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| 1 | Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes显示文摘AIM: To investigate the influence of proton pump inhibitors(PPIs) exposure on the diagnosis of Helicobacter pylori(H. pylori) gastritis and intestinal metaplasia.METHODS: Chronic PPI use is associated with masking of H. pylori infection. Patients with H. pylori infection are predisposed to gastric and duodenal ulcers, and long-term infection with this organism has been associated with gastric mucosal atrophy and serious long-term complications, such as gastric lymphoma and adenocarcinoma. Three hundred patients diagnosed with gastritis between January 2008 and April 2010 were included in our study. The computerized medical database of these patients was reviewed retrospectively in order to assess whether the type of gastritis diagnosed(H. pylori vs non-H. pylori gastritis) is influenced by PPI exposure. H. pylori density was graded as low, if corresponding to mild density following the Updated Sydney System, or high, if corresponding to moderate or severe densities in the Updated Sydney System.RESULTS: Patients were equally distributed between males and females with a median age at the time of diagnosis of 50 years old(range: 20-87). The histological types of gastritis were classified as H. pylori gastritis(n = 156, 52%) and non-H. pylori gastritis(n = 144, 48%). All patients with non-H. pylori gastritis had inactive chronic gastritis. Patients with no previous PPI exposure were more likely to be diagnosed with H. pylori gastritis than those with previous PPI exposure(71% vs 34.2%, P < 0.001). Intestinal metaplasiawas more likely to be detected in the latter patients(1.4% vs 6.5%, P = 0.023). Multivariate analysis has also demonstrated that in the presence of previous PPI exposure(OR = 0.217, 95%CI: 0.123-0.385), GERD(OR = 0.317, 95%CI: 0.132-0.763, P = 0.01), alcohol intake(OR = 0.396, 95%CI: 0.195-0.804, P = 0.01), the detection of H. pylori was less likely. Chronic use of PPIs may mask H. pylori infections promoting the diagnosis of non-H. pylori gastritis and leads to a significant drop in H. pylori densities and to an increased risk of intestinal metaplasia.CONCLUSION: The use of PPIs masks H. pylori infection, promotes the diagnosis of non-H. pylori inactive chronic gastritis diagnosis, and increases the incidence of intestinal metaplasia. | Soumana C Nasser Mahmoud Slim Jeanette G Nassif Selim M Nasser | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 2 | Alvarado, Eskelinen, Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis scores for diagnosis of acute appendicitis显示文摘AIM:To assess the reliability and practical applicability of the widely used Alvarado,Eskelinen,Ohhmann and Raja Isteri Pengiran Anak Saleha Appendicitis(RIPASA)scoring systems in patients with suspected acute appendicitis.METHODS:Patients admitted to our tertiary center due to suspected acute appendicitis constituted the study group.Patients were divided into two groups.appendicitis group(Group A)consisted of patients who underwent appendectomy and were histopathologically diagnosed with acute appendicitis,and non-appendicitis group(Group N-A)consisted of patients who underwent negative appendectomy and were diagnosed with pathologies other than appendicitis and patients that were followed non-operatively.The operative findings for the patients,the additional analyses from follow up of the patients and the results of those analyses were recorded using the follow-up forms.RESULTS:One hundred and thirteen patients with suspected acute appendicitis were included in the study.Of the 113 patients(62 males,51 females),the mean age was 30.2±10.1(range 18-67)years.Of the 113patients,94 patients underwent surgery,while the rest were followed non-operatively.Of the 94 patients,77patients were histopathologically diagnosed