some substantial progress has been made.In this study,we introduced the actual application of nanomaterials in testing and their applications in on-site rapid testing,and made some prospects for the development of on-site rapid testing methods. | Shenyan SHI Xiaojuan NIE Dong HUANG Danni ZHAO Jiazhen MEI Tao LI Liyuan ZHANG Rui QIAN Peng LYU | 2021 | Agricultural Biotechnology2021，10，3： | 0 |
| 11 | Experimental Study of UDS Solvents for Purifying Highly Sour Natural Gas at Industrial Side-stream Plant显示文摘The desulfurization performance of the UDS solvents was investigated at an industrial side-stream plant and was compared with that of MDEA solvent.A mass transfer performance model was employed for explaining the COS absorption into different solvents.Meanwhile,the regeneration performance of the UDS solvents was evaluated in side-stream tests.Results indicate that under the conditions covering an absorption temperature of 40℃,a pressure of 8.0 MPa,and a gas to liquid volume ratio(V/L)of around 230,the H2S content in purified gas can be reduced to 4.2 mg/m3 and 0 by using solvents UDS-II and UDS-III,respectively.Moreover,the total sulfur content in both purified gases is less than 80 mg/m3.As a result,the UDS-III solvent shows by 30 percentage points higher in COS removal efficiency than MDEA.In addition,the total volume mass transfer coefficient of UDS solvent is found to be twice higher than that of MDEA.Furthermore,the UDS solvents exhibit satisfactory thermal stability and regeneration performance. | Ke Yuan Shen Benxian Sun Hui Liu Jichang Liu Lu Xu Shenyan | 2016 | China Petroleum Processing & Petrochemical Technology2016，18，1： | 0 |
| 12 | Quantitative Evaluation of Aldo-keto Reductase Expression in Hepatocellular Carcinoma (HCC) Cell Lines显示文摘The involvement of aldo-keto reductases(AKRs) in tumorigenesis is widely reported,but their roles in the pathological process are not generally recognized due to inconsistent measurements of their expression.To overcome this problem,we simultaneously employed real-time PCR to examine gene expression and multiple reaction monitoring(MRM) of mass spectrometry(MS) to examine the protein expression of AKRs in fve different hepatic cell lines.These include one relatively normal hepatic cell line,L-02,and four hepatocellular carcinoma(HCC) cell lines,HepG2,HuH7,BEL7402 and SMMC7721.The results of real-time PCR showed that expression of genes encoding the AKR1C family members rather than AKR1A and AKR1B was associated with tumor,and most of genes encoding AKRs were highly expressed in HuH7.Similar observations were obtained through MRM.Different from HuH7,the protein abundance of AKR1A and AKR1B was relatively consistent among the other four hepatic cell lines,while protein expression of AKR1C varied signifcantly compared to L-02.Therefore,we conclude that the abundant distribution of AKR1C proteins is likely to be associated with liver tumorigenesis,and the AKR expression status in HuH7 is completely different from other liver cancer cell lines.This study,for the frst time,provided both overall and quantitative information regarding the expression of AKRs at both mRNA and protein levels in hepatic cell lines.Our observations put the previous use of AKRs as a biomarker into question since it is only consistent with our data from HuH7.Furthermore,the data presented herein demonstrated that quantitative evaluation and comparisons within a protein family at both mRNA and protein levels were feasible using current techniques. | Lei Yang Ju Zhang Shenyan Zhang Weiwei Dong Xiaomin Lou Siqi Liu | 2013 | Genomics, Proteomics & Bioinformatics2013，11，4： | 0 |
| 13 | Diagnostic Value of CYFRA21-1, CA19-9 and SCCAg Detection in Esophageal Cancer显示文摘Objectives To investigate the value of serum cytokeratin 19 fragment(CYFRA21-1),carbohydrate anti-gen 19-9(CA19-9)and squamous cell carcinoma antigen(SCCAg)in the diagnosis of esophageal cancer.Methods 100 cases of esophageal cancer(study group)and 50 healthy subjects(control group)were recruited in the study,the serum levels of CYFRA21-1,CA19-9 and SCCAg in these patients were detected.Subgroups analysis was performed in study group by clinical staging,and the diagnostic value of CYFRA21-1,CA19-9 and SCCAg in detecting esophageal cancer was analyzed by receiver operating characteristic curve(ROC).Results The