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| 1 | Idiopathic fistula-in-ano显示文摘Fistula-in-ano is the most common form of perineal sepsis.Typically,a fistula includes an internal opening,a track,and an external opening.The external opening might acutely appear following infection and/or an abscess,or more insiduously in a chronic manner.Management includes control of infection,assessment of the fistulous track in relation to the anal sphincter muscle,and finally,definitive treatment of the fistula.Fistulotomy was the most commonly used mode of management,but concerns about post-fistulotomy incontinence prompted the use of sphincter preserving techniques such as advancement flaps,fibrin glue,collagen fistula plug,ligation of the intersphincteric fistula track,and stem cells.Many descriptive and comparative studies have evaluated these different techniques with variable outcomes.The lack of consistent results,level I evidence,or long-term follow-up,as well as the heterogeneity of fistula pathology has prevented a definitive treatment algorithm.This article will review the most commonly available modalities and techniques for managing idiopathic fistula-in-ano. | Sherief Shawki Steven D Wexner | 2011 | World Journal of Gastroenterology2011，17，28： | 7 |
| 2 | Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection显示文摘AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), Pohl score, G teborg University Cirrhosis Index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: < 0.01, < 0.05, < 0.001 and < 0.001, respectively. Among the studied parameters, AAR and GUCI gave the highest diagnostic accuracy (80.5%) with cutoff values of 1.2 and 1.5, respectively. APRI, API and GUCI were significantly correlated with the stage of fibrosis (P < 0.001) and the grade of activity (P < 0.001, < 0.001 and < 0.005, respectively), while CDS only correlated significantly with the stage of fibrosis (P < 0.001) and not with the degree of activity (P > 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and Pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: < 0.001, < 0.05, < 0.001, < 0.001 and < 0.005, respectively; CDS did not demonstrate significant correlation (P > 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and Pohl score measurements may decrease the need for liver biopsies in diagnosing cirrhosis, especially in Egypt, where resources are limited. | Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 3 | Ureteroscopic management of lower ureteric calculi: a 15‐year single‐centre experience显示文摘 | Osama M.Elashry Abdelnaser K.Elgamasy Magdy A.Sabaa MohamedAbo‐Elenien Mohamed AdelOmar Hassan H.Eltatawy Shawky A.El‐Abd | 2008 | BJU International2008，，8： | 5 |
| 4 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 5 | Spatial analysis of public health facilities in Riyadh Governorate,Saudi Arabia:a GIS-based study to assess geographic variations of service provision and accessibility显示文摘Much attention has been given to address public health policy in Saudi Arabia,particularly for the management,quality,and coverage issues.However,assessment of spatial patterns,distribution,and provision of public health services has been neglected.This paper analyzes the availability and accessibility of public health facilities across Riyadh Governorate,Saudi Arabia at the subnational level.Spatial and attribute data of public health facilities potentially have been analyzed using GIS to produce accurate measure of accessibility.The spatial pattern of service distribution was examined using average nearest neighbor.Distances from demand points(populations)to providers(facilities)were calculated for each district using near analysis.In addition,the ratios of public health facility to population were calculated to identify underserved and overserved areas.The findings clearly indicate that the spatial pattern of the distribution of public health facilities was significantly clustered(p value<0.001)with Z-score of–10.9.Several districts within the central parts of the governorate were identified as having a higher density of facilities,while most of districts that are located in the marginal parts exhibit very low density of health facilities.Overall,there was a considerable variation in the average distance from district centroids to health facilities.Substantially,less than half of the population(45.4%)living in 61 districts has access to public health facility within less than 1-km distance.In contrast,the greatest increase in distances was observed for 6%of population living in 38 districts.People that live in such districts need to travel long distances for public health care.The output of this analysis can assist policy-makers and authorities of Riyadh Governorate in planning public health delivery. | Shawky MANSOUR | 2016 | Geo-Spatial Information Science2016，19，1： | 4 |
