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| 1 | Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects显示文摘β-Catenin plays a critical role in cartilage formation and development. To further understand the role of β-catenin in osteoarthritis(OA) development in temporomandibular joint(TMJ), we have generated β-catenin conditional activation mice(β-cat(ex3)^(Agc1CreER))by breeding Agc1-CreER mice with β-catenin^(flox(ex3)/+)mice. Results of histologic analysis showed the progressive TMJ defects in 3-and 6-month-old β-cat(ex3)^(Agc1CreER)mice(tamoxifen induction was performed at 2 weeks of age), including decreased chondrocyte numbers in the superficial layer associated with less Alcian blue staining, increased numbers of hypertrophic chondrocytes in deep layers, and rough articular surface. Compared to the TMJ phenotype of β-cat(ex3)^(Col2CreER)mice, β-cat(ex3)^(Agc1CreER)mice showed much severe morphological defects in the superficial layer of TMJ. This may reflect that Agc1-CreER mice could efficiently target cells in the superficial layer of TMJ. Results of immunostaining showed significantly increased expression of MMP13, Col-X, Adamts4,and Adamts5 in TMJ of β-cat(ex3)^(Agc1CreER)mice. Results of proliferating cell nuclear antigen(PCNA), Ki67, and terminal deoxinucleotidyl transferase-mediated d UTP-fluorescein nick end labeling(TUNEL) staining further demonstrated that cell proliferation was decreased and cell apoptosis was increased in condylar cartilage of β-cat(ex3)^(Agc1CreER)mice. Our findings indicate that abnormal upregulation of β-catenin in TMJ leads to defects assembling to OA-like phenotype, further demonstrating that β-catenin plays a critical role in TMJ pathogenesis. | Tianqian Hui Yachuan Zhou Tingyu Wang Jun Li Shanxing Zhang Lifan Liao Jianhong Gu Ling Ye Lan Zhao Di Chen | 2018 | International Journal of Oral Science2018，10，2： | 6 |
| 2 | A new method for early detection of myocardial ischemia:cardiodynamicsgram(CDG)显示文摘Early detection of myocardial ischemia via electrocardiographic methods is important and challenging. In the study, based on the standard 12-lead electrocardiography(ECG), a new method called cardiodynamicsgram(CDG) is proposed for early detection of myocardial ischemia. Using a recently proposed deterministic learning algorithm, the cardiodynamics information is extracted from the ST-T segments of standard 12-lead ECG. The CDG is generated by plotting the three-dimensional cardiodynamics information. By analyzing CDG morphology, it is found that significant correlations exist between CDG and ischemia. By evaluating ischemia patients and healthy controls from the Physikalisch-Technische Bundesanstalt(PTB) database and the General Hospital of Guangzhou Military Command, the CDG method achieves a mean sensitivity of 90.3% and a mean specificity of 87.8%, which are higher than those of both the standard 12-lead ECG and the exercise ECG. As it is noninvasive, convenient, and inexpensive, it is hopeful that CDG may become a cost-effective screening method for early detection of ischemic heart diseases. | Cong WANG Xunde DONG Shanxing OU Wei WANG Junmin HU Feifei YANG | 2016 | Science China(Information Sciences)2016，59，1： | 5 |
| 3 | Electrocardiogram(ECG) pattern modeling and recognition via deterministic learning显示文摘A method for electrocardiogram(ECG) pattern modeling and recognition via deterministic learning theory is presented in this paper. Instead of recognizing ECG signals beat-to-beat, each ECG signal which contains a number of heartbeats is recognized.The method is based entirely on the temporal features(i.e., the dynamics) of ECG patterns, which contains complete information of ECG patterns. A dynamical model is employed to demonstrate the method, which is capable of generating synthetic ECG signals. Based on the dynamical model, the method is shown in the following two phases: the identification(training) phase and the recognition(test) phase. In the identification phase, the dynamics of ECG patterns is accurately modeled and expressed as constant RBF neural weights through the deterministic learning. In the recognition phase, the modeling results are used for ECG pattern recognition. The main feature of the proposed method is that the dynamics of ECG patterns is accurately modeled and is used for ECG pattern recognition. Experimental studies using the Physikalisch-Technische Bundesanstalt(PTB) database are included to demonstrate the effectiveness of the approach. | Xunde DONG Cong WANG Junmin HU Shanxing OU | 2014 | Control Theory and Technology2014，12，4： | 4 |