serum levels of CYFRA21-1,CA19-9 and SCCAg in study group were significantly higher than those in control group,and those were significantly lower in patients with stageⅠ-Ⅱdisease than those with stageⅢandⅣdisease,indicating statistically significant difference(P<0.01);the sensitivity of serum CYFRA21-1,CA19-9 and SCCAg in the diagnosis of esophageal cancer was 82.26%,and specificity was 91.33%,with positive predictive value being 86.14%,and negative predictive value being 89.57%,and AUC value was 0.864,the combined detection was superior to each measure utilized alone,the difference was significantly significant(P<0.05).Conclusion The combined detection of serum CYFRA21-1,CA19-9,and SCCAg can significantly improve the diagnostic sensitivity and specificity in detecting the esophageal cancer. | Du Chunran Wang Yanming Hou Shenyan | 2018 | Proceedings of Anticancer Research2018，2，2： | 0 |
| 14 | Research and design on a kind of CASE environment architectural style based on ToolBus显示文摘Because CASE (computer aided software engineering) environment is a kind of complex system software, its software architecture is very important. From the viewpoint of software architecture, this paper first presents TBus architectural style, which is a kind of CASE environment architectural style based on ToolBus, then describes the architectural model and system’s behavior in formal method, researches and analyzes the corresponding tool structural model. Last the paper implements a TBus architectural instance-LambdaBridge, which proves the validity of ToolBus and TBus architectural styles. | GuoBing ShenYan XieJun WangYong XiongGuangze | 2005 | Journal of Systems Engineering and Electronics2005，16，1： | 0 |
| 15 | Structural optimization for multiple structure cases and multiple payload cases with a two-level multipoint approximation method显示文摘This paper is to address structural optimization problems where multiple structure cases or multiple payload cases can be considered simultaneously. Both types of optimization problems involve multiple finite element models at each iteration step, which draws high demands in optimization methods. Considering the common characteristic for these two types of problems, which is that the design domain keeps the same no matter what the structure cases or payload cases are,both problems can be formulated into the unified expressions. A two-level multipoint approximation(TMA) method is firstly improved with the use of analytical sensitivity analysis for structural mass, and then this improved method is utilized to tackle these two types of problems. Based on the commercial finite element software MSC.Patran/Nastran, an optimization system for multiple structure cases and multiple payload cases is developed. Numerical examples are conducted to verify its feasibility and efficiency, and the necessity for the simultaneous optimizations of multiple structure cases and multiple payload cases are illustrated as well. | An Haichao Chen Shenyan Huang Hai | 2016 | Chinese Journal of Aeronautics2016，29，5： | 0 |
| 16 | Research on Collaboration Theory of Distributed Measurement System and Real-Time of Communication Platform显示文摘 | SHENYan | 2005 | Journal of Electronic Science and Technology of China2005，3，1： | 0 |
| 17 | SINTERING BEHAVIOR OF Cu-Al ALLOY POWDER显示文摘SINTERINGBEHAVIOROFCu-AIALLOYPOWDER￥TIANSugui;SHAOHuimeng;ZHOULongjiang;LITiefan;YANGHongcai;HAOShiming(ShenyangPolytechnicUn... | TIAN Sugui SHAO Huimeng ZHOU Longjiang LI Tiefan YANG Hongcai HAO Shiming(Shenyang Polytechnic University, China) (State Key Laboratory of Corrosion and Protection. Institute of Corrosion and Protection of Metals. Chinese Academy of Sciences, Shenyan | 1995 | Acta Metallurgica Sinica(English Letters)1995，8，3： | 0 |
| 18 | FATIGUE DAMAGE AND LIFETIME PREDICTION OF AERONAUTIC WELDED STRUCTURES UNDER HIGH TEMPERATURE显示文摘FATIGUEDAMAGEANDLIFETIMEPREDICTIONOFAERONAUTICWELDEDSTRUCTURESUNDERHIGHTEMPERATUREZuoJianzheng,LouZhiwen,KuangZhenbang(StateK... | Zuo Jianzheng, Lou Zhiwen, Kuang Zhenbang (State Key Laboratory of Mechanical Structural Strength and Vibration, Xi′an Jiaotong University, Xi′an, 710049, China) Yang Shijie (Institute No.606, the Aeroengine General Company of China, Shenyan | 1997 | Chinese Journal of Aeronautics1997，10，3： | 0 |
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