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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Au nanoparticles target cancer显示文摘 | Jain P K El - Sayed I H and El - Sayed M A | 2007 | Nano Today2007，2，1： | 1 |
| 3 | Variation in dry matter and grain filling characteristics in wheat cultivars显示文摘 | Sayed H I | 1983 | Field Crops Research1983，7，1： | 1 |
| 4 | Functionalized single graphene sheets derived from splitting graphite oxide 显示文摘 | Schniepp H C Li J L McAllister M J Sai H Herrera Alonso M Adamson D H Prud'Homme R K Car R Saville D A Aksay I A | 2006 | J Phys Chem B2006，110，17： | 1 |
| 5 | Possible role of anion exchanger AE2 as the Intestinal monocarboxylic acid/anion antiporter 显示文摘 | YABUUCHI H TAMAI I SAI Y | 1998 | Pharm Res1998，15，3： | 1 |
| 6 | J Catal显示文摘 | Rukhsana I K Noor-ul H K Sayed H K A | 2004 | 224:2292004，224，： | 1 |
| 7 | Effect of soil salinity and water stresses on growth and content of nitrogen, chloride and phosphate of wheat and triticale显示文摘 | Mashhady A H Sayed H I Heakal M S | 1982 | Plant and Soil1982，68，2： | 1 |
| 8 | Variation in drymater and grain filling eharaeteristies in wheat eultivars显示文摘 | Sayed H I Gadallan A M | 1983 | Field Crops Research1983，7，1： | 1 |
| 9 | Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics:applications in oral cancer显示文摘 | EI SAYED I H HUANG X H EI-SAYED M A | 2005 | Nano Lett2005，5，5： | 1 |
| 10 | Diffusionleast - mean squares with adaptive combiners : formulationand performance analysis 显示文摘 | TAKAHASHI N YAMADA I SAYED A H | 2010 | IEEE Transactions onSignal P rocessing2010，58，9： | 1 |
| 11 | Review of some in- teresting surface plasmon resonance - enhanced properties of noble met- al nanoparticles and their applications to biosystems 显示文摘 | JAIN P K HUANG X H EL - SAYED I H | 2007 | Plasmonics2007，，2： | 1 |
| 12 | Diffusion Least -Mean Squares with Adaptive Combiners: Formula- tion and Performance Analysis显示文摘 | Takahashi N Yamada I Sayed A H | 2010 | IEEE Transactions on Signal Processing2010，58，9： | 1 |
| 13 | Enantioselective epoxidation of nonfunctionalized alkenes catalyzed by recyclable new homochiral dimeric Mn(Ⅲ) salen complexes显示文摘 | Rukhsana I K Noor-ul H K Sayed H K A | 2004 | J Catal2004，224，： | 1 |
| 14 | Effect of soil salinity and water stresses on growth and content of nitrogen, chloride and phosphate of wheat and triticale显示文摘 | Mashhday A S Sayed H I Heakal M S | 1982 | Plant and Soil1982，68，： | 1 |
| 15 | Variation in dry matter and grain filling characteristics in wheat cultivars显示文摘 | Sayed H I | 1983 | Field Crops Reserch1983，7，1： | 1 |
| 16 | A highly potential analogue of Jacobsen catalyst with in-buih phase transfer capability in enantioselective epoxidation of nonfunctionalized alkenes显示文摘 | Rukhsana I K Noorul H K Sayed H R A | 2002 | J Catal2002，209，1： | 1 |
| 17 | Effect of soil salinity and water stresses on growth and content of nitrogen,chloride and phosphate of wheat and triticale显示文摘 | Mashhady A H Sayed H I Heakal M S | 1982 | Plant and Soil1982，68，2： | 1 |
| 18 | Preoperative breast ultrasound and Doppler velocimetric findings in patients with breast cancer显示文摘 | Mansour G M EI-Lamie I K E1 Sayed H M | 2006 | Eur J Gynaecol Oncol2006，27，2： | 1 |
| 19 | Enantioselective epoxidation of chromenes using chiral Mn( Ⅲ) salen catalysts with built-in phase-transfer capability 显示文摘 | Rukhsana I K Noorul H K Sayed H R A | 2002 | Tetrahedron Lett2002，43，14： | 1 |
| 20 | Molecular characterization of a new sero- type of duck hepatitis virus 显示文摘 | TSENG C H I'SAI H J | 2007 | Virus Res2007，126，： | 1 |
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