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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | A greedy algorithm for aligning DNA sequences 显示文摘 | Zhang Z Schwartz S Wagner L | 2000 | Journal of Computational Biology2000，7，： | 1 |
| 3 | HPLC separation of Cis-trans carotene Isomers in fresh and processed fruits and vegetables显示文摘 | L A Chandler S J Schwartz | 1987 | J Food Science1987，52，3： | 1 |
| 4 | Ruboxistaurin mesilate hydrate for diabetic retinopathy 显示文摘 | Schwartz S G Flynn H W Aiello L P | 2009 | Drugs Today2009，45，4： | 1 |
| 5 | Phase I trial and pharmaeokinetic study of high-dose elofarabine and busulfan and allogeneic stem cell transplantation in adults with high-risk and refractory acute leukemia 显示文摘 | FARAG S S WOOD L L SCHWARTZ J E | 2011 | Leukemia2011，25，4： | 1 |
| 6 | Detection of macrolide resistance in Mycoplasma pneumoniae by real - time PCR and high - resolution melt analysis 显示文摘 | Wolff B J Thacker W L Schwartz S B | 2008 | Antimicrob AgentsChemother2008，52，10： | 1 |
| 7 | Phase 13 study of sorafenibin patients with advanced hepatocellular carcinoma显示文摘 | Abou-Alfa GK Schwartz L Ricci S | 2006 | J Clin Oncol2006，24，26： | 1 |
| 8 | Basal insulin therapy in typy 2 diabates: 27 -week comparison of insulin glargine ( HOE901 ) and NPH insulin 显示文摘 | Rosenstock J Schwartz S L Clark C Jr | 2001 | Diabetes Care2001，24，11： | 1 |
| 9 | Meiosis I arrest and a-zoospermia in an infertile male explained by failure of for-mation of a component of the synaptonemal complex显示文摘 | Judis L Chan ER Schwartz S | 2004 | Fertil Steril2004，81，1： | 1 |
| 10 | Basal insulin therapy 2 diabetes: 27 week comparison of insulin glargine (HOM901) and NPH insulin 显示文摘 | Rosenstock J Schwartz S L Clark C | 2001 | Diabetes Care2001，24，11： | 1 |
| 11 | Phase II study of sorafenib in patients with advanced hepatocellular carcinoma显示文摘 | Abou-Alfa GK Schwartz L Ricci S | 2006 | J Clin Oncol2006，24，： | 1 |
| 12 | Biclique communities 显示文摘 | LEHMANN S SCHWARTZ M HANSEN L K | 2008 | Physical Review E2008，78，01： | 1 |
| 13 | Dewetting patterns in a drying liquid film 显示文摘 | Schwartz L W Roy R V Eley R R Petrash S | 2001 | Journal of Colloid and Interface Science2001，234，2： | 1 |
| 14 | Phase 11 study of sorafenib in patients with advanced hepatocellular carcinoma 显示文摘 | Abou-Alfa GK Schwartz L Ricci S | 2006 | J Clin Oncol2006，24，26： | 1 |
| 15 | Calcium nephrolithiasis; effect of water hardness on urinary electrolytes 显示文摘 | Schwartz B F Schenkman N S Bruce J E Leslie S W Stoller M L | 2002 | Urology2002，60，： | 1 |
| 16 | Spinodal Decom- position in a Cu- 9wt% Ni -6wf% Sn Alloy 显示文摘 | Schwartz L H Mahajan S Plewes J T | 1974 | Aeta Metall1974，22，5： | 1 |
| 17 | Tryptase precursors are preferentially and spontaneously released, whereas mature tryptase is retained by HMC-1 cells, Mono-Mac-6 cells, and hu- man skin-derived mast cells 显示文摘 | Schwartz L B Min H K Ren S | 2003 | J lmmunol2003，170，11： | 1 |
| 18 | Lyopene:Chemical and biological properties显示文摘 | Nguyen M L Schwartz S | 1999 | Food Technol1999，53，2： | 1 |
| 19 | Phase Ⅱ study of Sorafenib in patients with advanced hepatoeellular carcinoma 显示文摘 | Abou-Alfa GK Schwartz L Ricci S | 2006 | J Clin Oncol2006，24，： | 1 |
| 20 | Pharmacological preconditioning with diazoxide slows energy metabolism during sustained ischemia 显示文摘 | Schwartz L M Reimer K A Crago M S | 2007 | Exp Clin Cardiol2007，12，3： | 1 |
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