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| 1 | Aqueous extracts of microalgae exhibit antioxidant and anticancer activities显示文摘Objective:To investigate the antioxidant and anticancer activities of aqueous extracts of nine microalgal species.Methods:Variable percentages of major secondary metabolites(total phenolic content,terpenoids and alkaloids) as well as phycobiliprotein pigments(phycocyanin, allophycocyanin and phycoerythrin) in the aqueous algal extracts were recorded.Antioxidant activity of the algal extracts was performed using 2,2 diphenyl-1-picrylhydrazyl(DPPH) test and 2,2'azino-bis(ethylbenzthiazoline-6-sulfonic acid(ABTS.) radical cation assay.Anticancer efficiency of the algal water extracts was investigated against Ehrlich Ascites Carcinoma cell(EACC) and Human hepatocellular cancer cell line(HepG2).Results:Antioxidant activity of the algal extracts was performed using DPPH test and ABTS.^+ radical cation assays which revealed 30.1-72.4%and 32.0-75.9%respectively.Anticancer efficiency of the algal water extracts was investigated against Ehdich Ascites Carcinoma Cell(EACC) and Human Hepatocellular cancer cell line(HepG2) with an activity ranged 87.25%and 89.4%respectively.Culturing the promising cyanobacteria species;Nostoc muscorum and Oscillatoria sp.under nitrogen stress conditions(increasing and decreasing nitrate content of the normal BG11 medium,1.5 g/L),increased nitrate concentration(3,6 and 9 g/L) led to a remarkable increase in phycobilin pigments followed by an increase in both antioxidant and anticancer activities in both cyanobacterial species.While the decreased nitrate concentration(0.75,0.37 and 0.0 g/L) induced an obvious decrease in phycobilin pigments with complete absence of allophycocyanin in case of Oscillatoria sp.Conclusions:Nitrogen starvation(0.00 g/L nitrate) induced an increase and comparable antioxidant and anticancer activities to those cultured in the highest nitrate content. | Sanaa MM Shanab Soha SM Mostafa Emad A Shalaby Ghada I Mahmoud | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 6 |
| 2 | Metabolic stress response implicated in diabetic retinopathy:the role of calpain,and the therapeutic impact of calpain inhibitor显示文摘 | Shanab AY Nakazawa T Ryu M | 2012 | Neurobiol Dis2012，48，： | 1 |
| 3 | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis:asso- eiation with toll-like receptor 4 expression and plasma levels of interleukin 8显示文摘 | Shanab AA Scully P Crosbie O | 2011 | Dig Dis Sci2011，56，5： | 1 |
| 4 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction:evidence for pkcactivation and oxidative stress-activated signaling pathways 显示文摘 | RAGHEB R SHANAB G MEDHAT A M | 2009 | Biochem Bioph Res Co2009，389，2： | 1 |
| 5 | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with Toll-like receptor 4 expression and plasma levels of interleukin 8 显示文摘 | Shanab AA Scully P Crosbie O Buckley M O'Mahony L Shanahan F Gazareen S Murphy E Quigley EM | 2011 | Dig Dis Sci2011，56，5： | 1 |
| 6 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress- activated signaling pathways 显示文摘 | Ragheb R Shanab GM Medhat AM | 2009 | Biochem Biophys Res Commun2009，389，2： | 1 |
| 7 | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll- like receptor 4 expression and plasma levels of interleukin 8 显示文摘 | Ahmed Abu Shanab Paul Scully Orla Crosbie | 2010 | Dig Dis Sci2010，3，： | 1 |
| 8 | The role of the gut microbiota in nonalcoholic fatty liver disease显示文摘 | Abu - Shanab A Quigley EM | 2010 | Nat Rev Gastroenterol Hepa- tol2010，7，12： | 1 |
| 9 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction:evidence for PKC activation and oxidative stress activated signaling pathways显示文摘 | Ragheb R Shanab GM | | 0，，02： | 1 |
| 10 | Allelopathic effects of water hyacinth (Eichhornia crassipes)显示文摘 | Shanab S M M Shalaby E A Lightfoot D A | 2010 | PLoS One2010，5，13： | 1 |
| 11 | New Chemometrics Mode Based on Adjacent Data Points' Differences for the Simultaneous Determination of Clopidogrel, Atorvastatin, and Aspirin in their Combined Ternary Drug Formulation 显示文摘 | Nejem RM Issa MM Shanab AA | 2014 | Sci Pharm2014，82，3： | 1 |
| 12 | Nerve growth factor in diabetic retinopathy: beyond neurons 显示文摘 | Mysona BA Shanab AY Elshaer SL | 2014 | Expert Rev Ophthalmol2014，9，2： | 1 |
| 13 | Metabolic stress response implicated in diabetic retinopathy: the role of calpain, and the thera- peutic impact of calpain inhibitor显示文摘 | Shanab A Y Nakazawa T Ryu M | 2012 | Neurobiol Dis2012，48，3： | 1 |
| 14 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction:Evidence for PKC activation and oxidative stress-activated signaling pathways显示文摘 | RAGHEB R SHANAB GM MEDHAT AM | 2009 | Biochem Biophys Res Commu2009，389，2： | 1 |
| 15 | Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction:evidence for PKC activation and oxidative stress-activated signaling pathways显示文摘 | RAGHEB R SHANAB G M MEDHAT A M | | 0，，02： | 1 |
| 16 | Bioremoval capacity of three heavy metals by some microalgae species (Egyptian isolates) 显示文摘 | Shanab S Essa A Shalaby E | 2012 | Plant Signal Behavior2012，7，3： | 1 |
| 17 | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8显示文摘 | Shanab AA Scully P Crosbie O | 2011 | Dig Dis Sci2011，56，5： | 1 |
| 18 | Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8显示文摘 | Shanab A A Scully P Crosbie O | 2011 | Dig Dis Sci2011，56，5： | 1 |
| 19 | Small intestinal bacterial over- growth in nonalcoholic steatohepatitis:association with toll-like receptor 4 expression and plasma levels of interleukin 8 显示文摘 | Shanab AA Scully P Crosbie O | 2011 | Dig Dis Sci2011，56，5： | 1 |
| 20 | Enteromorpha compressa Exhibits Potent Antioxidant Activity显示文摘 | Sanaa M. M. Shanab Emad A. Shalaby Eman A. El-Fayoumy Michael D. Coleman | 2011 | Journal of Biomedicine and Biotechnology2011，，： | 1 |
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