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| 1 | Gut microbiota mediated molecular events and therapy in liver diseases显示文摘Gut microbiota is a community of microorganisms that reside in the gastrointestinaltract. An increasing number of studies has demonstrated that the gutliveraxis plays a critical role in liver homeostasis. Dysbiosis of gut microbiota cancause liver diseases, including nonalcoholic fatty liver disease and alcoholic liverdisease. Preclinical and clinical investigations have substantiated that themetabolites and other molecules derived from gut microbiota and diet interactionfunction as mediators to cause liver fibrosis, cirrhosis, and final cancer. This effecthas been demonstrated to be associated with dysregulation of intrahepaticimmunity and liver metabolism. Targeting these findings have led to thedevelopment of novel preventive and therapeutic strategies. Here, we review thecellular and molecular mechanisms underlying gut microbiota-mediated impacton liver disease. We also summarize the advancement of gut microbiota-basedtherapeutic strategies in the control of liver diseases. | Xiaoqiang Qi Ming Yang Joseph Stenberg Rahul Dey Leslie Fogwe Muhammad Shawkat Alam Eric TKimchi Kevin F Staveley-O'Carroll Guangfu Li | 2020 | World Journal of Gastroenterology2020，26，48： | 5 |
| 2 | Nystagmus in infan-cy显示文摘 | Casteels I Harris CM Shawkat F Taylor D | 1992 | BrJ Ophthalmol1992，76，7： | 1 |
| 3 | Allelic variation of the FRMD7 gene in congenital idiopathic nystagmus显示文摘 | Self J Shawkat F Malpas C T | 2007 | Arch Ophthalmol2007，125，9： | 1 |
| 4 | A study of the effects of contrast change on pattern VEPs, and the transition between onset, reversal and offset modes of stimulation显示文摘 | Shawkat F S Kriss A | 2000 | Doe Ophthalmol2000，101，1： | 1 |
| 5 | A study of the effects of contrast change on pattern VEPs, and the transition between onset, reversal and offset modes of stimulation显示文摘 | Shawkat F S Kriss A | 2000 | Doe Ophthalmol2000，101，1： | 1 |
| 6 | Nystagmus in infancy显示文摘 | Casteels I Harris CM Shawkat F | 1992 | Br J Ophthalmol1992，76，7： | 1 |
| 7 | Nystagmus in infancy显示文摘 | Casteels I Harris C M Shawkat F | 1992 | Br J Ophthalmol1992，76，7： | 1 |
| 8 | Rationales and uncertainties for aspirin use in COVID-19:a narrative review显示文摘Objectives To review the pathophysiology of COVID-19 disease,potential aspirin targets on this pathogenesis and the potential role of aspirin in patients with COVID-19.Design Narrative review.Setting The online databases PubMed,OVID Medline and Cochrane Library were searched using relevant headlines from 1 January 2016 to 1 January 2021.International guidelines from relevant societies,journals and forums were also assessed for relevance.Participants Not applicable.Results A review of the selected literature revealed that clinical deterioration in COVID-19 is attributed to the interplay between endothelial dysfunction,coagulopathy and dysregulated inflammation.Aspirin has anti-inflammatory effects,antiplatelet aggregation,anticoagulant properties as well as pleiotropic effects on endothelial function.During the COVID-19 pandemic,low-dose aspirin is used effectively in secondary prevention of atherosclerotic cardiovascular disease,prevention of venous thromboembolism after total hip or knee replacement,prevention of pre-eclampsia and postdischarge treatment for multisystem inflammatory syndrome in children.Prehospital low-dose aspirin therapy may reduce the risk of intensive care unit admission and mechanical ventilation in hospitalised patients with COVID-19,whereas aspirin association with mortality is still debatable.Conclusion The authors recommend a low-dose aspirin regimen for primary prevention of arterial thromboembolism in patients aged 40-70 years who are at high atherosclerotic cardiovascular disease risk,or an intermediate risk with a risk-enhancer and have a low risk of bleeding.Aspirin’s protective roles in COVID-19 associated with acute lung injury,vascular thrombosis without previous cardiovascular disease and mortality need further randomised controlled trials to establish causal conclusions. | Hazem A Sayed Ahmed Eric Merrell Mansoura Ismail Anwar I Joudeh Jeffrey B Riley Ahmed Shawkat Hanan Habeb Edward Darling Reda A Goweda Mohamed H Shehata Hossam Amin Gary F Nieman Hani Aiash | 2021 | Family Medicine and Community Health2021，9，2： | 0 |
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