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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | 枯草芽孢杆菌及饲料粗蛋白质水平对肉鸡生长性能和肉鸡肠道形态的影响显示文摘试验通过检测肉鸡生长性能、胴体品质、肉品质和消化道发育情况、回肠CP消化率,探究日粮中添加枯草芽孢杆菌对肉鸡粗蛋白质(CP)需求量的影响。试验选取720只1日龄肉鸡。设置2×2方阵设计,包括按照标准CP水平设置的对照组(CP 100),在标准基础上降低2%CP含量的试验组(CP 98);不添加枯草芽孢杆菌组及添加枯草芽孢杆菌0.2 g·kg^(-1)组(0.8×10~9cfu·g^(-1),将肉鸡随机分配到各组。每组6个重复,每个重复30只肉鸡。育雏料、生长期饲料和育肥期饲料均按照标准制定,饲料中添加枯草芽孢杆菌对生长性能无显著影响。然而,随着日粮中CP水平下降,体增重和饲料效率显著下降(P<0.05),饲料中添加枯草芽孢杆菌可显著提高肉鸡胴体品质(P<0.05)。添加枯草芽孢杆菌对肉品质无显著影响,然而,随着日粮中CP含量下降,肉的保水力显著下降(P<0.05);空肠隐窝显著变深(P<0.05),回肠CP消化率显著提高(P<0.05)。试验结果表明,日粮中添加枯草芽孢杆菌可改善空肠形态,减缓日粮中CP含量减少的不利影响。因此,益生菌的使用可改变胃肠道形态特征,提高CP的回肠消化率,提高饲料效率。 | Mahmoud K Z Obeidat B S Al-Sadi M Z Hatahet Sh R | 2017 | 饲料博览2017，0，1： | 5 |
| 4 | 限制卡路里摄入可抑制大鼠促进动脉衰老的炎症反应,保持年轻的表型显示文摘老化呈指数性增加典型心血管病的发病率和死亡率,这主要是由于动脉壁内分子、细胞和组织水平的动脉促炎变化。动物实验中,大鼠的卡路里限制(calorie restriction,CR)改善了动脉功能并延长了健康跨度和寿命。然而,CR如何影响大鼠动脉壁内分子,细胞和组织表型促炎变化仍有待阐明。该文选取随意喂食的344只年轻(6个月大)和老(24个月大)的Fischer大鼠,获取主动脉;另外选取1组在1个月大时开始只维持40%CR。 | 刘青 叶鹏 Wang MY Zhang L Zhu WQ Zhang J Kim SH Wang YS Ni L Telljohann R Monticone RE McGraw K Liu LJ Rafael de Cabo Lakatta EG | 2018 | 中华高血压杂志2018，26，11： | 3 |
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| 13 | Continued increase in the prevalence of asthma and atopy 显示文摘 | Downs SH Marks GB Sporik R | 2001 | Arch Dis Child2001，84，1： | 1 |
| 14 | Qualitative and quantitative determination of the major coumarins in Zushima by high performance liquid chrom atography with diode array detector and mass spectrometry 显示文摘 | SU J ZHANG C ZHANG W SH EN Y H LIH H LIU R H ZHANG X HU X J ZHANG W D | 2009 | J Chromatogr: A2009，1216，11： | 1 |
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