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| 1 | 卒中治疗专业学术圆桌会议临床前推荐更新版显示文摘首份卒中治疗专业学术圆桌会议(Stroke Yherapy Academic Industry Roundtable,STAIR)推荐于1999年出版,旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的,但并未得到严格的遵循和验证。为了更好地向临床转化,有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议,即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括:高质量科学研究的基本原则应消除随机和评价偏倚,预先确定纳入和排除标准,计算合适的效能和样本量,并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后,在雌性、高龄动物和伴有合并症(如高血压、糖尿病和高胆固醇血症)的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性,但遵循这些推荐有望提高成功的机会。 | Marc Fisher Giora Feuerstein David W. Howells Patricia D. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) | 2009 | 国际脑血管病杂志2009，17，8： | 5 |
| 2 | Stem cell therapy as an emerging paradigm for stroke ( STEPS) Ⅱ显示文摘Cell-based therapies represent a new therapeutic approach for stroke.In 2007,investigators from academia,industry leaders,and members of the National Institutes of Health crafted recommendations to facilitate the | Savitz SI Chopp M Deans R Carmichael ST Phinney D Wechsler L | 2011 | 中华神经外科疾病研究杂志2011，10，3： | 5 |
| 3 | Apoptosis in neurological disease显示文摘 | Savitz SI Rosenbaum DM | 1998 | Neurosurgery1998，42，3： | 1 |
| 4 | Neuropsychological dysfunction in bipolar affective disorder: a critical opinion显示文摘 | Savitz J Solms M Rarnesar R | 2005 | Bipolar Disord2005，7，3： | 1 |
| 5 | Effect of parents' occupational exposures on risk of stillbirth, preterm delivery, and small for gestational age infants 显示文摘 | Savitz DA Whelan EA Kleckner RC | 1989 | Am J Epidemiol1989，129，6： | 1 |
| 6 | Erythropoietin administration protects restinal neurons from acute ischemica-reperfusion injury显示文摘 | Junk AK Mammis A Savitz SL Singh M Roth S Malhotra S | 2002 | PNAS2002，99，10： | 1 |
| 7 | Vertebrobasilar disease 显示文摘 | Savitz S I Caplan L R | 2005 | N Engl J Med2005，352，25： | 1 |
| 8 | Vertebral artery compression of the medulla显示文摘 | Savitz SI Michael R Caplan LR | 2006 | Arch Neurol2006，63，： | 1 |
| 9 | A Rare Case of Anaphylaxis to Bowel Prep: A Case Report and Review of the Literature显示文摘 | Savitz J A Durning S J | 2011 | Mil Med2011，176，8： | 1 |
| 10 | Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippoeampal and amygdalar volumes in subjects with major depressive disorder 显示文摘 | Savitz J Drevets WC Smith CM | 2015 | Neuropsychopharmaeology2015，40，2： | 1 |
| 11 | Cell transplants offer promise for stroke recovery显示文摘 | Savitz S L Malhotra S Gupta G | 2003 | Cardiovasc Nurs2003，18，1： | 1 |
| 12 | Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials显示文摘 | Savitz S Fisher M | 2007 | Ann Neurol2007，61，： | 1 |
| 13 | Reviving neuroprotection using a new ap- proach: targeting postsynaptic density-95 to arrest glutamate显示文摘 | Savitz SI Schabitz WR | 2012 | Stroke2012，43，12： | 1 |
| 14 | Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring显示文摘 | Teschke K Savitz D | 2001 | Epidemiology2001，12，5： | 1 |
| 15 | Apoptosis in the retina显示文摘 | Rosenbaum PS Gupta H Savitz SI | 1997 | Clin Neurosci1997，4，5： | 1 |
| 16 | Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury 显示文摘 | Junk AK Mammis A Savitz SI | 2002 | Proc Natl Acad Sci USA2002，99，10： | 1 |
| 17 | Ethnic differences in the associa- tion between gestational diabetes and pregnancy outcome 显示文摘 | Mocarski M Savitz DA | 2012 | Matern Child Health J2012，16，2： | 1 |
| 18 | Maternal exposure to neighborhood carbon monoxide and risk of low birth weight 显示文摘 | ALDERMAN B W BARON A E SAVITZ D A | 1987 | Public Health Report1987，102，： | 1 |
| 19 | Magnetic field exposure and cardiovascular disease mortality among electric utility workers 显示文摘 | SAVITZ D A LIAO D SASTRE A | 1999 | Am J Epidemiol1999，149，2： | 1 |
| 20 | Review of epidemiologic studies of paternal occupational exposure and spontaneous abortion 显示文摘 | Savitz DA Sonnenfeld NL Olshan AF | 1994 | Am J lnd Med1994，25，3： | 1 |
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