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| 1 | 听力障碍与轻度认知功能障碍患病率之间的关系显示文摘世界卫生组织(WHO)于2012年将痴呆症列为公共卫生优先事项,预计到2050年,全球痴呆症患病人数将增加到1.315亿人。轻度认知障碍(mild cognitive impairment,MCI)是介于认知功能正常和痴呆症之间的中间阶段。MCI患者在相对较短时间内进展为痴呆症的比例很高,而且MCI康复人群中再次发生MCI或痴呆症的比例要高于之前未患MCI的人。发掘MCI的相关风险因素可有效进行早期干预,预防或显著延迟痴呆症的发生。 | 丁永军 杨蕊 陈始明(审校) Miyake Y Tanaka K Senba H | 2021 | 听力学及言语疾病杂志2021，29，2： | 3 |
| 2 | Induction of CD69 expression by cag PAI-positive Helicobacter pylori infection显示文摘AIM: To investigate and elucidate the molecular mechanism that regulates inducible expression of CD69 by Helicobacter pylori (H. pylori ) infection. METHODS: The expression levels of CD69 in a T-cell line, Jurkat, primary human peripheral blood mononuclear cells (PBMCs), and CD4 + T cells, were assessed by immunohistochemistry, reverse transcription polymerase chain reaction, and flow cytometry. Activation of CD69 promoter was detected by reporter gene. Nuclear factor (NF)-κB activation in Jurkat cells infected with H. pylori was evaluated by electrophoretic mobility shift assay. The role of NF-κB signaling in H. pylori-induced CD69 expression was analyzed using inhibitors of NF-κB and dominant-negative mutants. The isogenic mutants with disrupted cag pathogenicity island (cag PAI) and virD4 were used to elucidate the role of cag PAI-encoding type Ⅳ secretion system and CagA in CD69 expression.RESULTS: CD69 staining was detected in mucosal lymphocytes and macrophages in specimens of pa- tients with H. pylori-positive gastritis. Although cag PAI- positive H. pylori and an isogenic mutant of virD4 induced CD69 expression, an isogenic mutant of cag-PAI failed to induce this in Jurkat cells. H. pylori also induced CD69 expression in PBMCs and CD4 + T cells. The activation of the CD69 promoter by H. pylori was mediated through NF-κB. Transfection of dominant-negative mutants of IκBs, IκB kinases, and NF-κB-inducing kinase inhibited H. pylori-induced CD69 activation. Inhibitors of NF-κB suppressed H. pylori-induced CD69 mRNA expression. CONCLUSION: The results suggest that H. pylori induces CD69 expression through the activation of NF-κB. cagPAI might be relevant in the induction of CD69 expression in T cells. CD69 in T cells may play a role in H. pylori-induced gastritis. | Naoki Mori Chie Ishikawa Masachika Senba | 2011 | World Journal of Gastroenterology2011，17，32： | 2 |
| 3 | Hydrogen and enthanol production from glycerol - containing wastes were dischargod after manufacturing process 显示文摘 | Ito T Nakashimada Y Senba K | 2005 | Journal of Bioscience and Bioengineering2005，100，30： | 1 |
| 4 | Japanese spotted feverdefinitively diagnosed by the polymerase chain reaction method显示文摘 | Kodama K Senba T Yamauchi H | | 0，，03： | 1 |
| 5 | Expression of c-fos, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate 显示文摘 | Kinoshita Y Ueyama T Senba E | 2001 | J Neurotrauma2001，18，4： | 1 |
| 6 | Expression of c-fox, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA modification by magnesium sulfate显示文摘 | Kinoshita Y Ueyama T Senba E | 2001 | Neurotmuma2001，18，43： | 1 |
| 7 | A new enzymetic assay for selectively measuring conjugated bilirubin concentration in serum with use of bilinibin oxidase显示文摘 | Kurosaka K Senba S Tsubota H | | 0，，： | 1 |
| 8 | A new enzymatic assay for selectively measuring conjugated bilirubin concentration in serum with use of bilirubin oxidase 显示文摘 | Kurosaka K Senba S Tsubota H | 1998 | Clin Chim Acta1998，269，1： | 1 |
| 9 | Leiomyosarcoma of the maxilla 显示文摘 | Nishi M Mimura T and Senba I | 1987 | J OralMaxillofac Surg1987，45，： | 1 |
| 10 | Enhanced apoptotic and reduced protective response in ehondrocytes following endoplasmic reticulumstress in osteoarthritic cartilage显示文摘 | Takada K Hirose J Senba K | 2011 | J Exp Path2011，92，4： | 1 |
| 11 | Stress-induced c-fos expression in the rat brain:activation mechanism of sympathetic pathway显示文摘 | Senba E Matsunaga K Noguchi K | 1993 | Brain ResBull1993，31，324： | 1 |
| 12 | Hypercalcemia and production of parathyroid hormone-like protein in adult T-cell leukemia-lymphoma显示文摘 | Senba M Kawai K | 1992 | Eur J Haematol1992，48，5： | 1 |
| 13 | Temperature-associated injuries and syndromes显示文摘 | Senba W Ford EG | 1987 | J Trauma1987，，： | 1 |
| 14 | A new enzymatic assay for selectively measuring conjugated bilirubin concetration in serum with use of bilirubin oxidase显示文摘 | Kurosaka K Senba S Tsubota H | 1998 | Clin Chim Acta1998，269，： | 1 |
| 15 | Emotional stress activates MAP kinase in the rat heart显示文摘 | Ueyama T Aki T Senba E | 2001 | Life Sci2001，69，16： | 1 |
| 16 | Expression of c-los, heat shock protein 70, neurotrophiins, and cyclooxygenase-2 mRNA in response to focal cerebral isehemia/reperfusion in rats and their modification by magnesium sulfate显示文摘 | Kinoshita Y Ueyama T Senba E | 2001 | J Neurotrauma2001，18，4： | 1 |
| 17 | Expression of c-fos,heat shock protein 70,neurotrophins,and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate显示文摘 | Kinoshita Y Ueyama T Senba E | 2001 | J Neurotrauma2001，18，4： | 1 |
| 18 | Up-regulated phosphory-lation of signal transducer and activator of transcription 3and cyclic AMP-responsive element binding protein by pe-ripheral inflammation in primary afferent neurons possiblythrough oncostatin M receptor 显示文摘 | Tamura S Morikawa Y Senba E | 2005 | Neuroscience2005，133，3： | 1 |
| 19 | Tumor growth suppression by a'mous/human ahimteric anti-CEA antibody and lymphokine-activated killer cells in vitro and in SCID mouse xenograft model显示文摘 | Senba T Kurki M Arakawa F | 1998 | Anticancer Res1998，18，1： | 1 |
| 20 | The immunosuppressant FK506 activates capsaicin-and bradykinin-sensitive DRG neurons and cutaneous C-fibers显示文摘 | Senba E Katanosaka K Yajima H | 2004 | Neurosci Res2004，50，： | 1 |
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