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| 1 | Nuclear magnetic resonance based metabolomics and liverdiseases:Recent advances and future clinical applications显示文摘Metabolomics is defined as the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification.It is an'omics'technique that is situated downstream of genomics,transcriptomics and proteomics.Metabolomics is recognized as a promising technique in the field of systems biology for the evaluation of global metabolic changes.During the last decade,metabolomics approaches have become widely used in the study of liver diseases for the detection of early biomarkers and altered metabolic pathways.It is a powerful technique to improve our pathophysiological knowledge of various liver diseases.It can be a useful tool to help clinicians in the diagnostic process especially to distinguish malignant and non-malignant liver disease as well as to determine the etiology or severity of the liver disease.It can also assess therapeutic response or predict drug induced liver injury.Nevertheless,the usefulness of metabolomics is often not understood by clinicians,especially the concept of metabolomics profiling or fingerprinting.In the present work,after a concise description of the different techniques and processes used in metabolomics,we will review the main research on this subject by focusing specifically on in vitro proton nuclear magnetic resonance spectroscopy based metabolomics approaches in human studies.We will first consider the clinical point of view enlighten physicians on this new approach and emphasis its future use in clinical'routine'. | Roland Amathieu Mohamed Nawfal Triba Corentine Goossens Nadia Bouchemal Pierre Nahon Philippe Savarin Laurence Le Moyec | 2016 | World Journal of Gastroenterology2016，22，1： | 6 |
| 2 | MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomy- elitis显示文摘 | Savarin C Bergmann CC Hinton DR | 2013 | ASN Neurol2013，5，5： | 1 |
| 3 | Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play显示文摘 | Chenal A Savarin P Nizard P | | 0，，45： | 1 |
| 4 | Atrocyte response to IFN-7 limits IL-6-mediated mieroglia activation and progressive autoimmune encephalomyelitis 显示文摘 | Savarin C Hinton DR Valentin-Torres A | 2015 | J Neuroinflammation2015，12，： | 1 |
| 5 | Facile reduction ofmalonate derivatives using NaBH4/Br2: An efficient route to 1, 3-diols显示文摘 | Tudge M Mashima H Savarin C | 2008 | TetrahedronLetters2008，49，6： | 1 |
| 6 | Chemokines and che- mokine receptors in neurological disease: raise, retain, or reduce显示文摘 | Savarin - VuaiUat C Ransohoff RM | 2007 | Neumtherapeutics2007，4，4： | 1 |
| 7 | An Expedient Synthesis of Highly Functionalized Naphthyridones and Quinolines from a Common N-aryl Pyridinone Template 显示文摘 | SAVARIN C G MURRY J A DORMER P G | 2002 | Organic Letters2002，4，12： | 1 |
| 8 | MMP-independent role ofTIMP-1 at the blood brain barrier during viral encephalomyelitis显示文摘 | Savarin C Bergmann CC Hinton DR | 2013 | ASN Neuro2013，5，5： | 1 |
| 9 | MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis显示文摘 | Savarin C Bergmann CC Hinton DR | 2013 | ASN Neuro2013，5，00： | 1 |
| 10 | Direct Nacetyl enamine formation:Lithium bromide mediated addition of methyllithium to nitriles 显示文摘 | Savarin C G Boice G N Murry J A | 2006 | Org Lett2006，8，18： | 1 |
| 11 | Development of a novel,highly efficient halide-catalyzed sulfenylation of indoles显示文摘 | Tudge M Tamiya M Savarin C | | 0，，04： | 1 |
| 12 | Astrocyte re- sponse to IFN-γ limits IL--6-mediated microglia activation and progressive autoimmune encephalomyelitis 显示文摘 | Savarin C Hinton DR Valentin-Torres A | 2015 | J Neuroinflam2015，12，1： | 1 |
| 13 | Sialyl Lewisx analogs based on a quinic acid scaffold as the Trehalose mimic显示文摘 | Christian Girard Jennifer Dourlat Aline Savarin | 2005 | Bioorganic & Medicinal Chemistry Letters2005，15，： | 1 |
| 14 | IFN-Y protects from lethal IL-17 mediated viral encephalomyelitis independent of neu- trophils显示文摘 | Savarin C Stohlman SA Hinton DR | 2012 | Neuroinflarmnation2012，9，： | 1 |
| 15 | Three-dimensional structure of k-PVIIA potassium channel-blocking toxin from cone snails显示文摘 | SAVARIN P MARC G BERNARD G | 1998 | Biochemistry1998，37，16： | 1 |
| 16 | Functional anatomy of scorpion toxins affecting sodium channels 显示文摘 | Gordon D Savarin P Gurevitz M | 1998 | J Toxicol Toxin Rev1998，17，2： | 1 |
| 17 | Chemokines and che- mokine receptors in neurological disease: raise, retain, or reduce 显示文摘 | Savarin - Vuaillat C Ransohoff RM | 2007 | Neurotherapeutics2007，4，4： | 1 |
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