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| 1 | Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1显示文摘Periodontal disease is associated with chronic oxidative stress and inflammation. Caffeic acid phenethyl ester(CAPE), which is a potent inducer of heme oxygenase 1(HO1), is a central active component of propolis, and the application of propolis improves periodontal status in diabetic patients. Here, primary murine macrophages were exposed to CAPE. Target gene expression was assessed by whole-genome microarray, RT-PCR and Western blotting. The antioxidative and anti-inflammatory activities of CAPE were examined by exposure of the cells to hydrogen peroxide, saliva and periodontal pathogens. The involvement of HO1 was investigated with the HO1 inhibitor tin protoporphyrin(SnPP) and knockout mice for Nrf2, which is a transcription factor for detoxifying enzymes. CAPE increased HO1 and other heat shock proteins in murine macrophages. A p38 MAPK inhibitor and Nrf2 knockout attenuated CAPE-induced HO1 expression in macrophages. CAPE exerted strong antioxidative activity. Additionally, CAPE reduced the inflammatory response to saliva and periodontal pathogens. Blocking HO1 decreased the antioxidative activity and attenuated the anti-inflammatory activity of CAPE. In conclusion, CAPE exerted its antioxidative effects through the Nrf2-mediated HO1 pathway and its anti-inflammatory effects through NF-κB inhibition. However, preclinical models evaluating the use of CAPE in periodontal inflammation are necessary in future studies. | Alexandra St?hli Ceeneena Ubaidha Maheen Franz Josef Strauss Sigrun Eick Anton Sculean Reinhard Gruber | 2019 | International Journal of Oral Science2019，11，1： | 4 |
| 2 | Preparation,characterization and biological properties of a novel bone block composed of platelet rich fibrin and a deproteinized bovine bone mineral显示文摘Alveolar bone defects caused by tooth loss often lead to challenges in implant dentistry,with a need for development of optimal bone biomaterials to predictably rebuild these tissues.To address this problem,we fabricated a novel bone block using platelet-rich fibrin(PRF)and Deproteinized Bovine Bone Mineral(DBBM),and characterized their mechanical and biological properties.The bone block was prepared by mixing DBBM,Liquid-PRF,and Solid-PRF fragments in various combinations as follows:(1)BLOCK-1 made with Solid-PRF fragments+DBBM,(2)BLOCK-2 made with Liquid-PRF+DBBM,(3)BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM.The time for solidification and the degradation properties were subsequently recorded.Scanning electron microscopy(SEM)and tensile tests were carried out to investigate the microstructure and mechanical properties of each block.The bioactivity of the three groups towards osteoblast differentiation was also evaluated by culturing cells with the conditioned medium from each of the three groups including cell proliferation assay,cell migration assay,alkaline phosphatase(ALP)staining,and alizarin red staining(ARS),as well as by real-time PCR for genes encoding runt-related transcription factor 2(RUNX2),ALP,collagen type I alphal(COLIv41)and osteocalcin(OCN).BLOCK-3 made with Solid-PRF fragments+Liquid-PRF+DBBM had by far the fastest solidification period(over a 10-fold increase)as well as the most resistance to degradation.SEM and tensile tests also revealed that the mechanical properties of BLOCK-3 were superior in strength when compared to all other groups and further induced the highest osteoblast migration and osteogenic differentiation confirmed by ALP,ARS and real-time PCR.PRF bone blocks made through the combination of Solid-PRF fragments+Liquid-PRF+DBBM had the greatest mechanical and biological properties when compared to either used alone.Future clinical studies are warranted to further support the clinical application of PRF bone blocks in bone regeneration procedures. | Mengge Feng Yulan Wang Yan Wei Xiaoxin Zhang Leyi Xiao Zijjian Gong Masako Fujioka-Kobayashi Anton Sculean Richard J Miron Scott Froum Yufeng Zhang | 2022 | Fundamental Research2022，2，2： | 3 |
