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| 1 | Present and future of metastatic colorectal cancer treatment: A review of new candidate targets显示文摘In the last two decades, great efforts have been made in the treatment of metastatic colorectal cancer(m CRC) due to the approval of new target agents for cytotoxic drugs. Unfortunately, a large percentage of patients present with metastasis at the time of diagnosis or relapse after a few months. The complex molecular heterogeneity of this disease is not completely understood; to date, there is a lack of predictive biomarkers that can be used to select subsets of patients who may respond to target drugs. Only the RAS-mutation status is used to predict resistance to anti-epidermal growth factor receptor agents in patients with m CRC. In this review, we describe approved targeted therapies for the management of metastatic m CRC and discuss new candidate targets on the horizon. | Giulia Martini Teresa Troiani Claudia Cardone Pietropaolo Vitiello Vincenzo Sforza Davide Ciardiello Stefania Napolitano Carminia Maria Della Corte Floriana Morgillo Antonio Raucci Antonio Cuomo Francesco Selvaggi Fortunato Ciardiello Erika Martinelli | 2017 | World Journal of Gastroenterology2017，23，26： | 7 |
| 2 | Liver transplantation for severe hepatic trauma:Experience from a single center显示文摘Liver transplantation has been reported in the literature as an extreme intervention in cases of severe and complicated hepatic trauma.The main indications for liver transplant in such cases were uncontrollable bleeding and postoperative hepatic insufficiency.We here describe four cases of orthotopic liver transplantation after penetrating or blunt liver trauma.The indications were liver failure,extended liver necrosis,liver gangrene and multiple episodes of gastrointestinal bleeding related to portal hypertension,respectively.One patient died due to postoperative cerebral edema.The other three patients recovered well and remain on immunosuppression.Liver transplantation should be considered as a saving procedure in severe hepatic trauma,when all other treatment modalities fail. | Spiros G Delis Andreas Bakoyiannis Gennaro Selvaggi Debbie Weppler David Levi Andreas G Tzakis | 2009 | World Journal of Gastroenterology2009，15，13： | 3 |
| 3 | Novel biomarkers of fibrosis in Crohn's disease显示文摘Fibrosis represents a major challenge in Crohn's disease(CD),and many CD patients will develop fibrotic strictures requiring treatment throughout their lifetime.There is no drug that can reverse intestinal fibrosis,and so endoscopic balloon dilatation and surgery are the only effective treatments.Since patients may need repeated treatments,it is important to obtain the diagnosis at an early stage before strictures become symptomatic with extensive fibrosis.Several markers of fibrosis have been proposed,but most need further validation.Biomarkers can be measured either in biological samples obtained from the serum or bowel of CD patients,or using imaging tools and tests.The ideal tool should be easily obtained,costeffective,and reliable.Even more challenging is fibrosis occurring in ulcerative colitis.Despite the important burden of intestinal fibrosis,including its detrimental effect on outcomes and quality of life in CD patients,it has received less attention than fibrosis occurring in other organs.A common mechanism that acts via a specific signaling pathway could underlie both intestinal fibrosis and cancer.A comprehensive overview of recently introduced biomarkers of fibrosis in CD is presented,along with a discussion of the controversial areas remaining in this field. | Gianluca Pellino Pierlorenzo Pallante Francesco Selvaggi | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，3： | 2 |
