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| 1 | Antioxidative effect of melatonin, ascorbic acid and N-acetylcysteine on caerulein-induced pancreatitis and associated liver injury in rats显示文摘瞄准:在老鼠在导致 caerulein 的胰腺炎和联系肝损伤上处于导致胰腺炎的肝的损坏和象 melatonin,抗坏血酸和 N 乙酰半胱氨酸那样的抗氧化剂代理人的效果调查氧化损害的角色。方法:38 只女 Wistar 老鼠被使用。尖锐胰腺炎(AP ) 被 caerulein 的二 i.p 注射在 2-h 间隔导致(在 100 microg/kg b.wt 的全部的剂量) 。另外的二个组收到了另外的 melatonin (20 mg/kg b.wt ) 或包含 L (+) 维生素酸(14.3 mg/kb.wt.) 和 N 乙酰半胱氨酸(181 mg/kg b.wt ) 的抗氧化剂混合物立即在 caerulein 的每注射前的 i.p。老鼠被斩首杀头 12 h 在 caerulein 的最后注射以后牺牲。胰腺、肝的氧化压力标记被变化在在织物抗氧化剂酶层次,过氧化氢酶(猫) 和谷胱甘肽过氧化物酶(GPx ) 作为 malondialdehyde (MDA ) 和变化测量的类脂化合物过氧化物的数量评估。组织病理学说的检查用获得系统被执行。结果:肝的房间退化,细胞内部的空泡形成,脉管的拥挤,正弦曲线膨胀和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.001 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。ciner 房间退化,胰腺的浮肿,细胞内部的空泡形成和炎性浸润的度显示出在 caerulein 和 caerulein + melatonin 之间的有效差量(P = 0.004 ) ,并且 careulein 和 caerulein + L (+) 维生素酸 +N 乙酰半胱氨酸组(P = 0.002 ) 。 导致Caerulein 胰腺并且肝损坏伴有织物 MDA 层次的重要增加( P = 0.01 , P = 0.003 ,分别地)而在猫的重要减少( P = 0.002 , P = 0.003 ,分别地)并且 GPx 活动( P = 0.002 , P = 0.03 ,分别地)。Melatonin 和 L (+) 维生素 acid+N 乙酰半胱氨酸管理显著地减少了在胰的 MDA 层次(P=0.03, P=0.002,分别地) 并且肝(P = 0.007, P = 0.01,分别地) 。这些代理人的管理增加了胰腺、肝的猫和 GPx 活动。Melatonin 显著地增加了胰腺、肝的猫(P = 0.002, P = 0.001,分别地) 并且 GPx 活动(P = 0.002, P = 0.001 ) 。另外, L (+) 维生素酸 +N 乙酰半胱氨酸显著地增加了胰腺的 GPx (P = 0.002 ) 并且肝的猫和 GPx 活动(P = 0.001, P = 0.007,分别地).CONCLUSION:氧化损害不仅在 AP 的致病而且处于导致胰腺炎的肝的损坏起一个重要作用。抗氧化剂代理人象 melatonin 和抗坏血酸 +N 乙酰半胱氨酸那样,能够限制经由恢复织物抗氧化剂酶活动在 AP 期间生产的胰腺、肝的损坏。 | Mukaddes E■refoglu Mehmet Gül Burhan Ate■ Kadir Batoglu Mukadder Ay■e Selimoglu | 2006 | World Journal of Gastroenterology2006，12，2： | 29 |
| 2 | Protective effect of low dose of melatonin against cholestatic oxidative stress after common bile duct ligation in rats显示文摘AIM: To investigate the role of oxidative injury and the effect of exogenous melatonin administration on liver damage induced by bile duct ligation (BDL), and second,to evaluate the role of nitric oxide (NO), a free oxygen radical, in oxidative injury.METHODS: Thirty-two Sprague-Dawley rats were assigned to four groups: sham operation (SO), BDL, BDL+melatonin,and BDL+vehicle. Cholestasis was achieved by double ligature of the common bile duct. Melatonin was injected intraperitoneally 500 μg/(kg.d) for 8 d. Hepatic oxidative stress markers were evaluated by changes in the amount of lipid peroxides, measured as malondialdehyde (MDA),and reduced GSH. Total nitrite (NOx) concentrations were determined in hepatic homogenates. Histopathological examination was performed using a histological scoring system.RESULTS: The histopathological changes including portal inflammation, necrosis, apoptosis, focal inflammation and fibrosis were severe in the BDL and BDL+vehicle groups. There were numerous large areas of coagulation necrosis. Histological Activity Index scores of these groups were significantly higher than that of the SO group. Treatment with melatonin reduced these alterations significantly. The degree of necro-infiammation and fibrosis showed significant difference between the BDL and BDL+melatonin groups. BDL was accompanied by a significant increase in MDA and NOx, and a significant decrease in GSH levels. Mean±SE values of MDA, GSH and NOx levels of SO group were 147.47±6.69, 0.88±0.33 μmol/g and 180.70±6.58 nm/g, respectively. The values of BDL group were 200.14±21.30, 0.65±0.02 μmol/g, and 400.46±48.89 nm/g, respectively, whereas the values of BDL+melatonin group were 115.93±6.8, 0.74±0.02 μmol/g,and 290.38±32.32 nm/g, respectively. Melatonin treatment was associated with a significant recovery of MDA, GSH and NOx levels.CONCLUSION: We have concluded that oxidative stress is associated with the pathogenesis of cholestatic liver damage and NO contributes to oxidative damage. Melatonin,even at low dose, is an efficient agent in reducing negative parameters of cholestasis. | Mukaddes Esrefoglu Mehmet Gül Memet Hanifi Emre Alaattin Polat Mukadder Ayse Selimoglu | 2005 | World Journal of Gastroenterology2005，11，13： | 6 |
