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| 1 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 2 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 3 | History of materialsused for recording static and dynamic occlusal contact marks : aliterature review 显示文摘 | Sharma A Rahul GR Poduval ST | 2013 | J Clin Exp Dent2013，5，1： | 1 |
| 4 | Molecular cloning and sequence analysis of the penton base genes of type Ⅱ avian adenoviruses显示文摘 | St Cyr S Sharma J M | 1995 | Virus Res1995，39，23： | 1 |
| 5 | Novel taxol formulation : preparation and characterization of taxol-containing liposomes显示文摘 | SHARMA A ST RAUBINGER RM | 1994 | Pharm Res1994，11，6： | 1 |
| 6 | Using admission characteristics to predict short-term mortality from myocardial infarcion in elderly patients: results from the Cooperative Cardiovascular Project 显示文摘 | Normand ST Glickman ME Sharma RG | 1996 | JAMA1996，275，17： | 1 |
| 7 | Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizes 显示文摘 | Sharma ST Nestler JE | 2006 | Best Praet Res Clin Endocrinol Metab2006，20，2： | 1 |
| 8 | Prevention of diabetes and cardiovascular disease in women with PCOS:Treatment with insulin sensitizers显示文摘 | Sharma ST Nestler JE | 2006 | Best Pract Res CI En2006，20，2： | 1 |
| 9 | Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACT H seeretion 显示文摘 | Sharma ST Nieman LK | 2012 | Eur J Endocrinol2012，166，3： | 1 |
| 10 | Uneasy breather:the implications of dust mite allergens显示文摘 | Sharma S Lackie PM Holgate ST | 2003 | Clin Exp Allergy2003，33，2： | 1 |
| 11 | Antimicrobial susceptibility pattern and prevalence of extended spectrum beta-lactamase (ESBLs ) producing strains of Klebsiella pneumoniae from a major hospital in New Delhi 显示文摘 | Grover SS Sharma M Pasha ST | 2004 | J Commun Dis2004，36，1： | 1 |
| 12 | An L-type calcium channel blocker, ni- modipine influences trauma induced spinal cord conduction and axonal injury in the rat显示文摘 | Winkler T Sharma HS St?lberg E | 2003 | Acta Neurochir Suppl2003，86，： | 1 |
| 13 | Prolonged remission after long-term treatment with steroidogenesis inhibitors in Cushing's syndrome caused by ectopic ACTH secretion显示文摘 | Sharma ST Nieman LK | 2012 | Eur J Endocrinol2012，166，3： | 1 |
| 14 | Cushing's syndrome: all variants, detection, and treatment显示文摘 | Sharma ST Nieman LK | 2011 | Endocrinol Metab Clin North Am2011，40，2： | 1 |
| 15 | First-trimester screening for aneuploidy with fetal nuchal translucency in a United States population显示文摘 | Chasen ST Sharma G Kalish RB | 2003 | Ultrasound Obstet Gynecol2003，22，2： | 1 |
| 16 | First-trimester screening for aneuploidy with fetal nuchal translucency in United States population显示文摘 | Chasen ST Sharma G Kalish RB | 2003 | Ultrasound Obstet Gynecol2003，22，： | 1 |
| 17 | Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fiber pathology 显示文摘 | Britland ST Young RJ Sharma AK | 1992 | Pain1992，48，3： | 1 |
| 18 | Relationship of endoneurial capillary abnormalities to type and severity of diabetic neuropathy显示文摘 | Britland ST Young RJ Sharma AK | 1990 | Diabetes1990，39，： | 1 |
| 19 | First-trimester screeningfor aneuploidy with fetal nuchal translucency in a United Statespopulation显示文摘 | Chasen ST Sharma G Kalish RB | 2003 | Ultrasound Obstet Gynecol2003，22，2： | 1 |
| 20 | Changes in glucose tolerance with metformin treatment in polycystic ovary syndrome:a retrospective analysis显示文摘 | Sharma ST Wickham EP 3rd Nestler JE | 2007 | Endocr Pract2007，13，4： | 1 |
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