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| 1 | Solid lipid nanoparticles delivering anti-inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model显示文摘AIM To improve anti-inflammatory activity while reducing drug doses, we developed a nanoformulation carrying dexamethasone and butyrate.METHODS Dexamethasone cholesteryl butyrate-solid lipid nanoparticles(Dx Cb-SLN) were obtained with the warm microemulsion method. The anti-inflammatory activity of this novel nanoformulation has been investigated in vitro(cell adhesion to human vascular endothelial cells and pro-inflammatory cytokine release by lipopolysaccharideinduced polymorphonuclear cells) and in vivo(disease activity index and cytokine plasma concentrations in a dextran sulfate sodium-induced mouse colitis) models. Each drug was also administered separately to compare its effects with those induced by their co-administration in SLN at the same concentrations.RESULTS Dx Cb-SLN at the lowest concentration tested(Dx 2.5 nmol/L and Cb 0.1 μmol/L) were able to exert a more than additive effect compared to the sum of the individual effects of each drug, inducing a significant in vitro inhibition of cell adhesion and a significant decrease of pro-inflammatory cytokine(IL-1β and TNF-α) in both in vitro and in vivo models. Notably, only the Dx Cb nanoformulation administration was able to achieve a significant cytokine decrease compared to the cytokine plasma concentration of the untreated mice with dextran sulfate sodium-induced colitis. Specifically, Dx Cb-SLN induced a IL-1β plasma concentration of 61.77% ± 3.19%, whereas Dx or Cb used separately induced a concentration of 90.0% ± 2.8% and 91.40% ± 7.5%, respectively; Dx Cb-SLN induced a TNF-α plasma concentration of 30.8% ± 8.9%, whereas Dx or Cb used separately induced ones of 99.5% ± 4.9% and 71.1% ± 10.9%, respectively.CONCLUSION Our results indicate that the co-administration of dexamethasone and butyrate by nanoparticles may be beneficial for inflammatory bowel disease treatment. | Chiara Dianzani Federica Foglietta Benedetta Ferrara Arianna Carolina Rosa Elisabetta Muntoni Paolo Gasco Carlo Della Pepa Roberto Canaparo Loredana Serpe | 2017 | World Journal of Gastroenterology2017，23，23： | 3 |
| 2 | l -Carnitine: An adequate supplement for a multi-targeted anti-wasting therapy in cancer显示文摘 | Sílvia Busquets Roberto Serpe Míriam Toledo Angélica Betancourt Enrica Marmonti Marcel Orpí Fabrizio Pin Eva Capdevila Clelia Madeddu Francisco J. López-Soriano Giovanni Mantovani Antonio Macciò Josep M. Argilés | 2012 | Clinical Nutrition2012，，6： | 2 |
| 3 | CD4+ T,but not CD8+ or B,lymphocytes mediate facial motoneuron survival after facial nerve transection显示文摘 | Serpe CJ Coers S Sanders VM | 2003 | Brain Behav Immun2003，17，5： | 1 |
| 4 | Visible lightphoto- degradation of phenol on MWNTs TiOz compositecatalysts prepared by a modified sol-gel method显示文摘 | WANG W D SERP P KALCK P | 2005 | Journalof Molecular Catalysis A= Chemical2005，235，12： | 1 |
| 5 | CD4+T,but not CD8+or B,lymphocytes mediate facial motoneuron survival after facial nerve transection显示文摘 | Serpe CJ Coers S Sanders VM | 2003 | Brain Rehav Immun2003，17，5： | 1 |
| 6 | Effect of Yariv phenylglycosides on Rosa cell suspensions: evidence for the involvement of arabinogalactan proteins in cell proliferation显示文摘 | Serpe M D Nothnagel E A | 1994 | Planta1994，193，： | 1 |
| 7 | Hollow thermorespon- sire microgels显示文摘 | Nayak S Gan D J Serpe M J | 2005 | Small2005，1，4： | 1 |
| 8 | Photoswitchable microlens arrays显示文摘 | Kim J Serpe M J Lyon L A | 2005 | Angew Chem lnt Ed2005，44，13： | 1 |
| 9 | Carbon nanotubes and nanofibers in catalysis 显示文摘 | Serp P Corrias M Kalck P | 2003 | Applied Catalysis a-General2003，253，： | 1 |
