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| 1 | Protective links between vitamin D,inflammatory boweldisease and colon cancer显示文摘Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer. | Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik | 2016 | World Journal of Gastroenterology2016，22，3： | 15 |
| 2 | Trust negotiation on the Web显示文摘 | WINSLETT M YU T SEAMONS K | 2002 | IEEE Internet Computing2002，6，6： | 1 |
| 3 | Influ-ence of intraoperative capsule rupture on outcomes in stage I epi-thelial ovarian cancer 显示文摘 | Bakkum - Gamez JN Richardson DL Seamon LG | 2009 | Obstet Gynecol2009，113，1： | 1 |
| 4 | A prospective valida tion of a current practice:the detection of extremity vascular inju ry with CT angiography显示文摘 | Seamon MJ Smoger D Torres DM | 2009 | J Trauma2009，67，2： | 1 |
| 5 | The NLRP3 inflammasome promotes renal inflammation and cont- ri-butes to CKD显示文摘 | VILAYSANE A CHUN J SEAMONE M E | 2010 | Journal of the American Society of Neph- rology2010，21，10： | 1 |
| 6 | Increased dietary vitaminD suppresses MAPK signaling, colitis, and colon cancer 显示文摘 | Meeker S Seamons A Paik J | 2014 | Cancer Res2014，74，16： | 1 |
| 7 | A detailed analysis of the learning curve:robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial cancer显示文摘 | Seamon LG Fowler JM Richardson DL | 2009 | Gynecol Oncol2009，114，2： | 1 |
| 8 | Protecting Privacy During on Line Trust Negotiation 显示文摘 | Seamons K E Winslett M Yu T | 2003 | Lecture Notes in Computer Science2003，2482，1： | 1 |
| 9 | Sexual function after intracavitary vaginal brachytherapy for early-stage endometrial carcinoma 显示文摘 | Quick AM Seamon LG Abdel-Rasoul M | 2012 | Int J Gynecol Cancer2012，22，4： | 1 |
| 10 | Trust Negotiation on the Web显示文摘 | Winslett M Yu T Seamons K | 2002 | IEEE Internet Computing2002，6，6： | 1 |
| 11 | A ten-year retrospective review: does pyloric exclusion improve clinical outcome after penetrating duodenal and combined pancreaticoduodenal injuries 显示文摘 | Seamon MJ Pieri PG Fisher CA | 2007 | J Trauma2007，62，4： | 1 |
| 12 | A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells显示文摘 | Zhang Z Knobloch TJ Seamon LG | 2011 | Gynecol 0ncol2011，123，2： | 1 |
| 13 | Reclassification of leiomyosarcoma as an extragastrointestinal stromal tumor of the gynecologic tract显示文摘 | Molina I Seamon LG Copeland LJ | 2009 | Int J Gynecol Pathol2009，28，5： | 1 |
| 14 | Supporting Structured Credentials and Sensitive Policies Through Interoperable Strat-egies for Automated Trust Negotiation显示文摘 | Yu T Winslett M Seamons K E | 2003 | ACM Transactions on Information and System Security(TISSEC)2003，6，1： | 1 |
| 15 | Pancreatic injury in damage control laparotomies:Is pancreatic resection safe during the initial laparotomy显示文摘 | Seamon MJ Kim PK Stawicki SP | 2009 | Injury2009，40，1： | 1 |
| 16 | A detailed analysis of the learning curve:robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial cancer 显示文摘 | Seamon LG Fowler JM Richardson DL | 2009 | Gynecol Oncol2009，114，2： | 1 |
| 17 | The effects of intraoperative hypothermia on surgical site infection:an analysis of524trauma laparotomies显示文摘 | Seamon MJ Wobb J Gaughan JP | 2012 | Ann Surq2012，255，4： | 1 |
| 18 | The Mere Expo-sure Effect Is Based on Implicit Memory:Effects of StimulusType,Encoding Conditions,and Number of Exposures onRecognition and Affect Judgments显示文摘 | Seamon J Williams P Crowley M etc | 1995 | Journal of Experi-mental Psychology:Learning Memory and Cognition1995，21，3： | 1 |
| 19 | A detailed analysis of the learning curve:robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial cancer显示文摘 | SEAMON L G FOWLER J M RICHARDSON D L | 2009 | Gynecol Oncol2009，114，2： | 1 |
| 20 | The effects of intra- operative hypothermia on surgical site infection:an analysis of 524 trauma laparotomies 显示文摘 | Seamon M J Wobb J Gaughan JP | 2012 | Annals of surgery2012，255，4： | 1 |
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