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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 3 | Linear estimation in Krein spaces part Ⅱ: Applications 显示文摘 | Sayed A H Kailath T | 1996 | IEEE Transactions on Automatic Control1996，41，1： | 1 |
| 4 | Networkbased wireless location显示文摘 | Sayed A H Tarighat A Khaiehnouri N | 2005 | IEEE Signal Processing Magazine2005，，7： | 1 |
| 5 | Optimal linear cooperation for spectrum sensing in cognitive radio networks 显示文摘 | QUAN Z CUI SH G SAYED A H | 2008 | IEEE Selected in Signal Processing2008，2，1： | 1 |
| 6 | Solar selective ab- sorbers based on two-dimensional W surface gratings with submicron periods for high-temperature photothermal con- version显示文摘 | Sai H Yugami H Kanamori Y | 2003 | Solar Energy Mater Solar Cells2003，79，： | 1 |
| 7 | Multi-input multi-output fading channel tracking and equalization using Kalman estimation 显示文摘 | Komninakis C Fragouli C Sayed A H | 2002 | IEEE Transactions on Signal Processing2002，50，5： | 1 |
| 8 | Fundamentals of alternative dispute resolution processes in construction显示文摘 | Sai On Cheung Henry C H Suen Tsun-Ip Lam | 2002 | Journal of Construction Engineering and Management2002，128，2： | 1 |
| 9 | A feedback approach to the steady-state performance of fractionally fractionally spaced blind ada- ptive equalizers显示文摘 | J Mai A H Sayed | 2000 | IEEE Transactions on Signal Process- ing2000，48，1： | 1 |
| 10 | Au nanoparticles target cancer显示文摘 | Jain P K El - Sayed I H and El - Sayed M A | 2007 | Nano Today2007，2，1： | 1 |
| 11 | Platelet-derived growth factor- BB(PDGF-BB)induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells,and changes the phenotype显示文摘 | Miyata T Lizasa H Sai Y | 2005 | Cell Physiol2005，204，3： | 1 |
| 12 | Adaptive tracking of linear time-variant systems by extended RLS algorithms显示文摘 | Haykin S Sayed A H Zeidler J R | 1997 | IEEE Transactions on Signal Processing1997，45，5： | 1 |
| 13 | Endovascular ab- dominal aortic aneurysm repair in patients with ventricular assist devices 显示文摘 | Starr JE Elsayed - Awad H Sai - Sudhakar CB | 2014 | J Cardiovasc Surg ( Torino )2014，55，2： | 1 |
| 14 | Multi-input multi- output fading channel tracking and equalization using Kalman esti- mation 显示文摘 | Komninakis C Fragouli C Sayed A H | 2002 | Signal Processing IEEE Transactions on2002，50，5： | 1 |
| 15 | A Leakage-Based Precoding Scheme for Downlink Multi-User MIMO Channels显示文摘 | MIRETTE SADEK ALIREZA TARIGHAT ALI H SAYED | 2007 | IEEE Transactions on Wireless Communications2007，6，5： | 1 |
| 16 | The expression of vascular endothelial growth factor and proliferative activity of cancer cells in gastric cancer 显示文摘 | Ikeguchi M Oda S Sai H | 1999 | Langenbecks Arch Surg1999，384，3： | 1 |
| 17 | Evolutionary algorithms,simulated annealing and tabu search:a comparative study显示文摘 | Youssef H Sai S M Adiche H | 2001 | Engineering Applications of Artificial Intelligence2001，14，2： | 1 |
| 18 | Variable step-size nlms and affine projection algorithm显示文摘 | SHIN H C SAYED A H SONG W J | 2004 | IEEE Signal Processing Letters2004，11，2： | 1 |
| 19 | Variation in dry matter and grain filling characteristics in wheat cultivars显示文摘 | Sayed H I | 1983 | Field Crops Research1983，7，1： | 1 |
| 20 | Optimal Linear Cooperation for Spectrum Sensing in Cognitive Radio Networks显示文摘 | QUAN Zhi CUI Shuguang SAYED A H | 2008 | IEEE Journal of Selected Topics in Signal Processing2008，2，1： | 1 |
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