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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | Use of anti-craving agents in soldiers with alcohol dependence syndrome显示文摘 | Narayana PL Gupta AK Sharma PK | 2008 | Med J Armed Forces India2008，64，4： | 1 |
| 3 | Modulation of the cardioprotective effect of ischemic preconditioning in hyperlipidaemic rat heart 显示文摘 | Yadav HN Singh M Sharma PL | 2010 | Eur J Pharmacol2010，643，1： | 1 |
| 4 | Involvement of vascular endothe- lial nitric oxide synthase in development of experimental diabetic nephropathy in rats显示文摘 | Arya A Yadav HN Sharma PL | 2011 | Mol Cell Biochem2011，354，12： | 1 |
| 5 | MRI sign of nodular fasci- itis:a case report显示文摘 | Sharma AK Scott G Westession PL | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，105，： | 1 |
| 6 | In vivo proton spectroscopy of giant cell Tumor of the bone 显示文摘 | Sah PL Sharma R Kandpal H | 2008 | Am J Roentgenol2008，190，2： | 1 |
| 7 | Beneficial effects of angiotensin(1-7)in diabetic rats with cardiomyopathy显示文摘 | Singh K Singh T Sharma PL | | 0，，03： | 1 |
| 8 | Involvement of GSK-313 in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic rat heart显示文摘 | Yadav HN Singh M Sharma PL | 2010 | Mol Cell Biochem2010，343，12： | 1 |
| 9 | Possible mechanism of protective effect of thalidomide in STZ-induced-neuropathic pain behavior in rats显示文摘 | Taliyan R Sharma PL | 2012 | Inflammop harmacology2012，20，2： | 1 |
| 10 | Fluorescent dye terminator sequencing methods for quantitative determination of replication fitness of human immunodeficiency virus type 1 containing the codon 74 and 184 mutations in reverse transcriptase显示文摘 | Nurpeisov V Hurwitz SJ Sharma PL | 2003 | J Clin Microbiol2003，41，7： | 1 |
| 11 | Determination of reansition metals in wine by ICP,DPASV-DPCSV and ZGFAAS coupled with UV photolysis显示文摘 | Buldini PL Cavalli S Sharma JL | 1999 | J Agricultural and Food Chemistry1999，47，： | 1 |
| 12 | Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: critical role of brain hyperthermia显示文摘 | Kiyatkin EA Brown PL Sharma HS | 2007 | The European Journal of Neuroscience2007，26，5： | 1 |
| 13 | MRI sign of nodular fasciitis: a case report显示文摘 | Sharma AK Scott G Westesson PL | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，105，5： | 1 |
| 14 | Possible attenuation of ni- tric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat显示文摘 | Goyal R Sharma PL Singh M | 2011 | J Nat Med2011，65，34： | 1 |
| 15 | Anti-inflamm&tory &nd &ntihyper&lgesic effects of the combin&tion of ibuprofen &rid hemin in &djuvant-induced &rthritis in the Wistar rat显示文摘 | Kaur $ Bijjem KR Sharma PL | | Inflammoph&rmaco]ogy0，19，5： | 1 |
| 16 | Involvement of vas cular endothelial nitric oxide synthase in development of experimental diabetic nephropathy in rats显示文摘 | Atul A Harlokesh Ny Sharma PL | 2011 | Mol Cell Bioch2011，354，12： | 1 |
| 17 | Topotecan inhibits human immunodeficiency virus type 1 infection through a topoisomerase-independent mechanism in a cell line with altered topoisomerase I显示文摘 | Zhang JL Sharma PL Li CJ | 1997 | Antimicrob Agents Chemother1997，41，5： | 1 |
| 18 | Ameliorative effect of daidzein: a caveolin - 1 inhibitor in vascular endothelium dysfunction induced by o- variectomy显示文摘 | Sharma S Singh M Sharma PL | 2012 | Indian J Exp Biol2012，50，1： | 1 |
| 19 | Preoperative evaluation of spinal vascular malformation by MR angiography: How reliable is the technique Case report and review of literature 显示文摘 | Sharma AK Westesson PL | 2008 | Clin Neurol Neurosurg2008，110，： | 1 |
| 20 | Protective effect and potential mechanism of Ginkgo biloba extract EGb 761 on STZ- induced neuropathic pain in rats显示文摘 | Taliyan R Sharma PL | 2012 | Phytother Res2012，26，12： | 1 |
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