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| 1 | Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein显示文摘瞄准:肝炎 B 蛋白质 X (HBx ) 被显示了是弱 oncogenic 在试管内。HBx 的转变活动与肿瘤的功能压制的几的抑制或 p53 被连接了。我们学习了 HBx 是否可以在取决于房间类型的 p53 上有不同效果。方法:我们使用了人的肝细胞瘤房间线 HepG2 和使不朽的鼠科的 hepatocyte 线 AML12 并且稳定地分析了表示了 HBx 的生理的数量的 transfected 克隆。P53 被紫外照耀导致。结果:由紫外照耀的 p53 正式就职由 HBx 的稳定的表示是未受影响的。然而,变得被 p53 激活的 cyclin 激酶禁止者 p21 (waf/cip/sdi ) 的表示在 HBx 被影响转变房间线 AML12-HBx9,然而并非在 HepG2。在 AML-HBx9,房间, p21 (waf/cip/sdi ) 蛋白质表示和 p21 (waf/cip/sdi ) 抄写是 deregulated。而且, apoptosis 的过程在调查的二根房间线以相反的方法被影响。当 HBx 的稳定的表示提高了紫外照耀在 HepG2 房间导致的 apoptosis 时, apoptosis 在 HBx 被减少转变 AML12-HBx9。P53 镇压了从 HBV enhancer 的抄写我,当由紫外照耀从表示向量或在内长的 p53 的正式就职以后表示了时。由内长的 p53 的压抑由在两根房间线的稳定地表示的 HBx 部分是可逆的。结论:HBx 的稳定的表示导致取决于使用的房间线的紫外照耀导致的 apoptosis 的解除管制。而在癌的表示导出 hepatocyte 线 HBx,在一根使不朽的 hepatocyte 线, HBx 扮演了 anti-apoptotic 提高的 apoptosis。 | Nicola Fiedler Ellen Quant Ludger Fink Jianguang Sun Ralph Schuster Wolfram H Gerlich Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，29： | 8 |
| 2 | Genotype-dependent activation or repression of HBV enhancer Ⅱ by transcription factor COUP-TF1显示文摘AIM: To study the expression of HBV enhancer Ⅱ by transcription factor COUP-TF1. METHODS: In order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer Ⅱ from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells. RESULTS: Our fi ndings show that enhancer Ⅱ of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer Ⅱ constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP- TF1. CONCLUSION: Regulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes. | Silke F Fischer Katja Schmidt Nicola Fiedler Dieter Glebe Christian Schüttler Jianguang Sun Wolfram H Gerlich Reinald Repp Stephan Schaefer | 2006 | World Journal of Gastroenterology2006，12，37： | 2 |
| 3 | Evidence of clonality in chronic neutrophilic leukaemia显示文摘 | J BOHM S KOCK H E SCHAEFER | 2003 | J Clin Pathol2003，56，： | 1 |
| 4 | Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells显示文摘 | Von Meyenn F Schaefer M Weighardt H | 2006 | Immunobiology2006，211，68： | 1 |
| 5 | Multivesicular liposome(DepoFoam) technology for the sustained delivery of insulin-like growth factor-Ⅰ(IGF-I)显示文摘 | KATRE NV ASHERMAN J SCHAEFER H | 1998 | J Pharm Sci1998，87，11： | 1 |
| 6 | Concerted Unimolecular Triple Dissociation of s-Tetrazlne:Translation-State Structural Optimizations Using Configuration Interaction and Coupled Cluster Methods显示文摘 | Scuseria G Schaefer H F | 1990 | J Phys Chem1990，94，： | 1 |
| 7 | Characterization and identification of eytoehrome P450 metabolites of arachidonic acid released by human peritoneal maerophages obtained from the pouch of Douglas显示文摘 | Werner K Schaefer W R Schweer H | 2002 | Prastaglandins Leukot Essent Fatty Acids2002，67，6： | 1 |
| 8 | Analysis of the fac- tots influencing energy consumption in industry: a revised method 显示文摘 | REITLER W RUDOLPH M SCHAEFER H | 1987 | Energy Economics1987，14，1： | 1 |
| 9 | New derivatives of vitamin B12 show preferential targeting of tumors 显示文摘 | WAIBEL R TREICHLER H SCHAEFER NG | 2008 | Cancer Res2008，68，8： | 1 |
| 10 | Adding protein context to the human protein -protein interaction network to reveal meaningful inter- actions显示文摘 | SCHAEFER M H LOPES T J S MAH N et at | 2013 | PLoS Comput Biol2013，9，10： | 1 |
| 11 | Toll like receptor 9 contributes to recognition of Mycobacterium boris Bacillus Calmette-Gurin by Flt3-1igand generated dendritic cells显示文摘 | von Meyenn F Schaefer M Weighardt H | 2006 | Immunobiology2006，211，： | 1 |
| 12 | A therapeutic platelet transfusions strategy is safe and fessible in patients after autologous peripheral stem cell transplantation显示文摘 | Wand H Schaefer F Frank M | 2006 | Bone Marrow Transplant2006，37，4： | 1 |
| 13 | Determination of bisphenol A diglycidyl ether (BADGE) and its derivatives in food: identification and quantification by internal standard显示文摘 | PETERSEN A H SCHAEFER C BUCKOW A | 2003 | Eur Food Res Technol2003，216，： | 1 |
| 14 | Atomic and molecular electron affinities: Photoelectron experiments and theoretical computations 显示文摘 | RIENSTRA-KIRACOFE J C TSCHUMPER G S SCHAEFER H F | 2002 | Chem Rev2002，102，： | 1 |
| 15 | Ring opening of cyclopropylidene and internal rotation of allene显示文摘 | Bettinger H F Schreiner P R Schaefer H F | 1996 | J Phys Chem1996，100，16： | 1 |
| 16 | Posterior leucoen- eephalopathy without severe hypertension: utility of diffusion- weighted MRI显示文摘 | Ay H Buonanno FS Schaefer PW | 1998 | Neurology1998，51，5： | 1 |
| 17 | 1- methylcyclopro- pene Preserves the firmness of plums during postharvest storage and ripening 显示文摘 | Skoy L J Schaefer B H Smith P G | 2001 | Acta Horticultural2001，553，1： | 1 |
| 18 | Effect of CNC- milling on the marginal and internal fit of dental ceramics: a pilot study显示文摘 | Schaefer O Kuepper H Thompson GA | 2013 | Dent Mater2013，29，8： | 1 |
| 19 | Chronic neutrophilic leukaemia: 14 new cases of an uncommon myeloproliferativedisease显示文摘 | J BOHM H E SCHAEFER | 2002 | J Clin Pathol2002，55，： | 1 |
| 20 | Near-synchronous interhemispheric termination of the Last Glacial Maximum in mid- latitudes 显示文摘 | Schaefer J M Denton G H Barrell D J A | 2006 | Science2006，312，： | 1 |
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