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| 1 | N-acetylcysteine attenuates alcohol-induced oxidative stess in rats显示文摘AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P<0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，4： | 9 |
| 2 | Role of immunotherapy in the treatment of allergic asthma显示文摘Allergen-specific immunotherapy(SIT) induces clinical and immunological tolerance as defined by persistence of clinical benefit and associated long-term immunological parameters after cessation of treatment. Although the efficacy of SIT has been shown in terms of reducing symptoms, medication consumption and ameliorating quality of life in both allergic rhinitis and asthma, there has long been some controversies about effectiveness of SIT in the treatment of allergic asthma. The type of allergen, the dose and protocol of immunotherapy, patient selection criteria, the severity and control of asthma, all are significant contributors to the power of efficacy in allergic asthma. The initiation of SIT in allergic asthma should be considered in case of coexisting of other allergic diseases such as allergic rhinitis, unacceptable adverse effects of medications, patient's preference to avoid long-term pharmacotherapy. Steroid sparing effect of SIT in allergic asthma is also an important benefit particularly in patients who have to use these drugs in high doses for a long-time. Symptomatic asthma is a risk factor for systemic reactions and asthma should be controlled at the time of administration of SIT. Both subcutaneous immunotherapy(SCIT) and sublingual immunotherapy(SLIT) have been found to be effective in patients with allergic asthma. Although the safety profile of SLIT seems to be better than SCIT, the results of some studies and meta-analyses suggest that the efficacy of SCIT may appear better and earlier than SLIT in children with allergic asthma. | Ayfer Yukselen Seval Guneser Kendirli | 2014 | World Journal of Clinical Cases2014，2，12： | 8 |
| 3 | N-acetylcysteine attenuates alcohol-induced oxidative stress in the rat显示文摘AIM: There is increasing evidence that alcohol-induced liverdamage may be associated with increased oxidative stress.We aimed to investigate free-radical scavenger effect of n-acetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups werefed with ethanol (6 g/kg/day, Group 1), ethanol and n-acetylcysteine (1 g/kg, Group 2), or isocaloric dextrose(control group, Group 3) for 4 weeks. Then animals weresacrificed under ether anesthesia, intracardiac blood andliver tissues were obtained. Measurements were performedboth in serum and in homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARSmethod. Glutathione peroxidase (GSH-Px) and superoxidedismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/Land 302 U/L,respectively) were higher than those in Group 2 (94 U/L and155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001 forboth). Serum and tissue levels of MDA in Group 1 (1.84 nmol/mL and 96 nmol/100 mg-protein) were higher than Group 2(0.91 nmol/mL and 64 nmol/100 mg-protein) and Group 3(0.94 nmol/mL and 49 nmol/100 mg-protein) (P<0.001 forboth). On the other hand, serum GSH-Px level in Group 1(8.21 U/g-Hb) was lower than Group 2 (16 U/g-Hb) andGroup 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levelsof SOD in Group 1 (11 U/mL and 26 U/100 mg-protein)were lower than Group 2 (18 U/mL and 60 U/100 mg-protein)and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001for both).CONCLUSION: This study demonstrated that ethanol-induced liver damage is associated with oxidative stress,and co-administration of n-acetylcysteine attenuates thisdamage effectively in rat model. | Resat Ozaras Veysel Tahan Seval Aydin Hafize Uzun Safiye Kaya Hakan Senturk | 2003 | World Journal of Gastroenterology2003，9，1： | 7 |
