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| 1 | Pharmacological approach to acute pancreatitis显示文摘The aim of the present review is to summarize the current knowledge regarding pharmacological prevention and treatment of acute pancreatitis (AP) based on experimental animal models and clinical trials. Somatostatin (SS) and octreotide inhibit the exocrine production of pancreatic enzymes and may be useful as prophylaxis against Post Endoscopic retrograde cholangiopancreatography Pancreatitis (PEP). The protease inhibitor Gabexate mesilate (GM) is used routinely as treatment to AP in some countries, but randomized clinical trials and a meta-analysis do not support this practice. Nitroglycerin (NGL) is a nitrogen oxide (NO) donor, which relaxes the sphincter of Oddi. Studies show conflicting results when applied prior to ERCP and a large multicenter randomized study is warranted. Steroids administered as prophylaxis against PEP has been validated without effect in several randomized trials. The non-steroidal anti-inflammatory drugs (NSAID) indomethacin and diclofenac have in randomized studies showed potential as prophylaxis against PEP. Interleukin 10 (IL-10) is a cytokine with anti-inflammatory properties but two trials testing IL-10 as prophylaxis to PEP have returned conflicting results. Antibodies against tumor necrosis factor-alpha (TNF-α) have a potential as rescue therapy but no clinical trials are currently being conducted. The antibiotics beta- lactams and quinolones reduce mortality when necrosis is present in pancreas and may also reduce incidence of infected necrosis. Evidence based pharmacological treatment of AP is limited and studies on the effect of potent anti-inflammatory drugs are warranted. | Ulrich Christian Bang Synne Semb Camilla Nφjgaard Flemming Bendtsen | 2008 | World Journal of Gastroenterology2008，14，19： | 10 |
| 2 | 中国的酸化问题——一项基于重庆—广州森林监测点研究结果的评估显示文摘中国经济的快速增长一直伴随着污染的加剧。本文在现场观测和文献研究的基础上讨论了酸性降水及其先兆的范围和影响。目前酸性降水的主要原因是二氧化硫的排放,但氮氧化物的排放也在增加。中国污染最严重地区的硫化合物沉降比东欧和中欧经受严重污染的地区要高。中国南部很多地区的土壤和土壤水看来已经被酸化。这些地区的污染已经影响了森林和其他植物的生命力,特别是在位于和靠近城市地区的地方。地表水的酸化似乎在近期不会成为主要的区域性问题,但一些地区的河流,目前虽仅接受少量的酸沉降,却对酸化显得较敏感。 | Hans M. Seip Per Aagaard Valter Angell Odd Eilertsen ThorjφrnLarssen Espen Lydersen Jan Mulder Ivar P. Muniz Arne Semb 汤大钢 Rolf D. Vogt 肖劲松 赵大为 孔国辉 岳欣 | 1999 | AMBIO-人类环境杂志1999，28，6： | 5 |
| 3 | Persistent severe hypomagnesemia caused by proton pump inhibitor resolved after laparoscopic fundoplication显示文摘Magnesium deficiency can cause a variety of symptoms, including potentially life-threatening complications such as seizures, cardiac arrhythmias and secondary electrolyte disturbances. Hypomagnesemia can be a serious adverse effect to proton pump inhibitor(PPI) therapy, which is worrying due to the widespread use of PPIs. Current evidence suggest that the mechanism of PPI induced hypomagnesemia is impaired intestinal magnesium absorption. In this report, we present the case of a long-term PPI user with persistent hypomagnesemia with severe symptoms at presentation. He was unable to stop PPI treatment because of severe reflux symptoms, and was dependent on weekly intravenous magnesium infusions, until his magnesium levels finally normalized without the need for supplementation after a successful laparoscopic fundoplication. | Synne Semb Frederik Helgstrand Flemming Hjorne Peter Bytzer | 2017 | World Journal of Gastroenterology2017，23，37： | 2 |