| 10 | Brain-derived neurotrophic factor supports facial motoneuron survival after facial nerve transection in immunodeficient mice显示文摘 | Serpe CJ Byram SC Sanders VM | | 0，，02： | 1 |
| 11 | Phenotype of CD4+T cell subsets that develop following mouse facial nerve axotomy显示文摘 | Xin J Wainwright DA Serpe CJ | 2008 | Brain Behav Immun2008，22，4： | 1 |
| 12 | Effects of safety climate on safety norm violations : Exploring the mediating role of attitudinal ambiva- lence toward personal perfective equipment显示文摘 | Cavazza N Serpe A | 2009 | Journal of Safety Research2009，40，4： | 1 |
| 13 | Chemical vapor deposition methods for the controlled preparation of supported catalytic materials 显示文摘 | Serp P Kalck P | 2002 | Chem Rev2002，102，： | 1 |
| 14 | A chemical vapor deposition process for the production of carbon nanospheres显示文摘 | Serp P Feurer R Kalck P | 2001 | Carbon2001，39，4： | 1 |
| 15 | Graphene-based materials for catalysis 显示文摘 | MACHADO B F SERP P | 2012 | Catal Sci Technol2012，2，： | 1 |
| 16 | Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell 1 ine 显示文摘 | Serpe L Catalano MG Cavalli R | 2004 | Eur J Pharm Biopharm2004，58，3： | 1 |
| 17 | Sonodynamic antimicrobial chemo- therapy: First steps towards a sound approach for microbe inactivation显示文摘 | Serpe L Giuntini F | 2015 | J Photochem Photobiol B Biology2015，150，： | 1 |
| 18 | Synergistic effect between few layer graphene and carbon nanotube supports for palladium catalyzing electrochemical oxidation of alcohols显示文摘Few layer graphene (FLG), multi-walled carbon nanotubes (CNTs) and a nanotube-graphene composite (CNT-FLG) were used as supports for palladium nanoparticles. The catalysts, which were characterized by transmission electron microscopy, Raman spectroscopy and X-ray diffraction, were used as anodes in the electrooxidation of ethanol, ethylene glycol and glycerol in half cells and in passive direct ethanol fuel cells. Upon Pd deposition, a stronger interaction was found to occur between the metal and the nanotube-graphene composite and the particle size was significantly smaller in this material (6.3 nm), comparing with nanotubes and graphene alone (8 and 8.4 nm, respectively). Cyclic voltammetry experiments conducted with Pd/CNT, Pd/FLG and Pd/CNT-FLG in 10 wt% ethanol and 2 M KOH solution, showed high specific currents of 1.48, 2.29 and 2.51 mA μg-1 Pd , respectively. Moreover, the results obtained for ethylene glycol and glycerol oxidation highlighted the excellent electrocatalytic activity of Pd/CNT-FLG in terms of peak current density (up to 3.70 mA μg-1 Pd for ethylene glycol and 1.84 mA μg-1 Pd for glycerol, respectively). Accordingly, Pd/CNT-FLG can be considered as the best performing one among the electrocatalysts ever reported for ethylene glycol oxidation, especially considering the low metal loading used in this work. Direct ethanol fuel cells at room temperature were studied by obtaining power density curves and undertaking galvanostatic experiments. The power density outputs using Pd/CNT, Pd/FLG and Pd/CNT-FLG were 12.1, 16.3 and 18.4 mW cm2 , respectively. A remarkable activity for ethanol electrooxidation was shown by Pd/CNT-FLG anode catalyst. In a constant current experiment, the direct ethanol fuel cell containing Pd/CNT-FLG could continuously deliver 20 mA cm2 for 9.5 h during the conversion of ethanol into acetate of 30%, and the energy released from the cell was about 574 J. | Bruno F. Machado Andrea Marchionni Revathi R. Bacsa Marco Bellini Julien Beausoleil Werner Oberhauser Francesco Vizza Philippe Serp | 2013 | Journal of Energy Chemistry2013，22，2： | 1 |
| 19 | Carbon Nanotubes and Nanofi-bers in Catalysis 显示文摘 | Serp P Corrias M Kalck P | 2003 | Appl Catal A: Gen2003，253，2： | 1 |
| 20 | Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice显示文摘 | Serpe CJ Tetzlaff JE Coers S | | 0，，： | 1 |
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