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| 1 | Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A,Z显示文摘H2A.Z 是在所有种类的高度保存的 histone 变体。H2A.Z 的染色质免职被改变复杂 SWR1 和它的哺乳动物的对应物 SRCAP 的酵母染色质明确地催化。然而, H2A.Z 被 non-histone 蛋白质优先地被认出的机制留下逃犯。这里,我们识别了 Anp32e,为 H2A.Z Anp32e 的新奇更高优核质特定的 histone 女伴优先地在 vitro 并且在 vivo 把 dimers 而非 H2A-H2B dimers 与 H2A.Z-H2B 联系并且分裂 non-nucleosomal 总数由 DNA 和 H2A-H2B 形成了。我们与 H2A.Z-H2B 在建筑群决定了 Anp32e 女伴领域(186-232 ) 的水晶结构更暗淡。在这结构,包含 Anp32e 残余 214-224 的区域,在另外的 Anp32 家庭蛋白质不在,明确地与扩大 H2A.Z α 交往; C 螺旋,哪个展览一个意外 conformational 变化。Anp32e 的染色体宽的介绍表明在 Anp32e 和 H2A.Z 房间 overexpressing Anp32e 之间的显著合作占有在 +1 nucleosomes 显示了强壮的全球 H2A.Z 损失,而房间显示的 Anp32e 弄空在 +1 nucleosomes 的中等全球 H2A.Z 增加。这建议 Anp32e 可以帮助解决 non-nucleosomal H2A.Z 总数并且也在 +1 nucleosomes,和后者便于 H2A.Z 的移动可以帮助 RNA 聚合酶 II 通过第一个 nucleosomal 障碍。 | Zhuo Mao Lu Pan Weixiang Wang Jian Sun Shah Shan Qiang Dong Xiaoping Liang Linchang Dai Xiaojun Ding She Chen Zhuqiang Zhang Bing Zhu Zheng Zhou | 2014 | Cell Research2014，24，4： | 6 |
| 2 | Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (H_2O_2) levels in guard cells in Vicia faba显示文摘The role and signaling of sphingosine-1-phosphate (S1P) during darkness-induced stomatal closure were examined in Vicia faba. Darkness substantially raised S1P and hydrogen peroxide (H 2 O 2 ) levels and closed stomata. These darkness effects were significantly suppressed by DL-threo-dihydrosphingosine (DL-threo-DHS) and N,N-dimethylsphingosine (DMS), two inhibitors of long-chain base kinases. Exogenous S1P led to stomatal closure and H 2 O 2 production, and the effects of S1P were largely prevented by the H 2 O 2 modulators ascorbic acid, catalase, and diphenyleneiodonium. These results indicated that S1P mediated darkness-induced stomatal closure by triggering H 2 O 2 production. In addition, DL-threo-DHS and DMS significantly suppressed both darkness-induced cytosolic alkalization in guard cells and stomatal closure. Exogenous S1P caused cytosolic alkalization and stomatal closure, which could be largely abolished by butyric acid. These results demonstrated that S1P syn-thesis was necessary for cytosolic alkalization during stomatal closure caused by darkness. Furthermore, together with the data described above, inhibition of darkness-induced H 2 O 2 production by butyric acid revealed that S1P synthesis-induced cytosolic alkalization was a prerequisite for H 2 O 2 production during stomatal closure caused by darkness, a conclusion supported by the facts that the pH increase caused by exogenous S1P had a shorter lag and peaked faster than H 2 O 2 levels and that butyric acid prevented exogenous S1P-induced H 2 O 2 production. Altogether, our data suggested that darkness induced S1P synthesis, causing cytosolic alkalization and subsequent H 2 O 2 production, finally leading to stomatal closure. | MA YinLi SHE XiaoPing YANG ShuShen | 2012 | Science China(Life Sciences)2012，55，11： | 4 |
| 3 | Reactive oxygen species regulate auxin levels to mediate adventitious root induction in Arabidopsis hypocotyl cuttings显示文摘Adventitious root(AR)formation from leafy stem cuttings is critical for breeding of many forest and horticultural species.In addition to the plant hormone auxin,wound-induced signaling caused by the cutting excision is also essential for AR initiation.Here we found that reactive oxygen species(ROS)are rapidly generated at the excision site as a wound-induced signal and propagated throughout the hypocotyl cut-ting after excision of the Arabidopsis(Arabidopsis thaliana)primary root.ROS propagation was not ob-served in the presence of an NADPH oxidase inhibitor(diphenylene iodonium chloride)or in a knockout mu-tant of the NADPH oxidase gene respiratory burst oxi-dase homolog protein D(RBOHD).Respiratory burst oxidase homolog protein D was specifically upregulatedin hypocotyl cuttings at 0.5 h post excision(hpe).To-gether,these data suggest that RBOHD