| 4 | Effect of acupuncture therapy on fracture healing in rats with femur fractures显示文摘OBJECTIVE: To investigate the effect of acupuncture therapy on fracture healing in rats with femur fractures.METHODS: A total of 10 groups were formed;control group, groups sacrificed on 7 th, 14 th, and 21 st days of fracture formation, groups to which acupuncture was applied for 7, 14, and 21 d, groups to which fracture and acupuncture were applied for 7,14, and 21 d. A transverse fracture line was formed in femurs of rats by using a Gigli saw. The Kirschner wire was driven retrograde down from the fracture line to proximal part of the bone and then, the fracture was fixed towards distal part. Acupuncture was applied to the rats for 7, 14, and 21 d as 4 sessions per week after formation of the fracture.RESULTS: Malondialdehyde(MDA), reduced glutathione(GSH) levels, catalase(CAT), glutathione-Stransferase(GST), superoxide dismutase(SOD), and glucose-6-phosphate dehydrogenase(G6 PD) activities were measured. Despite the increased MDA levels, G6 PD and SOD activities reduced during the fracture healing. There was a statistically significant increase in MDA, GSH levels, and G6 PD activity in fracture groups compared to control group, but CAT, GST, and SOD activities decreased. The use of acupuncture enhanced callus development and bone mineralization during bone healing.CONCLUSION: The acupuncture therapy can affect suppression of the effects of free oxygen radicals and regulation of the antioxidant enzyme activity in fracture healing. Thus, it is suggested that acupuncture treatment would be beneficial for fracture healing in order to eliminate the negative effects induced by oxygen free radicals. | Seval Yilmaz Emre Kaya Erhan Yilmaz Ahmet Kavakli Suleyman Gurbuz Mustafa Ozkaraca | 2020 | Journal of Traditional Chinese Medicine2020，40，2： | 6 |
| 5 | Protective effect of Nigella sativa oil against binge ethanolinduced oxidative stress and liver injury in rats显示文摘AIM: Nigella sativa L.(Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil(NSO) pretreatment on ethanol-induced hepatotoxicity in rats. METHOD: Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg-1, orally for 3 weeks, followed by oral ethanol(EtOH) administration(5 g·kg-1) every 12 h three times(binge model). RESULTS: Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde(MDA) levels. It decreased hepatic glutathione(GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO(5.0 mL·kg-1) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. CONCLUSION: NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration. | Seval Develi Betül Evran Esra Betül Kalaz Necla Koak-Toker Gül zdemirler Erata | 2014 | Chinese Journal of Natural Medicines2014，12，7： | 4 |
| 6 | The Effects of the Enriched Environment on Sympathetic Skin Response in Pentylenetetrazol-Kindled Rats显示文摘Epilepsy is a neurodegenerative disease that interrupts the normal electrical activity of the brain and promotes abnormal wiring in this organ.Epileptic seizures are often associated with significant changes in the functioning of the autonomic nervous system(ANS). | Nazan DOLU Seval KELOGLAN Soner BITIKTAS Setenay CUG | 2013 | Biomedical and Environmental Sciences2013，26，5： | 2 |
| 7 | A study of stability and bifurcation analysis in discrete-time predator—prey system involving the Allee effect显示文摘This paper deals with a discrete-time predator-prey system which is subject to an Allee effect on prey.We investigate the existence and uniqueness and find parametric conditions for local asymptotic stability of fixed points of the discrete dynamic system.Moreover,using bifurcation theory,it is shown that the system undergoes Neimark-Sacker bifurcation in a small neighborhood of the unique positive fixed point and an inv aria nt circle will appear.Then the direction of bifurcation is given.Furthermore,numerical analysis is provided to illustrate the theoretical discussions with the help of Matlab packages.Thus,the main theoretical results are supported with numerical simulations. | Seval Isik | 2019 | International Journal of Biomathematics2019，12，1： | 2 |