| 4 | Managerial ties, absorptive capacity, and innovation显示文摘 | Shanxing Gao Kai Xu Jianjun Yang | 2008 | Asia Pacific Journal of Management2008，，3： | 2 |
| 5 | The Stability of Strategic Alliances: Characteristics, Factors and Stages显示文摘 | Xu Jiang Yuan Li Shanxing Gao | 2008 | Journal of International Management2008，，14： | 1 |
| 6 | Managerial ties and firm innovation: Is knowledge creation amissing link? 显示文摘 | CHENGLI Shu ALBERT L Page GAO Shanxing | 2012 | Journal of Product Innovation Management2012，29，1： | 1 |
| 7 | Managerial ties,ab-sorptive capacity,and innovation显示文摘 | Gao Shanxing Xu Kai Yang Jianjun | | 0，，25： | 1 |
| 8 | ArsenatesorptionontwoChineseredsoilsevaluated with macroscopic measurements andextendedXrayabsorption finestructurespectroscopy显示文摘 | LuoL ZhangS ShanX JiangW ZhuY LiuT XieY McLarenRG | 2006 | Environmental Toxicology& Chemistry2006，25，12： | 1 |
| 9 | Mutations in the regulatory domain ofcystathionine beta synthase can functionally suppress patient derivedmutations incis 显示文摘 | ShanX DunbrackRL Jr Christopher SA | 2002 | Hum Mol Genet2002，10，： | 1 |
| 10 | The stability of strategic alliances= characteristics, factors and stages 显示文摘 | JIANG XU YUAN LI SHANXING GAO | 2008 | Journal of International Management2008，14，2： | 1 |
| 11 | Numerical simulation of neuronal spike patterns in a retinal network model显示文摘This study utilized a neuronal compartment model and NEURON software to study the effects of external light stimulation on retinal photoreceptors and spike patterns of neurons in a retinal network.Following light stimulation of different shapes and sizes,changes in the spike features of ganglion cells indicated that different shapes of light stimulation elicited different retinal responses.By manipulating the shape of light stimulation,we investigated the effects of the large number of electrical synapses existing between retinal neurons.Model simulation and analysis suggested that interplexiform cells play an important role in visual signal information processing in the retina,and the findings indicated that our constructed retinal network model was reliable and feasible.In addition,the simulation results demonstrated that ganglion cells exhibited a variety of spike patterns under different light stimulation sizes and different stimulation shapes,which reflect the functions of the retina in signal transmission and processing. | Lei Wang Shenquan Liu Shanxing Ou | 2011 | Neural Regeneration Research2011，6，16： | 1 |
| 12 | Interstitial myofibroblasts:Predictors of progression in membranous nephropathy显示文摘 | Roberts IS Burrows C Shanxs JH | 1997 | J Clin Pathol1997，50，7： | 1 |
| 13 | 显示文摘 | Song Peng Qing Hongwei Huang Shanxing | 2007 | Materials Science and Engineering B2007，138，： | 1 |
| 14 | Managerial Ties, Absorptive Capacity, and Innovation 显示文摘 | Gao Shanxing Xu Kai Yang Jianjun | 2008 | Asia Pacific Journal ofManagement2008，125，3： | 1 |
| 15 | Managing knowledge leakage in strategic alliances : The effects of trust and formalcontracts 显示文摘 | Xu Jiang Mei Li Shanxing Gao | 2013 | Industrial Marketing Management2013，42，6： | 1 |
| 16 | Managerial ties, absorptive capacity, and innovation 显示文摘 | Shanxing Gao Kai Xu Jianjun Yang | 2008 | Asia Pacific Journal of Management2008，9，3： | 1 |
| 17 | The stability of strategic alliances: Characteristics, factors and stages显示文摘 | Xu Jiang Yuan Li Shanxing Gao | 2008 | Journal of International Management2008，，： | 1 |
| 18 | The effect of insti-tutional ties on knowledge acquisition in uncertain environ-ment 显示文摘 | KaiXu KuoFeng Huang Shanxing Gao | 2012 | Asia Pacific Journal of Management2012，29，： | 1 |
| 19 | Adsorptionofmetalionsonlignin 显示文摘 | GuoX Y ZhangSZ ShanX Q | 2008 | Journalof Hazardous Materials2008，151，： | 1 |
| 20 | Technolog-ical innovation of firms in China : Past,present,and future显示文摘 | JianjunYang Huafang Lin Shanxing Gao | 2012 | Asia Pacific Journal of Management2012，29，3： | 1 |
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