| 3 | The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome显示文摘 | Selimoglu H Duran C Kiyici S | 2010 | J Endocrinol Invest2010，33，4： | 1 |
| 4 | Epidemiology of hepatitis B virus infection among family members of children with chronic hepatitis B virus infection in eastern Turkey显示文摘 | Ertekin V Selimoglu MA | 2003 | Eur J Gastroenterol Hepatol2003，15，13： | 1 |
| 5 | Management of neglected periorbital squamous cell carcinoma requiring orbital exenteration显示文摘 | KARABEKMEZ F E SELIMOGLU M N DUYMAZ A | 2014 | J Craniofac Surg2014，25，： | 1 |
| 6 | Seroepidemiology of Helicohacter pylori infection in children living in eastern Turkey显示文摘 | Ayse Selimoglu M Ertekin V Inandi T | 2002 | Pediatr Int2002，44，： | 1 |
| 7 | Does adenotonsillectomy improve growth in children with obstructive adenoton- sillar hypertrophy? 显示文摘 | Setimgolu E Selimoglu MA Orbak Z | 2003 | J Int Med Res2003，31，2： | 1 |
| 8 | Analysis of unilateral complex orbital fractures with a new treat- ment algorithm 显示文摘 | Karamese M Akdag O Selimoglu M N | 2015 | J Plast Surg Hand Surg2015，49，2： | 1 |
| 9 | Cotyledonoid dissecting leiomyoma of the uterus with intravascular growth in postmenopausal woman: a case presentation显示文摘 | Gezginc K Yazici F Selimoglu R Tavli L | 2011 | Int J Clin Oncol2011，16，： | 1 |
| 10 | Low plasma apoliporotein A-I level: new prognostic criterion in childhood cirrhosis?显示文摘 | Selimoglu MA Aydogclu S | 2001 | Turk J Pediatr2001，43，4： | 1 |
| 11 | Long-term results ofthe left anterior descending coronary artery reconstruction with left internal thoracic artery显示文摘 | Ogus TN Basaran M Selimoglu O | 2007 | Ann Thorac Surg2007，83，2： | 1 |
| 12 | An fron- talis sling operation using an autogenous en-bloc, fan- shaped tensor fascia lata graft for blepharoptosis 显示文摘 | Gundeslioglu AO Selimoglu MN Bekerecioglu M | 2013 | J Plast Reconstr Aesthet Surg2013，66，2： | 1 |
| 13 | Eficacy of remote ischaemic preconditioning for spinal cord protection against ischaemic injury:association with heat shock protein expression显示文摘 | Selimoglu O Ugurlucan M Basaran M | | 0，，3： | 1 |
| 14 | An frontalis sling operation using an autogenous en-bloc, fan-shaped tensor fascia lata graft for blepharoptosis 显示文摘 | Gundeslioglu A O Selimoglu M N Bekerecioglu M | 2013 | Journal of Plastic Reconstructive & Aesthetic Surgery2013，66，2： | 1 |
| 15 | The role of fecalcalprotectin and lactoferrin in the diagnosis of necrotizingenterocolitis显示文摘 | Selimoglu MA Temel I Yildirim C | 2012 | Pediatr Crit Care Med2012，13，4： | 1 |
| 16 | Bone mineral density of children with Wilson disease: efficacy of penicillamine and zinc therapy 显示文摘 | Selimoglu MA Ertekin V Doneray H | 2008 | J Clin Gastroenterol2008，42，2： | 1 |
| 17 | Efficacy of remote ischaemic preconditioning for spinal cord protec- tion against ischaemic injury, association with heat shock protein expression 显示文摘 | Selimoglu O Ugurluean M Basaran M | 2008 | Folia Neuropathologica2008，46，3： | 1 |
| 18 | Lipid parameters in childhood cirrhosis and chronic liver disease显示文摘 | Selimoglu MA Aydogdu S Yagci RV | 2002 | Pediatr Int2002，44，4： | 1 |
| 19 | Fecal calprotectinconcentration in celiac disease显示文摘 | Ertekin V Selimoglu MA Turgut A | 2010 | J Clin Gastroenterol2010，44，8： | 1 |
| 20 | The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome显示文摘 | Selimoglu H Duran C Kiyici S | 2010 | J Endocrinol Invest2010，33，4： | 1 |
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