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| 1 | Exploring the structural and functional effect of pRB by significant nsSNP in the coding region of RB1 gene causing retinoblastoma显示文摘In this study,we identified the most deleterious nsSNP in RB1 gene through structural and functional properties of its protein (pRB) and investigated its binding affinity with E2F-2.Out of 956 SNPs,we investigated 12 nsSNPs in coding region in which three of them (SNPids rs3092895,rs3092903 and rs3092905) are commonly found to be damaged by I-Mutant 2.0,SIFT and PolyPhen programs.With this effort,we modeled the mutant pRB proteins based on these deleterious nsSNPs.From a comparison of total energy,stabilizing residues and RMSD of these three mutant proteins with native pRB protein,we identified that the major mutation is from Glutamic acid to Glycine at the residue position of 746 of pRB.Further,we compared the binding efficiency of both native and mutant pRB (E746G) with E2F-2.We found that mutant pRB has less binding affinity with E2F-2 as compared to native type.This is due to sixteen hydrogen bonding and two salt bridges that exist between native type and E2F-2,whereas mutant type makes only thirteen hydrogen bonds and one salt bridge with E2F-2.Based on our investigation,we propose that the SNP with an id rs3092905 could be the most deleterious nsSNP in RB1 gene causing retinoblastoma. | Rajasekaran R Rao Sethumadhavan | 2010 | Science China(Life Sciences)2010，53，2： | 4 |
| 2 | Cytoeompatibility of various metal and development of new titanium alloys for medical implants 显示文摘 | YOSHIMISTSU O SETHUMADHAVAN R TETSUYA T | 1998 | Materials Science and Engineering A1998，243，12： | 1 |
| 3 | Performance prediction and validation of equilibrium modeling for gasification of cashew nut shell char显示文摘 | RAMANAN M V LAKSHMANAN E SETHUMADHAVAN R | 2008 | Brazilian Journal of Chemical Engineering2008，25，3： | 1 |
| 4 | Computational and Structural Investigation of Deleterious Functional SNPs in Breast Cancer BRCA2 Gene显示文摘In this work, we have analyzed the genetic variation that can alter the expression and the function in BRCA2 gene using computational methods. Out of the total 534 SNPs, 101 were found to be non synonymous (nsSNPs). Among the 7 SNPs in the untranslated region, 3 SNPs were found in 5′ and 4 SNPs were found in 3′ un-translated regions (UTR). Of the nsSNPs 20.7% were found to be damaging by both SIFT and PolyPhen server among the 101 nsSNPs investigated. UTR resource tool suggested that 2 SNPs in the 5′ UTR region and 4 SNPs in the 3′ UTR regions might change the protein expression levels. The mutation from asparagine to isoleucine at the position 3124 of the native protein of BRCA2 gene was most deleterious by both SIFT and PolyPhen servers. A structural analysis of this mutated protein and the native protein was made which had an RMSD value of 0.301 nm. Based on this work, we proposed that this most deleterious nsSNP with an SNPid rs28897759 is an important candidate for the cause of breast cancer by BRCA2 gene. | Rajasekaran R George Priya Doss Sudandiradoss C Ramanathan K Rituraj Purohit Rao Sethumadhavan | 2008 | 生物工程学报2008，24，5： | 1 |
| 5 | Molecular Dynamic Simulation Reveals Damaging Impact of RAC1 F28L Mutation in the Switch I Region显示文摘 | Kumar A Rajendran V Sethumadhavan R | 2013 | PloS One2013，8，77： | 1 |
| 6 | Solar cookers with and without thermal storage-A review显示文摘 | Muthusivagami R M Velraj R Sethumadhavan R | 2010 | Renewable and Sustainable Energy Reviews2010，14，2： | 1 |
| 7 | CEP proteins:the knights of centrosome dynasty显示文摘 | Kumar A Rajendran V Sethumadhavan R | 2013 | Protoplasma2013，250，5： | 1 |
| 8 | Identification and in silieo analysis of functional SNPs of the BRCA1 gene显示文摘 | Rajasekaran R Sudandiradoss C Doss C O Sethumadhavan R | 2007 | Genomics2007，90，： | 1 |
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