| 6 | Gossypol inhibits proliferation of endometrioma cells in culture显示文摘瞄准:为了在子宫内膜瘤评估 anti-proliferative 活动和棉子酚的 mitochondrial 毒性,房间在短期的文化维持了。方法:三 endometriomacell 从病人衬里的(A) 与 25 或 50 nmol/L 棉子酚被对待多达 12 天。细胞生长上的棉子酚的效果被记录。(B) A 磷光氧分析器被用来从病人在六根子宫内膜瘤房间线的 mitochondrial 耗氧量上决定棉子酚的效果。(C) 在从病人的三根子宫内膜瘤房间线的细胞的棉子酚累积被高压的液相色谱法测量。结果:endometriomacells 的增长被 25 和 50 nmol/L 棉子酚禁止。子宫内膜瘤房间的呼吸被 10 μ m ol/L 棉子酚禁止。细胞的棉子酚在与 10 和 0.3 μ m ol/L 棉子酚为 24 h 被对待的子宫内膜瘤房间线被检测。结论:棉子酚在有教养的子宫内膜瘤房间上调用有势力毒性。 | Shawky Z. A. Badawy Abdul-Kader Souid Violeta Cuenca Nicholas Montalto Frances Shue | 2007 | Asian Journal of Andrology2007，9，3： | 3 |
| 7 | Expression levels of pro-inflammatory interleukin-8 and certain antimicrobial peptides in concurrent with bacterial conjunctivitis显示文摘AIM:To detect the quantitative expression levels of the pro-inflammatory interleukin-8(IL8),antimicrobial peptides human beta defense-2(HBD2),and human beta defense-3(HBD3)genes in bacterial conjunctivitis.METHODS:The human conjunctival epithelial cells were obtained using the impression cytology technique from healthy controls and patients.The genes expression levels were determined utilizing a reverse transcription quantitative polymerase chain reaction(RT-q PCR).The contribution of causative agent type,the number of isolates and severity of clinical features,in the increase of genes expression was also determined.RESULTS:The RT-q PCR showed that IL8,HBD2,and HBD3 expression increased in bacterial conjunctivitis as compared to healthy control(P<0.001).In gram-negative bacterial conjunctivitis,HBD2 was highly up-regulated(P<0.001)compared to other types of bacterial conjunctivitis.In mixed bacterial conjunctivitis,a direct correlation between HBD2 up-regulation and HBD3 up-regulation was observed(P<0.05).The severity of clinical features was related to the up-regulation of IL8 and HBD2(P<0.05).CONCLUSION:IL8,HBD2,and HBD3 are immuneeffectors in infectious conjunctivitis.HBD2 is active during different bacterial conjunctivitis but is more released with gram-negative bacteria compared to gram-positive bacteria.HBD3 is an obvious defender in different bacterial conjunctivitis. | Alaa El-Dien Shawky Hosny Zeinab El-Demerdash El-Bazza Mohammed Abdelhalim Ramadan Maha Ahmed Shafik Mahmoud Ahmed Shafeek Rania Abdelmonem Khattab | 2021 | International Journal of Ophthalmology(English edition)2021，14，5： | 2 |
| 8 | Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results 显示文摘 | Khedr EM Rothwell JC Shawky OA | 2007 | Mov Disord2007，22，7： | 1 |
| 9 | Egyptian Jour- nal of Medical Human Genetics显示文摘 | Shawky RM E1-Sedfy HH E1-Sobky E | 2013 | Human Genetics2013，14，2： | 1 |
| 10 | The collapse mechanism of a subway station during the Great Hanshin Earthquake显示文摘 | AN X H SHAWKY A A MAEKAWA K | 1997 | Cement and Concrete Composites1997，19，： | 1 |
| 11 | Comparison between antigen capture ELISA and conventional methods used for titration of infectious bursal disease virus显示文摘 | HASSAN M K SAIF Y M SHAWKY S | 1996 | Avian Dis1996，40，3： | 1 |
| 12 | Liquidity and stock returns in emerging equity markets显示文摘 | JUN S G MARATHE A SHAWKY H A | | 0，，01： | 1 |
| 13 | Pathogenicity of a low-virulence duck virus enteritis isolate with apparent immunosuppressive ability显示文摘 | SHAWKY S SANDHU T SHIVAPRASAD H L | 2000 | Avian Dis2000，44，3： | 1 |
| 14 | Distributions pattern of organotin compounds at different trophiclevers of aquatic ecosystems 显示文摘 | SHAWKY S EMONS H | 1998 | Chemosphere1998，36，3： | 1 |
| 15 | Target cells for duck enteritis virus in lymphoid organs显示文摘 | Shawky S | 2000 | Avian Pathol2000，29，： | 1 |
| 16 | Black nickel coating for solar collec- tors 显示文摘 | Shawki S Mikhail S | 2000 | Mater Manufact Proc2000，15，5： | 1 |
| 17 | Eldin Aalpha-fetoprotein in screening for congenial hypothyroidism显示文摘 | Shawky RM Abdel FS | 2001 | East Mediter Health J2001，7，12： | 1 |
| 18 | The collapse mechanism of a subway station during the Great Hanshin Earthquake 显示文摘 | An X Shawky A A Maekawa K | 1997 | Cement and Concrete Composites1997，19，3： | 1 |
| 19 | Synthesis and characterization of a carbon nanotube/polymer nanoeomposite membrane for water treatment 显示文摘 | Shawky H A | 2011 | Desalination2011，272，123： | 1 |
| 20 | Effects of operating conditions and supply hole diameter on the performance of a rectangular aerostatic bearing显示文摘 | Kassab S Z Noureldeen E M Shawky M A | | 0，，07： | 1 |
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