| 3 | Clinical evaluation of an Er:YAG laser combined with scaling and root planing for non-surgical periodontal treatment: a controlled, prospective clinical study显示文摘 | Schwarz F Sculean A Berakdar M | 2003 | J Clin Periodontol2003，30，1： | 1 |
| 4 | Anti-infective therapy with an Er: YAG laser:influenceon peri-implant healing显示文摘 | Sculean A Schwarz F Becker J | 2005 | Expert Rev Med Devices2005，2，3： | 1 |
| 5 | Facts and myths regarding the maxillary midline frenum and its treatment: a systematic review of the literature 显示文摘 | Delli K Livas C Sculean A | 2013 | Quintessence Int2013，44，2： | 1 |
| 6 | Healing of intra-bony defects following treatment with a composite bovine-derived xenograft (Bio-Oss Collagen) in combination with a collagen membrane (Bio-Gide PERIO)显示文摘 | Chiantella GC Windisch P | 2005 | J Clln Periodontol2005，32，7： | 1 |
| 7 | Clinical and histologic evaluation of an enamel natrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans显示文摘 | Windisch P Keglevich T | 2005 | Int J Periodonties Restorative Dent2005，25，2： | 1 |
| 8 | Clinical evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans 显示文摘 | Sculean A Barbe G Chiantella GC | 2002 | J Periodontal2002，73，4： | 1 |
| 9 | Regeneration of periodontal tissues: combinations of barrier membranes and grafting materialsbiological foundation and preclinical evidence: a systematic review显示文摘 | Sculean A Nikolidakis D Schwarz F | 2008 | J Clin Periodontol2008，35，8： | 1 |
| 10 | Periodontal treatment with an Er:YAG laser compared to ultrasonic instrumentation:a pilot study显示文摘 | Sculean A Schwarz F Berakdar M | 2004 | J Periodontol2004，75，7： | 1 |
| 11 | Clinical evalua- tion of an Er: YAG laser for nonsurgical treatment of peri-im-plantitis: a pilot study 显示文摘 | Schwarz F Sculean A Rothamel D | 2005 | Clin Oral Implants Res2005，16，1： | 1 |
| 12 | Two-vear clinicalresults following treatment of peri-implantitis lesions using ananocrystalline hydroxyapatite or a naturM bone mineral incombination with a colagen membrane显示文摘 | Schwarz F Sculean A Biding K | 2008 | J Clin Periodon-tol2008，35，1： | 1 |
| 13 | Treatment of intrabony defects with an enamel matrix protein derivative or bioabsorbale membrane:an 8 year follow up split mouth study显示文摘 | Sculean A Schwarz F Miliauskaite A | 2006 | J Periodontol2006，77，11： | 1 |
| 14 | Regeneration of perio- dontal tissues: combinations of barrier membranes and graft- ing materials --biological foundation and preclinical evidence: a systematic review 显示文摘 | Sculean A Nikolidakis D Schwarz F | 2008 | Journal of Clinical Periodor tology2008，35，8： | 1 |
| 15 | Healing of intra -bony defects following treatment with a composite bovine-derived xenograft (Bio-Os8 collagen) in combination with a collagen membrane CBio-Gide perio) 显示文摘 | Sculean A Chiantella GC Windisch P | 2005 | J Clin Periodontol2005，32，7： | 1 |
| 16 | Clinical evalua- tion of an enamel matrix protein derivative combined with a bioactive glass for the trealment of intrabony periodontal de- fects in humans 显示文摘 | Sculean A Barbe G Chiantella GC | 2002 | J Periodontol2002，73，4： | 1 |
| 17 | Anti-infective therapy with an Er:YAG laser:influence on peri-implant healing显示文摘 | Sculean A Sehwarz F Becker J | 2005 | Expert Rev Med Devices2005，2，3： | 1 |
| 18 | Pattern of mineralization after regenerative periodontal therapy with enamel matrix proteins显示文摘 | Bosshardt DD Sculean A Donos N | 2006 | Eur J Oral Sci2006，114，1： | 1 |
| 19 | Two-year clinical results following treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane显示文摘 | Schwarz F Sculean A Bieling K | | 0，，01： | 1 |
| 20 | In vivo effects of an Er YAG laser,an ultrasonic system and scaling and root planning on biocompatibility of periodontally diseased root surface in cultures of human PDL fibroblasts显示文摘 | Schwarz F Aoki A Sculean A | 2003 | J Clin Periodontol2003，30，2： | 1 |
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