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| 1 | 青藏高原纳木错湖阶沉积的发生特征及环境指示意义显示文摘选取的21个湖相沉积物样品分别采自纳木错湖西岸塔吉古日(剖面NamCo1)和纳木错湖东北岸的干玛弄附近(剖面NamCo2)。按照其发生特征分别将剖面从顶部到底部划分为12个和9个层次,通过分析各个层次沉积物的粒径分布特征、质地组成特点、总有机碳(TOC)、总无机碳(TIC)、总碳(TC)的百分含量、酸度值(pH)、电导率(EC)、含水量等若干环境指示因子。结果显示:无论在比较两个剖面的发生特征,还是环境指示因子特征,剖面NamCo1发育程度较剖面NamCo2更加发育;通过对测年数据结果分析,两个剖面均形成于晚更新世,并且通过比较各自剖面在垂直方向上的各项环境指示因子的变化趋势,可知纳木错湖流域在晚更新世(约40kaBP)阶段发生过3次相对明显的冷暖交替过程. | 王利强 易朝路 Brigitta Schutt 董国成 | 2009 | 沉积学报2009，27，3： | 5 |
| 2 | Development and validation of a measure of emotional intelligence显示文摘 | Nicola S. Schutte John M. Malouff Lena E. Hall Donald J. Haggerty Joan T. Cooper Charles J. Golden Liane Dornheim | 1998 | Personality and Individual Differences1998，，2： | 3 |
| 3 | HIV-1蛋白酶抑制剂Nelfinavir降低大鼠胰岛素瘤INS-1细胞胰岛素释放显示文摘HIV 1蛋白酶抑制剂Nelfinavir处理 48h ,显著降低大鼠INS 1细胞基础胰岛素分泌和葡萄糖刺激的胰岛素释放 ,Nelfinavir对后者的抑制作用更强 ,提示Nelfinavir长期治疗可能导致胰岛 β细胞功能损害。 | 周嘉强 Morten Schutt | 2004 | 中华内分泌代谢杂志2004，20，5： | 2 |
| 4 | Capacitive Deionization Technology?: An alternative desalination solution显示文摘 | T.J. Welgemoed C.F. Schutte | 2005 | Desalination2005，，1： | 2 |
| 5 | Nelfinavir损害鼠胰岛素瘤INS-1细胞内IRS-2信号传导显示文摘目的 :探讨 HIV- 1蛋白酶抑制剂 nelfinavir对胰岛 β细胞内胰岛素信号传导蛋白磷酸化的影响。方法 :体外观察鼠胰岛素瘤 INS- 1细胞经 nelfinavir治疗 4 8h后 ,用 10 0 nmol/ L胰岛素刺激 2 min,细胞裂解产物中的胰岛素信号传导蛋白磷酸化采用免疫沉淀和 Western印迹方法测定。用台盼蓝染色细胞计数和 MTT衰减试验 ,评估nelfinavir对 INS- 1细胞活力的影响。结果 :nelfinavir降低胰岛素刺激的胰岛素受体底物 IRS- 2和 Akt- Thr3 0 8磷酸化 ,并呈剂量依赖关系。nelfinavir浓度为 10 μmol/ L时 ,分别降低 IRS- 2和 Akt- Thr3 0 8磷酸化达 5 2 %和 5 5 % ,在这个浓度下 nelfinavir没有细胞毒性作用。结论 :nelfinavir治疗可以损害胰岛 β细胞内 IRS- | 周嘉强 项尊 Morten Schutt | 2004 | 浙江大学学报(医学版)2004，33，4： | 2 |
| 6 | Maternal mortality and severe maternal morbidity from acute fatty liver of pregnancy in the Netherlands显示文摘 | Ruth R. Dekker Joke M. Schutte Jelle Stekelenburg Joost J. Zwart Jos van Roosmalen | 2011 | European Journal of Obstetrics and Gynecology2011，，1： | 2 |
| 7 | Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function显示文摘BACKGROUND MicroRNAs(miRNAs)have been suggested as biomarkers for malignant diseases including hepatocellular carcinoma(HCC).Specifically,hsa-miR-21-5p(miR-21)is among the most frequently deregulated miRNA in cancer.The diagnostic and prognostic value of miR-21 has been demonstrated in HCC tissue,mostly in the Asian population.Although the impact of various factors has been recently reported for circulating hsa-miR-122-5p(miR-122),at present only limited knowledge is available for miR-21.AIM To evaluate the value of miR-21 for the assessment of prognosis in HCC patients and to delineate the influence of clinical and preanalytical factors on miR-21 level in sera.METHODS Patients with confirmed HCC from our European cohort with predominantly alcohol-associated liver damage were included in the study.All subjects were characterized according to their clinical and laboratory work-up and overall survival data were obtained.Quantitative real-time polymerase chain reaction was performed for miR-21 and spiked-in cel-miR-39-3p.The results were compared to previously reported miR-122 data.RESULTS Survival of HCC patients was comparable between patients with low and high serum miR-21 concentration.No association was observed between miR-21 level in sera and Child-Pugh score,Barcelona Clinic Liver Cancer staging system,or etiology of HCC/liver disease.Age,gender,or