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| 1 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 2 | Hepatocellular carcinoma in Egypt: A single center study over a decade显示文摘AIM: To identify the trend, possible risk factors and any pattern change of hepatocellular carcinoma (HCC) in Egyptover a decade.METHODS: All HCC patients attending Cairo Liver Center between January 1993 and December 2002, were enrolledin the study. Diagnosis of HCC was based on histopath ological examination and/or detection of hepatic focal lesions by two imaging techniques plus α-fetoprotein level above 200 ng/mL. The duration of the study was divided into two periods of 5 years each; period Ⅰ (1993-1997) and period Ⅱ (1998-2002). Trend, demographic features of patients (age, gender, and residence), risk factors (HBsAg,HCV-Ab, schistosomiasis and others) and pattern of the focal lesions were compared between the two periods.Logistic regression model was fitted to calculate the adjusted odds ratios for the potential risk factors. The population attributable risk percentage was calculated to estimate the proportion of HCC attributed to hepatitis B and C viral infections.RESULTS: Over a decade, 1 328 HCC patients out of 22 450 chronic liver disease (CLD) patients were diagnosed with an overall proportion of 5.9%. The annual proportion of HCC showed a significant rising trend from 4.0% in 1993 to 7.2% in 2002 (P = 0.000). A significant increase in male proportion from 82.5% to 87.6% (P = 0.009); M/F from 5:1 to 7:1 and a slight increase of the predominant age group (40-59 years) from 62.6% to 66.8% (P = 0.387)in periods Ⅰ and Ⅱ respectively, reflecting a shift to younger age group. In the bivariate analysis, HCC was significantly higher in rural residents, patients with history of schistosomiasis and/or blood transfusion. Yet, after adjustment, these variables did not have a significant risk for development of HCC. There was a significant decline of HBsAg from 38.6% to 20.5% (P = 0.000), and a slight increase of HCV-Ab from 85.6% to 87.9% in periods Ⅰ and Ⅱ respectively. HBV conferred a higher risk to develop HCC more than HCV in period Ⅰ (OR 1.9 vs 1.6) and period Ⅱ (OR 2.7 vs 2.0), but the relative contribution of HBV for development of HCC declined in period Ⅱ compared to period Ⅰ (PAR% 4.2%, 21.32%). At presentation,diagnostic α-fetoprotein level (≥200 ng/mL) was demonstrated in 15.6% vs28.9% and small HCC (≤3 cm)represented 14.9% vs 22.7% (P = 0.0002) in periods Ⅰ and Ⅱ respectively.CONCLUSION: Over a decade, there was nearly a twofold increase of the proportion of HCC among CLD patients in Egypt with a significant decline of HBV and slight increase of HCV as risk factors. α-Fetoprotein played a limited role in diagnosis of HCC, compared to imaging techniques.Increased detection of small lesions at presentation reflects increased awareness of the condition. | Adbel-Rahman El-Zayadi Hanaa M Badran Eman MF Barakat Mohy El-Deen Attia Sherine Shawky Mostafa K Mohamed Osaima Selim Ahmed Saeid | 2005 | World Journal of Gastroenterology2005，11，33： | 5 |
| 3 | K-means-type algorithm显示文摘 | Selim S Z Ismail M A | 1994 | IEEE Trans Pattern Anal Mach Intell1994，6，1： | 2 |
| 4 | New algorithms for solving the fuzzy clustering problem显示文摘 | Kamel M S Selim Z | 1994 | Pattern Recognition1994，27，3： | 1 |
| 5 | Perioperative Stroke 显示文摘 | Selim M | 2007 | N Engl J Med2007，356，7： | 1 |
| 6 | Diagnosis of cerebral venous thrombosis with echo-planar T2-weighted magnetic resonance imaging 显示文摘 | Selim M Fink J Linfante I | 2002 | Arch Neurol2002，59，6： | 1 |
| 7 | New algorithms for solving the fuzzy clustering problem显示文摘 | Kamel M Selim S Z | 1994 | Pattern Recognition1994，27，3： | 1 |
| 8 | Diagnosis of cerebral venous thrombosis with echoplanar T2-weighted magnetic resonance imaging显示文摘 | Selim M Fink J Linfante l | 2002 | Arch Neurol2002，59，6： | 1 |
| 9 | Hydrate dissociation in sediment 显示文摘 | Selim M S Sloan E D | 1990 | SPE Reservoir Engineering1990，5，2： | 1 |
| 10 | Diagnosis of cerebral venous thrombosis with echoplanar T2 weighted magnetic resonance resonance imaging显示文摘 | Selim M Fink J Linfante I | 2002 | Arch Neurol2002，59，6： | 1 |
| 11 | Predicting atrazine adsorption-desorption in soils:A modified second-order kinetic model显示文摘 | MA L SELIM H M | 1994 | Water Resource Research1994，30，： | 1 |
| 12 | Predicting pesticide transport in mulch-amended soils:A two-compartment model显示文摘 | MA L SELIM H M | 2005 | Soil Science Society of America Journal2005，69，： | 1 |
| 13 | Hormonal and sonographic assessment of ovarian reserve before and after laparoscopic ovarian drilling in polycystic ovary syndrome显示文摘 | KANDIL M SELIM M | | 0，，10： | 1 |
| 14 | Predictors of hemorrhagic transformation after intravenous recombinant tissue plasminogen activator: prognostic value of the initial apparent diffusion coefficient and diffusion-weighted lesion volume 显示文摘 | Selim M Fink JN Kumar S | 2002 | Stroke2002，33，8： | 1 |
| 15 | K-means-type algorithm 显示文摘 | Selim S Z Ismail M A | 1994 | IEEE Trans Pattern Anal Mach Intell1994，6，1： | 1 |
| 16 | Hysteretic behavoir of metolachlor adsorptiondesorption in soils显示文摘 | Zhu H Selim H M | 2000 | Soil Science2000，165，8： | 1 |
| 17 | Experimental and theoretical investigation of methane-gas-hydrate dissociation in porous media 显示文摘 | Yousif M H Ahass H H Selim M S | 1991 | SPE Reservoir Eng1991，6，4： | 1 |
| 18 | Confocal microscopy study of nerves and blood vessels in untreated and treated port wine stains:preliminary observations显示文摘 | Selim M M Kelly K M Nelson J S | 2004 | Dermatol Surg2004，30，： | 1 |
| 19 | Safety and tolerabil- ity of deferoxamine mesylate in patients with acute intracere- bral hemorrhage显示文摘 | Selim M Yeatts S Goldstein JN etal | 2011 | Stroke2011，4201，： | 1 |
| 20 | Experimental and simulated transport of phosphorus through sandy soils显示文摘 | Mansell R S Selim H M Kanchanasut | 1977 | Water Resource Res1977，13，2： | 1 |
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