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| 1 | Utility of flexible fiberoptic bronchoscopy for critically ill pediatric patients:A systematic review显示文摘AIM: To investigate the diagnostic yield, therapeutic efficacy, and rate of adverse events related to flexible fiberoptic bronchoscopy(FFB) in critically ill children. METHODS: We searched Pub Med, SCOPUS, OVID, and EMBASE databases through July 2014 for English language publications studying FFB performed in the intensive care unit in children < 18 years old. We identified 666 studies, of which 89 full-text studies were screened for further review. Two reviewers independently determined that 27 of these studies met inclusion criteria and extracted data. We examined the diagnostic yield of FFB among upper and lower airway evaluations, as well as the utility of bronchoalveolar lavage(BAL). RESULTS: We found that FFB led to a change in medical management in 28.9%(range 21.9%-69.2%) of critically ill children. The diagnostic yield of FFB was 82%(range 45.2%-100%). Infectious organisms were identified in 25.7%(17.6%-75%) of BALs performed, resulting in a change of antimicrobial management in 19.1%(range: 12.2%-75%). FFB successfully reexpanded atelectasis or removed mucus plugs in 60.3%(range: 23.8%-100%) of patients with atelectasis. Adverse events were reported in 12.9%(range: 0.5%-71.4%) of patients. The most common adverse effects of FFB were transient hypotension, hypoxia and/or bradycardia that resolved with minimal intervention, such as oxygen supplementation or removal of the bronchoscope. Serious adverse events were uncommon; 2.1% of adverse events required intervention such as bag-mask ventilation or intubation and atropine for hypoxia and bradycardia, normal saline boluses for hypotension, or lavage and suctioning for hemorrhage. CONCLUSION: FFB is safe and effective for diagnostic and therapeutic use in critically ill pediatric patients. | Aida Field-Ridley Viyeka Sethi Shweta Murthi Kiran Nandalike Su-Ting T Li | 2015 | World Journal of Critical Care Medicine2015，4，1： | 12 |
| 2 | The epithelial cell and lung cancer: the link between chronic obstructive pulmonary disease and lung cancer 显示文摘 | Rooney C Sethi T | 2011 | Respiration2011，81，2： | 1 |
| 3 | Infection in the pathogenesis and course of chronic obstructive pulmonary disease 显示文摘 | Sethi S Murphy T F | 2008 | N Engl J Med2008，359，22： | 1 |
| 4 | Diels-Alder Reactions in Room-ternprature ionic liquids显示文摘 | Fischer T Sethi A Wehon T etal | 1990 | Tetrahedron letters1990，40，4： | 1 |
| 5 | The role of extracellular matrix in smallcell lung cancer显示文摘 | Rintoul RC Sethi T | 2001 | Lancet Oncol2001，2，3： | 1 |
| 6 | Extracellular matrix regulation of drugresistance in small-cell lung cancer显示文摘 | Rintoul RC Sethi T | 2002 | Clin Sci2002，102，4： | 1 |
| 7 | Extracellular matrix regulation of drug resis- tance in small-cell lung cancer显示文摘 | Rintoul RC Sethi T | 2002 | Clin Sci(Lond)2002，102，4： | 1 |
| 8 | Diets-alder reactions in room-temperature ionic liquids 显示文摘 | FISCHER T SETHI A WELTON T | 1999 | Tetra- hedron Letters1999，40，： | 1 |
| 9 | The role of extraeellular matrix in small-cell lung cancer 显示文摘 | Rintoul RC Sethi T | 2001 | Lancet Oncology2001，2，7： | 1 |
| 10 | 显示文摘 | Sethi A Welton T | 1999 | Tetrahedron Letter1999，40，4： | 1 |
| 11 | Liraglutide in type 2 diabetes mellitus 显示文摘 | Baruah MP Cbaudhury T Sethi BK | 2012 | J Indian Med Assoc2012，110，： | 1 |
| 12 | Extracellular matrix proteins protect small cell lung cancer cells against:a mechanism for small cell lung cancer growth and drug resistance in vivo显示文摘 | SETHI T RINTOUL RC MOORE SM | 1999 | Nat Med1999，5，6： | 1 |
| 13 | Bacterial infection in chronic obstructive pulmonary disease in 2000:a state-of-the-art review显示文摘 | Sethi S Murphy T F | 2001 | Clin Microbiol Rev2001，14，： | 1 |
| 14 | 经皮冠状动脉介入后阻塞性睡眠呼吸暂停与心血管事件的关系显示文摘目前关于阻塞性睡眠呼吸暂停(obstructive sleepapnea,OSA)对冠状动脉疾病患者的预后意义的大型队列研究数据匮乏。该研究假设OSA可预测行经皮冠状动脉介入治疗(percutaneous coronary intervention.PCI)患者未来主要不良心脏和脑血管事件(major adverse cardiac and cerebrovascularevents,MACCE)。方法:睡眠及支架研究是一项前瞻性、多中心注册研究,纳入2011年12月和2014年4月来自5个国家经PCI治疗成功的患者1748例。 | Lee CH Sethi R Li R Ho HH Hein T Jim MH Loo G Koo CY Gao XF Chandra S Yang XX Furlan SF Ge Z Mundhekar A Zhang WW Ucha CH Kharwar RB Chan PF Chen SL Chan MY Richards A Tan HC Ong TH Roldan G Tai BC Drager LF Zhang JJ 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 1 |
| 15 | Conversion of non-coking coal into coking coal with methane and with hydrogen 显示文摘 | Ralph T Yang Dhanwant S Sethi Meyer Steinberg | 1978 | Fuel1978，57，5： | 1 |
| 16 | Extracellular matrix proteins protect small cell lung cancer cells against:a mechanism for small cell lung cancer growth and drug resistance in vivo显示文摘 | SETHI T RINTOUL R C MOORE S M | 1999 | Nat Med1999，5，6： | 1 |
| 17 | The regulation of inflammation by galectin-3显示文摘 | Henderson NC Sethi T | 2009 | Immunol Rev2009，230，1： | 1 |
| 18 | Extracellular Matrix Proteins Protect Small Cell Lung Cancer Cells Against Apoptosis : A Mechanism for Small Cell Lung Cancer Growth and Drug Re?sistance in Vivo显示文摘 | Sethi T Rintoul R C Moore S M et a1 | 1999 | Nature Medicine1999，5，6： | 1 |
| 19 | Bilateral juvenile glaucoma with iridotrabecular dysgenesis,congenital ectropion uveae,and thickened corneal nerves显示文摘 | Sethi HS Pal N Dada T | 2005 | Eye2005，19，： | 1 |
| 20 | Prevention of capsular block syndrome显示文摘 | Sethi H Dada T | 2002 | J Cataract Refract Surg2002，28，： | 1 |
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