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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Credit ratings and the BIS capital adequacy reform agenda 显示文摘 | Altman E I Bharath S T Saunders A | 2002 | Journal of Banking & Finance2002，26，9： | 2 |
| 3 | Forming of tailor-welded blanks显示文摘 | Saunders F I Wagoner R H | 1996 | Metallurgical and Materials Transactions A (USA)1996，27，9： | 1 |
| 4 | Neuraxial drug administration: a review oftreatment op tions for anaesthesia and analgesia显示文摘 | Schug SA Saunders D Kurowski I | 2006 | CNS Drugs2006，20，11： | 1 |
| 5 | Credit risk measurement: Developments over the last 20 years显示文摘 | Saunders A | 1997 | Journal of banking & Finance1997，，21： | 1 |
| 6 | Forming of tailor-welded blanks显示文摘 | Saunders F I Wagoner R H | 1996 | Metallurgical and Materials Transactions A1996，27，9： | 1 |
| 7 | Reactions of possible cellulose liquefaction intermediates under high pressure liquefaction conditions显示文摘 | Miller I J Saunders E R | 1987 | Fuel1987，66，1： | 1 |
| 8 | Endoscopic management of polypoid early colon cancer 显示文摘 | Williams C B Saunders B P Talbot I C | 2000 | World J Surg2000，24，9： | 1 |
| 9 | Credit risk measurement: developments over the last 20 years 显示文摘 | Altman E I Saunders A | 1997 | Journal of Banking & Finance1997，，21： | 1 |
| 10 | Claudin-14 knockout mice,a model for autosomal recessive deafness DFNB29,are deaf due to cochlear hair cell degeneration显示文摘 | Ben-Yosef T Belyantseva I A Saunders T L | | 0，，16： | 1 |
| 11 | Credit risk measurement: Developments over the last 20 years显示文摘 | Edward I Altman Anthony Saunders | 1997 | Journal of Banking and Finance1997，，11： | 1 |
| 12 | Credit Risk Measurement: Developments Over the last 20 Years 显示文摘 | Altman E I A Saunders | 1995 | Journal of Banking and Finance1995，，21： | 1 |
| 13 | Control of fumonisin: effects of processing显示文摘 | Saunders D S Meredith F I Voss K A | 2001 | Environmental Health Perspectives2001，109，2： | 1 |
| 14 | Credit Risk Meas urement: Developments Over the Last 20 Years 显示文摘 | ALTMAN E I SAUNDERS A | 1998 | Journal of Banking and Finance1998，22，3： | 1 |
| 15 | A computer system for continuous long-term recording, processing, and analysis of physiological data of brain injure patients in ICU settings显示文摘 | Saunders F Schierek P | 2003 | Brain Inj2003，15，7： | 1 |
| 16 | Effects of ginsenosides on GABAA and GABAB 显示文摘 | Ho I K Kimura T Saunders P A | 1990 | Recepters1990，14，2： | 1 |
| 17 | The earliest recorded plant virus disease显示文摘 | Saunders K Bedford I D Yahara T | 2003 | Nature2003，422，： | 1 |
| 18 | Microbial evolution, diversity, and ecology: a decade of ribosomal RNA analysis of uncultivated microorganisms 显示文摘 | HEAD I M SAUNDERS J R PICKUP R W | 1998 | Microbial Ecology1998，35，： | 1 |
| 19 | High-rate nonbinary regular quasi-cyclic LDPC codes for optical communications显示文摘 | ARABACI M DJORDJEVIC I B SAUNDERS R | 2009 | Journal of Lightwave Technology2009，27，23： | 1 |
| 20 | Should banks be diversified? Evidence from individual bank loan portfolios 显示文摘 | ACHARYA V V HASAN I SAUNDERS A | 2006 | The Journal of Business2006，，3： | 1 |
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