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| 1 | Return to sport following tibial plateau fractures: A systematic review显示文摘AIM To systemically review all studies reporting return to sport following tibial plateau fracture, in order to provide information on return rates and times to sport, and to assess variations in sporting outcome for different treatment methods.METHODS A systematic search of CINAHAL, Cochrane, EMBASE, Google Scholar, MEDLINE, PEDro, Scopus, SPORTDiscus and Web of Science was performed in January 2017 using the keywords 'tibial', 'plateau', 'fractures', 'knee', 'athletes', 'sports', 'non-operative', 'conservative', 'operative', 'return to sport'. All studies which recorded return rates and times to sport following tibial plateau fractures were included. RESULTS Twenty-seven studies were included: 1 was a randomised controlled trial, 7 were prospective cohort studies, 16 were retrospective cohort studies, 3 were case series. One study reported on the outcome of conservative management(n = 3); 27 reported on the outcome of surgical management(n = 917). Nine studies reported on Open Reduction Internal Fixation(ORIF)(n = 193), 11 on Arthroscopic-Assisted Reduction Internal Fixation(ARIF)(n = 253) and 7 on Frame-Assisted Fixation(FRAME)(n = 262). All studies recorded 'return to sport'rates. Only one study recorded a 'return to sport' time. The return rate to sport for the total cohort was 70%. For the conservatively-managed fractures, the return rate was 100%. For the surgically-managed fractures, the return rate was 70%. For fractures managed with ORIF, the return rate was 60%. For fractures managed with ARIF, the return rate was 83%. For fractures managed with FRAME was 52%. The return rate for ARIF was found to be significantly greater than that for ORIF(OR 3.22, 95%CI: 2.09-4.97, P < 0.001) and for FRAME(OR 4.33, 95%CI: 2.89-6.50, P < 0.001). No difference was found between the return rates for ORIF and FRAME(OR 1.35, 95%CI: 0.92-1.96, P = 0.122). The recorded return time was 6.9 mo(median), from a study reporting on ORIF.CONCLUSION Return rates to sport for tibial plateau fractures remain limited compared to other fractures. ARIF provides the best return rates. There is limited data regarding return times to sport. Further research is required to determine return times to sport, and to improve return rates to sport, through treatment and rehabilitation optimisation. | Greg A J Robertson Seng J Wong Alexander M Wood | 2017 | World Journal of Orthopedics2017，8，7： | 10 |
| 2 | Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer:The role of inflammation显示文摘Chemotherapy-induced diarrhea(CID)is a common and often severe side effect experienced by colorectal cancer(CRC)patients during their treatment.As chemotherapy regimens evolve to include more efficacious agents,CID is increasingly becoming a major cause of dose limiting toxicity and merits further investigation.Inflammation is a key factor behind gastrointestinal(GI)toxicity of chemotherapy.Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in the small intestine and colonic mucosa.Here we review the current understanding of the mechanisms behind GI toxicity and the mucositis associated with systemic treatment of CRC.Insights into the inflammatory response activated during this process gained from various models of GI toxicity are discussed.The inflammatory processes contributing to the GI toxicity of chemotherapeutic agents are increasingly being recognised as having an important role in the development of anti-tumor immunity,thus conferring added benefit against tumor recurrence and improving patient survival.We review the basic mechanisms involved in the promotion of immunogenic cell death and its relevance in the treatment of colorectal cancer.Finally,the impact of CID on patient outcomes and therapeutic strategies to prevent or minimise the effect of GI toxicity and mucositis are discussed. | Chun Seng Lee Elizabeth J Ryan Glen A Doherty | 2014 | World Journal of Gastroenterology2014，20，14： | 10 |
| 3 | Particle migration after transurethral injection of carbon coated beads for stress urinary incontinence显示文摘 | Pannek J Brands FH Senge T | 2001 | J Urol2001，166，： | 1 |
| 4 | Ef- fects of the heavy metal Cu^2+ on growth, development, and population dynamics of spodoptera litura (Lepidoptera: Noctu- idae) 显示文摘 | HUANG D KONG J SENG Y | 2012 | Journal of Economic Entomol- ogy2012，105，1： | 1 |
| 5 | Identifying three types of violent offenders and predicting violent recidivism while on probation显示文摘 | Loretta J Stalans Paul R Yarnold Magnus Seng | 2004 | Law and Hunan Behavior2004，9，33： | 1 |
| 6 | Retroposition in a family of carcinoma-associated antigen genes 显示文摘 | Liunebnach A J Seng BA WUS | 1993 | Mol Cell Biol1993，13，3： | 1 |
| 7 | A review of bio-metric technology along with trends and prospects 显示文摘 | UNAR J A SENG W C ABBASI A | 2014 | Pattern Recognition2014，47，8： | 1 |
| 8 | DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma显示文摘 | Seng T J Currey N Cooper W A | 2008 | Br J Cancer2008，99，2： | 1 |
| 9 | Versatility of the free anterolat- eral thigh flap for reconstruction of soft-tissue defects: review of 140 cases显示文摘 | Kuo YR Seng Feng J Kuo FM | 2002 | Ann Plast Surg2002，48，2： | 1 |
| 10 | Low-temperature chromium (Ⅵ) biotransformation in soil with varying electron acceptors显示文摘 | T seng J K Bielefeldt A R | 2002 | Environ Qual2002，31，5： | 1 |
| 11 | Tests for building confidence in system dynamics models显示文摘 | Forrester J Senge P | 1980 | TIMS Studies in the Management Sciences1980，，14： | 1 |
| 12 | Carrier detection and prenatal diagnosisof alpha - thalassemia of Southeast Asian deletion by polymerase chain reaction显示文摘 | TM T seng L H H sieh F J | 1992 | Human Genetics1992，8，3： | 1 |
| 13 | Indices of novelty for emerging topic detection 显示文摘 | Tu Y N Seng J L | 2012 | Information Processing & Management2012，48，2： | 1 |
| 14 | Development of a rapid,sensitive and specific diagnostic assay for fish Aquareovirus based on RT-PCR显示文摘 | Seng E K Fang Q Lam T J | 2004 | J Virol Methods2004，118，： | 1 |
| 15 | Semi Fragile Watermark with Self Authentication and Self Recovery 显示文摘 | Seng W C Du J Pham B | 2009 | Malaysian Journal of Computer Science(S0127-9084)2009，22，1： | 1 |
| 16 | Free-standing V2O5 electrode for flexible lithium ion batteries显示文摘 | Seng K H Liu J Guo Z P | | 0，，05： | 1 |
| 17 | Wild plants in the diet of Arhorchin Mongol Herdsmen in Inner Mongolia 显示文摘 | Khasbagab Hu Y H Seng J P | 2000 | Economic Botany2000，54，4： | 1 |
| 18 | Therapeutic keratoplasty for advanced suppurative keratitis 显示文摘 | SENG J ANGUS SCOTF PRATHIBHA JANARDANAN | 2007 | Am J Ophthalmol2007，143，： | 1 |
| 19 | Cumulative viral evolutionary changes in chronic hepatitis B virus infection precedes hepatitis B e antigen seroconversion显示文摘 | Yan Cheng Stephane Guindon Allen Rodrigo Lin Ying Wee Masafumi Inoue Alex J V Thompson Stephen Locarnini Seng Gee Lim | 2013 | Gut2013，，9： | 1 |
| 20 | Gradient-index Polymer Fibers Prepared by Extrusion 显示文摘 | Ho B C Chen J H Chen W C Chang Y H Yang S Y Chen J J Seng T W | 1995 | Polymer Journal1995，27，31： | 1 |
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