with acute appendicitis.Our study showed a sensitivity level of81%for the Alvarado system when a cut-off value of 6.5was used,a sensitivity level of 83.1%for the Ohmann system when a cut-off value of 13.75 was used,a sensitivity level of 80.5%for the Eskelinen system when a cut-off value of 63.72 was used,and a sensitivity level of 83.1%for the RIPASA system when a cut-off value of 10.25 was used.CONCLUSION:The Ohmann and RIPASA scoring systems had the highest specificity for the diagnosis of acute appendicitis. | Hasan Erdem Süleyman etinkünar Koray Das Enver Reyhan Cumhur Deger Mehmet Aziret Hilmi Bozkurt Seluk Uzun Selim Szen Oktay rkrücü | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 3 | The potentialofusing vegetable oil as fuel for diesel engines 显示文摘 | Recep A Selim C | 2001 | Energy Convers Manage2001，42，5： | 1 |
| 4 | Increased levels of vascular endothelial growth factor in the aqueous hu- mor of patients with diabetic retinopathy显示文摘 | Selim KM Sahan D Muhittin T Osman C Mustafa O | 2010 | Indian J Ophthal- mol2010，58，5： | 1 |
| 5 | A Fuzzy Multi--ob- jective Covering--based Vehicle Location Model for Emergency Services显示文摘 | Araz C Selim H Ozkarahan I | 2007 | Computers and Operations Research2007，34，3： | 1 |
| 6 | Cardiovascular consequences of sleep apnea显示文摘 | Selim B Won C Yaggi HK | 2010 | Clini Chest Meal2010，31，2： | 1 |
| 7 | Modeling the Transport and Retention of Cadmium in Soils;Muhire-action and Multicomponent Approaches显示文摘 | Selim H M Buchter B Hinz C | 1992 | Soil Sci1992，56，2： | 1 |
| 8 | Transport of Zinc and Cadmium in Soils:Experimental Evidence and Modeling Approaches显示文摘 | Hinz C Selim H M | 1994 | Soil Sci1994，58，2： | 1 |
| 9 | Platelet function assays in strokemanagement: more study is needed显示文摘 | SELIM M H MOLINA C A | 2010 | Stroke2010，41，10： | 1 |
| 10 | Retention and release of metals by soils-evaluation of several models显示文摘 | AMACHER M C KOTUBY-AMACHER J SELIM H M | 1986 | Geoderma1986，38，： | 1 |
| 11 | Collaborative productiontistribution planning in supply chain: A fuzzy goal programming approach显示文摘 | SELIM H ARAZ C OZKARAHAN I | 2008 | Transportation Research(Part E Logistics & Transportation Review)2008，44，3： | 1 |
| 12 | Thermal isolation and mechanical properties of fibre reinforced mud bricks as wall materials显示文摘 | Hanifi Binici a Orhan Aksogan b Mehmet Nuri Bodur c Erhan Akca d Selim Kaput | 2007 | Construction and Building Materials2007，21，1： | 1 |
| 13 | Modeling the transport and retention of cadmium in soils: Multireaction and multicomponent approaches显示文摘 | SELIM H M BUCHTER B HINZ C | 1992 | Soil Sci SoeAm J1992，56，： | 1 |
| 14 | Platelet function assays in stroke management:more study is needed显示文摘 | SELIM M H MOLINA C A | 2010 | Stroke2010，41，10： | 1 |
| 15 | Kinetics of chromium (Ⅵ) and cadmium retention in soils: a nonlinear multireaction model显示文摘 | AMACHER M C SELIM H M ISKANDAR I K | 1988 | Soil Sci SocAm J1988，52，： | 1 |
| 16 | A detailed kinetic study of ammonia oxidation显示文摘 | LINDESTEDE R P LOCHWOOD F C SELIM M A | 1995 | Combustion Science and Technology1995，108，： | 1 |
| 17 | Reduced cytotoxicity of insulin-immobilized CdS quantum dots using PEG as a spacer显示文摘 | SELIM K K X1NG Z C CHOI M J | 2011 | Nanoscale Res Lett2011，6，1： | 1 |
| 18 | A fuzzy multi-objective covering-based vehicle location model for emergency services显示文摘 | Araz C Selim H Ozkarahan I | 2007 | Computers & Operations Research2007，34，3： | 1 |
| 19 | Adsorption and transport of uranium (VI) in subsurface media 显示文摘 | Barnett M O Jardine P M Brooks S C Selim H M | 2000 | Soil Science Society of America Journal2000，64，3： | 1 |
| 20 | A Fuzzy Multi- objective Covering-based Vehicle Location Model for Emergency Services 显示文摘 | ARAZ C SELIM H OZKARAHAN I | 2007 | Computers & Operations Research2007，34，3： | 1 |
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