| 8 | Decolorization of textiledyes by fungal pellets显示文摘 | Ozfer Yesilada Dilek Asma Seval Cing | 2003 | Process Biochemistry2003，，38： | 1 |
| 9 | Rapid allelic discrimination from real-time DNA amplification显示文摘 | Sevall JS | 2001 | Methods2001，25，4： | 1 |
| 10 | Environmental basis of sus- tainable tourism along sensitive coastal areas principles and ap- plications显示文摘 | D Orhon H Gokqekus Seval Sozen | 2011 | Environmental Earth Sciences2011，，： | 1 |
| 11 | Oxidative stress in portal hypertension-induced rats with particular emphasis on nitric oxide and trace metals显示文摘AIM: To investigate the oxidative-stress-related changes in rats with portal hypertension with particular emphasis on nitric oxide (NO) and trace metals. METHODS: Cirrhosis was induced by partial portal vein ligation (PVL) in Wistar rats. The lipid peroxidation marker (malondialdehyde, MDA), antioxidant defense enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and agents known to have antioxidant features including nitric oxide (NO), zinc (Zn), copper (Cu) were determined both in serum and in liver tissue at 4 wk after surgery in PVL and sham-operated rats. Portal pressure of all experimental animals was measured. MDA was detected by thiobarbituric acid reactivity assay.SOD activity was determined by inhibition of nitroblue tetrazolium reduction with xanthine/xanthine oxidase used asa superoxide generator. CAT activity was determined by the breakdown of hydrogen peroxide. GSH concentrations were measured by using metaphosphoric acid for protein precipitation and 5'-5'-dithio-bis-2-nitrobenzoic acid for color development. NO was detected by the Griess method after reduction of nitrate to nitrite with nitrate reductase, and the concentrations of Zn and Cu were measured by a Shimadzu 680 AA atomic absorption spectrometer. Histopathological confirmation was done under light microscope. Statistical analyses were done by Student's t-test, and significance of the difference was tested by the unpaired Mann-Whitney test. P<0.05 was considered statistically significant.RESULTS: Histopathological studies confirmed PVL induced cirrhotic changes. There was a statistically significant difference in portal pressure between PVL and control groups (P<0.001). The results showed significant increases in the levels of MDA and NO in both tissue and serum (P<0.05 and P<0.001, respectively in tissue; P<0.001 for each in serum), and Zn only in tissue (P<0.001)in rats with PVL compared with sham-operated rats. Besides, PVL rats exhibited reduced plasma and tissue GSH, CAT, SOD (P<0.001 for each). Serum and tissue Cu concentration did not change.CONCLUSION: Our findings suggest that PVL in rats induces important biochemical and molecular changes related to oxidative stress in the liver. | Titiz Izzet Krand Osman Unal Ethem Yavuz Nihat Kusaslan Ramazan Dogan Mustafa Uzun Hafize Kiziler Ali Riza Aydemir Birsen Genc Habibe Aydin Seval Simsek Gonul | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 12 | Regulation of intedeukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis显示文摘 | Luk J Seval Y Kayisli UA | 2005 | J Clin Endocrinol Metab2005，90，3： | 1 |
| 13 | Storage location assignment and order picking optimization in the automotive industry 显示文摘 | Seval Ene Nursel Ozturk | 2012 | The International Journal of Advanced Manufacturing Technology2012，60，58： | 1 |
| 14 | Current and future implica- tions of basic and translational research on amyloid-beta pep- tide production and removal pathways显示文摘 | Bohm C Chen F Sevalle J | 2015 | Mol Cell Neurosci2015，2，1： | 1 |