| 4 | 挪威Storgama小型源头集水区积雪操控实验:对无机氮淋溶的影响显示文摘我们对挪威南部山区石南荒地的小型源头集水区冬令时期土壤温度机制进行了操控实验,以研究土壤温度对径流中无机氮浓度和通量的可能影响。实验包括两个集水区土壤的隔热处理,以使土壤在整个冬季保持零上温度;另两个集水区的去除积雪处理,以促使土壤冻结。冬季土壤温度升高增加了春季径流中铵氮(NH_4)和硝酸盐(NO_3)的浓度和通量。相反,去除积雪覆盖,土壤显著冻结,则对无机氮浓度和通量没有系统的影响。我们的实验结果表明,暖冬较高的土壤温度或者较厚的积雪覆盖意味着这一地区无机氮淋溶的风险更大,而雪盖减少导致的土壤冻结事件,造成的无机氮淋溶增加的风险则不大。 | Φyvind Kaste Kari Austnes Live Semb Vestgarden Richard F.Wright 陶书田 | 2008 | AMBIO-人类环境杂志2008，37，1： | 2 |
| 5 | 挪威Storgama小型源头集水区积雪操控实验:对总有机碳和总有机氮淋溶的影响显示文摘预期未来气候变化将引起冬季温度升高,这可能导致北温带较低和中等高度地区的雪积累降低。土壤温度和水状况的变化结果会影响总有机碳(TOC)、总有机氮(TON)的淋溶。本研究在挪威南部的山地荒野区对小型源头集水区的积雪覆盖进行操控实验,以此来量化对径流中TOC和TON浓度和通量的影响。操控实验包括除雪处理(以促进土壤冻结)和隔离处理(以阻止土壤冻结)。除雪处理导致TOC和TON浓度升高,但通量减少。隔离引起TOC浓度和通量少量降低。研究结果表明,积雪深度变化,因而土壤温度也发生变化,对所研究的山地荒野区的TOC和TON淋溶不会有严重影响。 | Kari Austnes Φyvind Kaste Live Semb Vestgarden Jan Mulder 张秋英 | 2008 | AMBIO-人类环境杂志2008，37，1： | 2 |
| 6 | Pharmacological approach to acute pancreatit 显示文摘 | Bang UC Semb S Nojgaard C et aL | 2008 | World J Gastroenterol2008，14，19： | 1 |
| 7 | Pharmacological approach to acute pancreat it显示文摘 | BANG UC SEMB S NOJGAARD C | 2008 | World J Gastroenterol2008，14，19： | 1 |
| 8 | Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orth- odontic treatment 显示文摘 | Bergland O Semb G Abyholm FE | 1986 | Cleft Palate J1986，23，3： | 1 |
| 9 | Elimination of the residual alve- olar cleft by secondary bone grafting and subsequent orthodontic treatment 显示文摘 | Bergland O Semb G Abyholm FE | 1986 | The Cleft Palate Journal1986，23，3： | 1 |
| 10 | Lipoprotein lipase in guinea pig tissues显示文摘 | SEMB H OLIVERCRONA T | 1986 | Biochim Biophys Acta1986，878，： | 1 |
| 11 | The tumor-suppressor function of E-cadherin显示文摘 | Semb H Christofori G | 1998 | Am J Genet1998，63，6： | 1 |
| 12 | The role ofthe cell-cadhesion molecule E-cadherin as a tumour-suppressor gene 显示文摘 | Semb H | 1999 | Trends Biochem Sci1999，24，1： | 1 |
| 13 | Acid deposition and its effects in China: an overview显示文摘 | Thorj?rn Larssen Hans Martin Seip Arne Semb Jan Mulder Ivar P. Muniz Rolf D. Vogt Espen Lydersen Valter Angell Tang Dagang Odd Eilertsen | 1999 | Environmental Science and Policy1999，，1： | 1 |
| 14 | Elimination of the residual alveolar cleft secondary bone grafting and subsequent orthodontic treatment显示文摘 | Bergland O Semb G Abyholm FE | 1986 | Cleft Palate1986，23，3： | 1 |
| 15 | Two different mechanisms are involved in nutritional regulation of lipoprotein lipase in guinea pig adipose tissue显示文摘 | SEMB H OLIVERCRONA T | 1989 | Biochem J1989，262，： | 1 |
| 16 | Raised serum levels of soluble CD40 L in patients with familial hypercholesterolemia: downregulatory effects of statin therapy显示文摘 | Semb AG Van Wissen S Ueland T | 2003 | J Am Coll Cardiol2003，41，2： | 1 |
| 17 | The role of the cell-adhesion molecule E-cadherin as a tumour-suppres- sor gene显示文摘 | Gerhard Christofori Henrik Semb | 1999 | Trends Biochem Sci1999，24，2： | 1 |
| 18 | Multiple effects of tumor necrosis factor on lipoprotein lipase in vivo显示文摘 | Semb H Peterson J Tavernier J | 1987 | Biol Chem1987，262，： | 1 |
| 19 | Acid deposition and its effects in China: an overview显示文摘 | LARSSEN T SEIP H SEMB A | 1999 | Environmental Science & Policy1999，2，1： | 1 |
| 20 | The role of the cell-adhesion molecule E-cadherin as a tumour-suppres-sor gene显示文摘 | Christofori G Semb H | 1999 | Trends Biochem Sci1999，24，2： | 1 |
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