| 4 | 前臂桡侧皮瓣是阴茎再造术的标准术式吗?显示文摘背景与目的阴茎再造的目标明确,已有多种皮瓣用于阴茎再造,但没有一种皮瓣是最为理想的再造方法。尽管如此,前臂桡侧皮瓣目前是应用最多、并被广泛认可的标准术式。方法本文回顾分析了287例前臂桡侧皮瓣阴茎再造的结果,是迄今为止患者数最多的报道。手术均由同一医疗小组完成。许多研究数据都已发表在之前的文章中,本综述的主要目的是评价这个“标准术式”可以在多大程度上达到手术预期的目的。结果评价指标包括所需手术次数、并发症、外形美观度、触觉、性敏感度、排尿难易度、供皮区并发症、阴囊外形以及性生活质量等。结论由于缺乏前瞻性随机对照研究,尚不能证明前臂桡侧皮瓣是阴茎再造的最佳方法。但是,这项大样本研究证明,前臂桡侧皮瓣阴茎再造术是一种可靠的再造方法,可以形成外观接近正常的阴茎和阴囊,术后患者可直立排尿,多数患者性生活满意。该手术多数分Ⅱ期完成。该技术的主要缺点包括早期尿道瘘发生率较高,前臂供皮区遗留瘢痕,以及可能并发慢性泌尿系统并发症。尽管缺乏足够的证据,但是笔者认为,如果想要获得更好的手术效果,必须加强整形再造外科医师与泌尿外科医师之间的多学科间紧密合作。 | Stan Monstrey Piet Hoebeke Gennaro Selvaggi Peter Ceulemans Koen Van Landuyt Phillip Blondeel Moustapha Hamdi Nathalie Roche Steven Weyers Griet De Cuypere 姚尧 陶凯 魏峰 高景恒 张晨 | 2012 | 中国美容整形外科杂志2012，23，5： | 2 |
| 5 | Routine use of auxiliary partial orthotopic liver transplantation for children with fulminant hepatic failure:Preliminary report显示文摘 | Kato T Selvaggi G Levi D | 2006 | Transplant Proc2006，38，10： | 1 |
| 6 | Management of bone metastases in cancer: A review 显示文摘 | Selvaggi G Scagliotti GV | 2005 | Crit Rev Oncol Hematol2005，56，3： | 1 |
| 7 | Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer 显示文摘 | Selvaggi G Novello S Torri V | 2004 | Ann Oncol2004，15，1： | 1 |
| 8 | Intestinal and multivisceral transplantation in children 显示文摘 | Kato T Tzakis AG Selvaggi G | 2006 | Ann Surg2006，243，6： | 1 |
| 9 | Detection ofend- omelrial adenoearcinoma with the ThinPrep P ap test显示文摘 | Guidos B J Selvaggi SM | 2000 | Diagn Cytopathol2000，23，： | 1 |
| 10 | A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome:results of the STAR trial显示文摘 | Chapple CR Martinez-Garcia R Selvaggi L | 2005 | Eur Urol2005，48，3： | 1 |
| 11 | Use of the abdominal rectus fascia as a nonvascularized allograft for abdominal wall closure after liver, intestinal, and multivisceral transplantation 显示文摘 | Gondolesi G Selvaggi G Tzakis A | 2009 | Transplantation2009，87，12： | 1 |
| 12 | Utility of cell blocks in the diagnosis of thyroid aspirates显示文摘 | Sanchez N Selvaggi SM | | 0，，02： | 1 |
| 13 | Is there a link be- tween insulin resistance and inflammatory activation in preeclampsia?显示文摘 | Scioscia M Greco P Selvaggi LE | 2009 | Med Hypotheses2009，73，5： | 1 |
| 14 | Late results of burn wound scar after cerium nitrate-silver sulfadiazine and compressive therapu: scanning eletronmicroscopy evaluation of keloid scar显示文摘 | Selvaggi G Boeckx W De WulfM | 2007 | Plast Reconstr Surg2007，119，6： | 1 |
| 15 | Small bowel transplantation: technical advances/updates 显示文摘 | Selvaggi G Tzakis AG | 2009 | Curr Opin Organ Transplant2009，14，3： | 1 |
| 16 | Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii显示文摘 | Loizzi V Cormio G Resta L Fattizzi N Vieino M Selvaggi L | 2005 | Gynecol Oncol2005，97，： | 1 |
| 17 | Neoadjuvant chemotherapy in cervical cancer: a 67 patients experience 显示文摘 | Selvaggi L Loizzi V Gilio AR | 2006 | Int J Gynecol Oncol2006，16，7： | 1 |
| 18 | Neoadjuvant chemotherapy in cervical cancer:A 67 patients experience显示文摘 | Selvaggi I Loizzi V DI Gilio A R | 2006 | Int J Gynecol Cancer2006，16，2： | 1 |
| 19 | Routine use of auxiliary partial orthotopic liver transplantation for children with fulminant hepatic failure: Preliminary report显示文摘 | Kato T Selvaggi G Levi D | 2006 | Transplant Proc2006，38，10： | 1 |
| 20 | Gluteal augmentation surgery:indications and surgical management显示文摘 | Harrison D Selvaggi G | 2007 | Plast Reconstr Aesth Surg2007，60，8： | 1 |
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