pretreatment had no association with miR-21 level.A positive correlation was observed between miR-21 and aspartate aminotransferase(r=0.2854,P=0.0061),serum miR-122(r=0.2624,P=0.0120),and the International Normalized Ratio(r=0.2065,P=0.0496).Negative correlation of miR-21 with serum creatinine(r=-0.2215,P=0.0348)suggests renal function as a potential influencing factor in miR-21 biogenesis in blood.CONCLUSION The results from this work do not support clinically relevant prognostic value of circulating miR-21 in HCC patients in real-life settings.Following systematic evaluation,we identified renal function and aspartate aminotransferase as potential factors that may affect miR-21 concentration in blood.This knowledge should be considered in future miRNA-based biomarker studies not only for HCC but also for other diseases. | Martin Franck Cosima Thon Kerstin Schutte Peter Malfertheiner Alexander Link | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 8 | Replacement value for DL-methionine in male broiler chicks 显示文摘 | Schutte J B Jong J Smink W | 1997 | Poult Sci1997，76，： | 1 |
| 9 | Optimized conditions for cloning PCR products into an Xcm I T-vector 显示文摘 | SCHUTTE B C RANADE K PRUESSNER J | 1997 | Biotechniques1997，22，1： | 1 |
| 10 | The factorial validity of the Maslach Burnout Inventory-General Survey (MBI-GS) across oc- cupational groups and nations显示文摘 | Schutte N Toppinen S Kalimo R | 2000 | Journal of Occupational and Organizational Psychology2000，73，1： | 1 |
| 11 | Effects on chick performance and nutrient digestibility of an endo-xylanase added to a wheat-and rye-based diet显示文摘 | LANGHOUT D J SCHUTTE J B GEERSE C | 1997 | British Poultry Science1997，38，： | 1 |
| 12 | Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes显示文摘 | KONDO S SCHUTTE B C RICHARDSON R J | 2002 | Nat Genet2002，32，： | 1 |
| 13 | Direct and indirect relationships between emotional intelligence and subjective fatigue in university students显示文摘 | Brown R F Schutte N S | 2006 | Journal of Psychosomatic Research2006，60，： | 1 |
| 14 | Discovery of five conserved beta-defensin gene dusters using a computational search strategy 显示文摘 | SCHUTTE BC MITROS JP BARTLETT JA | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 15 | Connections between emotional intelligence and workplace flourishing显示文摘 | Schutte NS Loi NM | 2014 | Personality and Individual Differ- ence2014，66，： | 1 |
| 16 | In vivo protective effect of tumour necrosis factor alpha against experimental infection with herpes simplex virus type 1显示文摘 | Rossol-Voth R Rossol S Schutt KH | 1991 | J Gen Virol1991，，72： | 1 |
| 17 | DPC4 gene alterations in human cancer,and their functional implications显示文摘 | | 1999 | Ann Oncol1999，10，4： | 1 |
| 18 | Leptin is independently associated with systolic blood pressure, pulse pressure and arterial comp liance in hyperte sive African women with increased adiposity: the powirs study 显示文摘 | Schutte R Huisman HW Schutte AE | 2005 | Hum Hypertens2005，19，： | 1 |
| 19 | A novel murine β - Defensin expressed in tongue, sophagus and trachea显示文摘 | Jia H Wowk SA Schutte BC etal | 2000 | JBiol Chem2000，275，33： | 1 |
| 20 | Technical aspects of extractive enzyme purifieation显示文摘 | KULA M R HUSTEDT H SCHUTTE H | 1987 | Am NY Acad Sci1987，396，： | 1 |
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