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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Effect of particle size on the convective heat transfer in nanofluid in the developing regi-on显示文摘 | ANOOP K B SUNDARARAJAN T SARIT K D | 2009 | International Journal of Heat and Mass Transfer2009，52，910： | 1 |
| 3 | An experimental investigation of the port flow maldistribution in small and large plate package heat exchangers显示文摘 | Prabhakara R B Bengt S Sarit K D | 2006 | Int J Applied Thermal Engineering2006，26，： | 1 |
| 4 | The effect of flow maldistribution on the evaluation of axial dispersion and thermal performance during the single blow testing of plate heat exchangers 显示文摘 | SHAJI K SARIT K D | 2010 | International Journal of Heat and Mass Transfer2010，53，： | 1 |
| 5 | Effect of flow distribution to the channels on the thermal performance of a plate heat exchanger显示文摘 | RAO B P KUMAR P K SARIT K D | 2002 | Chemical Engineering and Processing2002，41，1： | 1 |
| 6 | Effect of diameter on two-phase pres- sure drop in narrow tubes显示文摘 | VENKATESAN M SARIT K D BALAKRISH- NAL A R | 2011 | Experimental Ther- mal and Fluid Science2011，35，： | 1 |
| 7 | Effect of tube diameter on two-phase flow patterns in mini tubes显示文摘 | VENKATESAN M SARIT K D BALAKRISHNAN A R | 2010 | The Canadian Journal of Chemical Engi- neering2010，88，6： | 1 |
| 8 | A composite heat transfer model for pool boiling on a horizontal tube at moderate pressure 显示文摘 | Sarit K D Wilfried R | 2004 | The Canadian Journal of Chemical Engineering2004，82，2： | 1 |
| 9 | Temperature dependence of thermal conductivity enhancement for nanofluids显示文摘 | Sarit K D Nandy P | 2003 | Journal of Heat Transfer2003，125，8： | 1 |
| 10 | Leptin modulates lymphocytes' adherence to hepatic stellate cells is associated with oxidative status alterations显示文摘 | Lina AT Sarit D Mahmud M | 2013 | Mitochondrion2013，13，： | 1 |
| 11 | Bidding in sealed-bid andEnglish multi-attribute auctions显示文摘 | Esther D Rina A Sarit K | 2006 | Decision SupportSystems2006，42，2： | 1 |
| 12 | The effect of flow maldistri- bution on the evaluation of axial dispersion and ther- mal performance during the single-blow testing of plate heat exchangers 显示文摘 | SHAJI K SARIT K D | 2010 | International Journal of Heat and Mass Transfer2010，53，7： | 1 |
| 13 | Numerical study of flow and thermal oscillations in buoyant twin jets显示文摘 | Suyambazhahan S Sarit K Sundararjan D T | 2007 | Internationa Communications in Heat and Mass Transfer2007，34，2： | 1 |
| 14 | Bidding in Sealed-bid and English Muhi-attribute Auctions 显示文摘 | ESTHER D RINA A SARIT K | 2006 | Decision Support Systems2006，42，2： | 1 |
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