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1篇 您的检索式：作者名="Shani Dror"

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		题名	作者	年代	出处	被引量
	1	Parkin Somatic Mutations Link Melanoma and Parkinson's Disease显示文摘Epidemiological studies suggest a direct link between melanoma and Parkinson's disease(PD); however, the underlying molecular basis is unknown. Since mutations in Parkin are the major driver of early-onset PD and Parkin was recently reported to play a role in cancer development, we hypothesized that Parkin links melanoma and PD. By analyzing whole exome/genome sequencing of Parkin from 246 melanoma patients, we identified five non-synonymous mutations, three synonymous mutations, and one splice region variant in Parkin in3.6% of the samples. In vitro analysis showed that wild-type Parkin plays a tumor suppressive role in melanoma development resulting in cell-cycle arrest, reduction of metabolic activity, and apoptosis. Using a mass spectrometry-based analysis, we identified potential Parkin substrates in melanoma and generated a functional protein association network. The activity of mutated Parkin was assessed by protein structure modeling and examination of Parkin E3 ligase activity. The Parkin-E28 K mutation impairs Parkin ubiquitination activity and abolishes its tumor suppressive effect. Taken together, our analysis of genomic sequence and in vitro data indicate that Parkin is a potential link between melanoma and Parkinson's disease. Our findings suggest new approaches for early diagnosis and treatment against both diseases.	Lotan Levin Shani Srour Jared Gartner Oxana Kapitansky Nouar Qutob Shani Dror Tamar Golan Roy Dayan Ronen Brener Tamar Ziv Mehdi Khaled Ora Schueler-Furman Yardena Samuels Carmit Levy	2016	Journal of Genetics and Genomics2016，43，6：	0

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