|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Exerclse-stimulated glucase transport in skeletal muscle is nitric oxide dependent显示文摘 | Roberts C K Barnard R J Scheck S H | 1997 | Am J Physiol1997，273，： | 1 |
| 3 | De tection of porcine teschovirus and enteroviruses by Lightcycler real-time PCR显示文摘 | KRUMBHOLZ A WURM R SCHECK O | 2003 | J Virol Methods2003，113，： | 1 |
| 4 | A research note on male - female differentials in the experience of heterosexual love 显示文摘 | Kanin E J Davidson K R Scheck S R | 1970 | Journal of sex research1970，6，： | 1 |
| 5 | The Force Density Method for Form Finding and Computations of General Networks显示文摘 | Scheck H J | 1974 | Computation Methods in Applied Mechanics and Engineering1974，，3： | 1 |
| 6 | Pedicle fat grafts for the prevention of scar in low-back surgery: a preliminary report on the first 92 cases显示文摘 | Gill GG Scheck M Kelley ET | 1985 | Spine1985，10，7： | 1 |
| 7 | Degradation of phenol and salicylic acid by ultraviolet radiation/hydrogen peroxide/oxygen 显示文摘 | Scheck C K Frimmel F H | 1995 | Water Res1995，29，10： | 1 |
| 8 | Antieancer activit of extracts derived from themature roots of Scutellaria bacalensis on human malignant brain tumor cells 显示文摘 | SCHECK A C PERRY K HANK N C | 2006 | BMC Complement Atem Med2006，16，6： | 1 |
| 9 | Charting biologically relevant chemical space: a structural classifica- tion of natural products (SCONP) 显示文摘 | Koch MA Schuffenhauer A Scheck M | 2005 | PNAS2005，102，17： | 1 |
| 10 | Comparison of Three Patent Foramen Ovale Closure Devices in a Randomized Trial (Amplatzer Versus CardioSEAL-STARflex Versus Helex Occluder)显示文摘 | Margaret Taaffe Evelyn Fischer Andreas Baranowski Nicolas Majunke Corinna Heinisch Michaela Leetz Ralph Hein Yves Bayard Franziska Büscheck Madlen Reschke Ilona Hoffmann Nina Wunderlich Neil Wilson Horst Sievert | 2008 | The American Journal of Cardiology2008，，9： | 1 |
| 11 | Surgical treatment of the surgical neck of humerus 显示文摘 | Scheck M | 1982 | Clin Orthop Relat Res1982，，167： | 1 |
| 12 | Reduction of motion sickness in prehoapital trauma care显示文摘 | FLEISCHHACKL R DORNER C SCHECK T | 2003 | Anaesthesia2003，58，4： | 1 |
| 13 | Coping with an or- ganizational merger over four stages 显示文摘 | Fugate M Kinicki A J Scheck C L | 2002 | Personnel Psy- chology2002，，4： | 1 |
| 14 | Degenerative joint disease of the canine hip : experimental production by multiple papain and prednisone injections显示文摘 | Scheck M Sakovich L | 1972 | Clinical Orthopaedics and Related Research1972，86，： | 1 |
| 15 | Developing and testing a model of survivor responses to layoffs显示文摘 | Davy J.A Kinichi A.J Scheck C.L | | 0，，03： | 1 |
| 16 | Exercise-stimulated glucose transport in skeletal muscle is nitric oxide dependent显示文摘 | Roberts C K Barnard R J Scheck S H | 1997 | Am J Physiol Endocrinol Metob1997，273，： | 1 |
| 17 | Degradation of phenol and salicylic acid by ultraviolet radiation hydrogen peroxide oxygen 显示文摘 | SCHECK C K FRIMMEL F F | 1995 | Water Research1995，29，10： | 1 |
| 18 | The Burned-out college student: a descriptive profile显示文摘 | Meier SF Scheck RR | 1985 | J Coil Stud Pers1985，26，1： | 1 |
| 19 | Cardiovascular efects of forces applied during laryngoscopy 显示文摘 | BUCX M J VAN GEEL R T SCHECK P A | 1992 | Anaesthesia1992，47，： | 1 |
| 20 | Heterogeneous tectonic inversion of the Mid-Polish Trough related tO crustal architecture,sedimentary patterns and structural inheritance显示文摘 | Lamarche J Scheck M Lewerenz B | 2003 | Tectonophysics2003，373，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员