mediates ROS propagation in hypocotyl cuttings.We also found that auxin levels increased significantly in the shoot apex at 5 hpe and at the base of the cutting at 6 hpe;these effects were blocked by treatment with ROS scav-engers.Consistent with this,transcript levels of auxin biosynthesis and polar-transport genes generally in-creased between 1 to 6 hpe.Collectively,our results suggest that wound-induced ROS participate in AR in-duction through regulation of auxin biosynthesis and transport. | Aixia Huang Yongshun Wang Yangyang Liu Guodong Wang Xiaoping She | 2020 | Journal of Integrative Plant Biology2020，62，7： | 3 |
| 4 | Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains显示文摘The worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 4.5 million deaths.Although coronaviruses have a proofreading mechanism to maintain the stability of their long genomic RNAs,mutations emerge continuously,and new variants conferring advantages rapidly become the dominant lineages[1].Strategies to fight the COVID-19 pandemic using either vaccines or nonpharmaceutical interventions have specifically been threatened by the emergence of SARS-CoV-2 variants of concern(VOCs)[2]. | Ting Pan Zhongwei Hu Fengyu Hu Yiwen Zhang Bingfeng Liu Changwen Ke Qiumin She Xin He Xiaoping Tang Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 5 | Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth显示文摘 | Hailin Tang Xiaoping Liu Zeyou Wang Xiaoling She Xi Zeng Min Deng Qianjin Liao Xiaofang Guo Rong Wang Xiaoling Li Fang Zeng Minghua Wu Guiyuan Li | 2011 | Brain Research2011，，： | 1 |
| 6 | Blind source separation based on high-resolution time–frequency distributions显示文摘 | Jing Guo Xiaoping Zeng Zhishun She | 2011 | Computers and Electrical Engineering2011，，1： | 1 |
| 7 | Effects of oligochitosans on tobacco cells and role of endogenous nitric oxide burst in the resistance of tobacco to Tobacco mosaic virus显示文摘 | Zhao Xiaoming She Xiaoping Yu Weiting | 2007 | Journal of Plant Pathology2007，89，1： | 1 |
| 8 | Role and relationship of nitric oxide and hydrogen peroxide in light/dark regulated-stomatal movement in Vicia faba 显示文摘 | She Xiaoping Song Xigui He Junmin | 2004 | Acta Botanica Sinica2004，46，11： | 1 |
| 9 | Pharmacological evidence indicates that MAPKK/CDPK modulate NO level in dark-induced stomatal closure 显示文摘 | She Xiaoping Song Xigui | 2008 | Australia Journal of Botany2008，56，： | 1 |
| 10 | MAPK kinase and CDP kinase modulate hydrogen peroxide levels during dark-induced stomatal closure in guard cells of Vieia faba显示文摘 | Song Xigui She Xiaoping Guo Linying | 2008 | Botanical Studies2008，49，： | 1 |
| 11 | Role and rela- tionship of nitric oxide and hydrogen peroxide in light / dark regulated stomatal movement in Vicia faba显示文摘 | She Xiaoping Song Xigui He Junmin | 2004 | Acta Botanica Sinica2004，46，： | 1 |
| 12 | The dynamic distribution of NO and NADPH-diaphorase activity during IBA-induced adventitious root formation 显示文摘 | Huang Aixia She Xiaoping Huang Chen | 2007 | Physiologia Plantarum2007，130，： | 1 |
| 13 | Cytokinin- and auxin-in- duced stomatal opening is related to the change of nitric oxide levels in guard cells in broad bean显示文摘 | She Xiaoping Song Xigu | 2006 | Physiologia Plantarum2006，128，： | 1 |
| 14 | Role and relationship of nitric oxide and hydrogen peroxide in light/dark-regulated stomatal movement in Vicia faba 显示文摘 | SHE Xiaoping SONG Xigui HE Junmin | 2004 | Acta Botanica Sinica2004，46，11： | 1 |
| 15 | Role and relationship of nitric oxide and hydrogen peroxide in light/dark-regulated stomatal movement in Vicia faba 显示文摘 | SHE Xiaoping SONG Xigui HE Junmin | 2004 | Acta Botanica Sinica2004，，： | 1 |
| 16 | Induction of antiviral resistance and stimulary effect by oligochitosan in tobacco显示文摘 | Xiaoming Zhao Xiaoping She Yuguang Du | 2007 | Pesticide Biochemistry and Physiology2007，87，1： | 1 |
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