| 15 | Potential effects of L-NAME on alcohol-induced oxidative stress显示文摘AIM: Nitric oxide (NO) is a highly reactive oxidant synthesized from L-arginine by nitric oxide synthase (NOS). NO may cause injury through the generation of potent radicals. Nwnitro-L-arginine methyl ester (L-NAME) is a non-selective inhibitor of NOS. We aimed to evaluate whether L-NAME treatment had protective effects against oxidative stress in rats intragastrically fed with ethanol during a 4 wk-period.METHODS: Thirty-six male Wistar rats were divided into 3 equal groups: group 1 (control group-isocaloric dextrose was given), group 2 (6 g/kg.d ethanol-induced group) and group 3 (both ethanol 6 g/kg.d and L-NAME 500 mg/L in drinking water-given group). Animals were sacrificed at the end of 4 wk-experimental period, and intracardiac blood and liver tissues were obtained. Biochemical measurements were performed both in plasma and in homogenized liver tissues. Alanine amino transferase (ALT), aspartate amino transferase (AST), malondialdehyde (MDA), NO, superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) levels were measured by spectrophotometry.RESULTS: ALT and AST in group 2 (62 U/L and 128 U/L,respectively) were higher than those in group 1 (24 U/L and 38 U/L) and group 3 (37 U/L and 81 U/L) (P<0.001 for both).Plasma and tissue levels of MDA in group 2 (4.66 μmol/L and 0.55 nmol/mg protein) were higher than in group 1 (2.65 μmol/L and 0.34 nmol/mg protein) and group 3 (3.43 μmol/L and 0.36 nmol/mg protein) (P<0.001 for both). Plasma and liver tissue levels of NO in group 2 (54.67 μmol/L and 586.50 nmol/mg protein) were higher than in group 1 (34.67 μmol/L and 435.33 nmol/mg protein)and group 3 (27.50 μmol/L and 412.75 nmol/mg protein )(P<0.001 for both). Plasma and liver tissue SOD activities in group 2 (15.25 U/mL and 5.38 U/ mg protein,respectively) were lower than in group 1 (20.00 U/mL and 8.13 U/mg protein) and group 3 (19.00 U/mL and 6.93 U/mg protein) (P<0.001 for both). Plasma and liver tissue CAT activities in group 2 (145 U/mL and 37 U/ mg protein,respectively) were lower than in group 1 (176 U/mL and 73 U/mg protein) and group 3 (167 U/mL and 61 U/mg protein) (P<0.001 for both). Meanwhile, erythrocytes and liver tissue levels of GSH in group 2 (4.12 mg/g Hb and 5.38 nmol/mg protein, respectively) were lower than in group 1 (5.52 mg/g Hb and 4.49 nmol/mg protein) and group 3 (5.64 mg/g Hb and 4.18 nmol/mg protein) (P<0.001 for both).CONCLUSION: Our findings show that L-NAME may produce a restorative effect on ethanol-induced liver damage via decreasing oxidative stress and increasing antioxidant status. | Hafize Uzun Gonul Simsek Seval Aydin Ethem Unal Yesari Karter Nermin Karaturan Yelmen Suphi Vehid Asl Curgunlu Safiye Kaya | 2005 | World Journal of Gastroenterology2005，11，4： | 1 |
| 16 | Regulation of interleukin-8 expression in human endometrial endothelial cells: a potential mechanism for the pathogenesis of endometriosis 显示文摘 | Luk J Seval Y Kayisli UA | 2005 | Clin Endocrlnol Metab2005，90，3： | 1 |
| 17 | Utilization of axillary bra- chial plexus block in the postoperative rehabilitation of intra-artic- ular fractures of the distal humerus显示文摘 | Semsi MA Seval I Mahmut K | 2010 | Acta Orthop Traumatol Turc2010，44，2： | 1 |
| 18 | Regulation of Monocyte Chemotac-tic Protein-1 Expression in Human Endometrial Endothelial Cells bySex Steroids:A Potential Mechanism for Leukocyte Recruitment inEndometriosis显示文摘 | Luk J Seval Y Ulukus M | 2010 | Reproductive Sciences2010，17，3： | 1 |
| 19 | Storage location assignment and order pick- ing optimization in the automotive industry显示文摘 | Seval Ene Nursel 0zturk | 2012 | International Journal of Advanced Manufacturing Technology2012，60，： | 1 |
| 20 | Inhibitory effect of Bursa propolis on dental caries formation in rats inoculated with streptococcus sobrinus显示文摘 | Seval O | 2004 | Turk J Zool2004，28，： | 1 |
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