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| 1 | 外伤性脾破裂317例诊治分析显示文摘目的探讨在条件有限的基层医院中脾破裂患者的诊疗方法。方法回顾性分析瓦努阿图共和国维拉中心医院8年间住院的317例脾破裂患者的临床资料,分析B超诊断的出血情况和非手术治疗、手术治疗的结果。结果B超诊断被膜下出血者30例,真性脾破裂者287例。参考B超结果对29例患者采用非手术治疗,288例采用手术治疗。结论B超诊断脾破裂阳性率高,诊断出血量与手术结果较符合;参考B超结果选择符合脾切除术指征的病例进行手术是治疗脾破裂确切有效的手段。 | 李亿程 王巍 唐健雄 袁祖荣 Santus Wari | 2005 | 中国普通外科杂志2005，14，7： | 10 |
| 2 | 顺势疗法药物山金车30C通过上调核苷酸切除修复基因的表达减少紫外线照射后大肠杆菌的DNA损伤(英文)显示文摘目的:检测高度稀释的顺势疗法药物山金车30C是否能够调节暴露于紫外线照射下的大肠杆菌的核苷酸切除修复基因的表达。方法:大肠杆菌在标准培养基中培养至对数阶段,然后接受亚致死剂量的紫外线照射(25和50 J/m2分别照射22.5和45 s)。接受不同剂量紫外线照射的大肠杆菌分别与山金车30C及安慰剂30C共同培养,90 min后检测其DNA损伤情况及氧化应激状态。采用多种方法及指标如彗星实验、梯度凝胶电泳、细胞内活性氧生成及测量其他生物活性指标如过氧化物歧化酶、过氧化氢酶及谷胱甘肽衡量DNA损伤情况及细胞氧化应激状态。逆转录聚合酶链反应检测大肠杆菌细胞紫外线损伤修复基因uvrA、B、C(核苷酸切除修复基因)mRNA的表达情况。结果:接受照射后的大肠杆菌出现了DNA损伤及氧化应激反应,表现为细胞内活性氧生成增加及过氧化物歧化酶、过氧化氢酶和谷胱甘肽活性降低。与安慰剂组相比,山金车30C降低了大肠杆菌的DNA损伤及氧化应激反应,表现为细胞内活性氧生成减少及过氧化物歧化酶、过氧化氢酶和谷胱甘肽活性增强。与对照组相比,山金车30C上调了大肠杆菌细胞紫外线损伤修复基因的表达。结论:山金车30C能够通过上调紫外线损伤修复基因的表达修复紫外线引起的大肠杆菌细胞的DNA损伤,并通过减少细胞内活性氧的生成及调节抗氧化酶活性降低细胞的氧化应激反应。 | Sreemanti Das Santu Kumar Saha Arnab De Durba Das Anisur Rahman Khuda-Bukhsh | 2012 | 中西医结合学报2012，10，3： | 3 |
| 3 | Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro显示文摘OBJECTIVE: Methylation-specifi c epigenetic process and gene expression profi les of He La cells treated with ultra-high dilutions(HDs) of two plant extracts, Hydrastis canadensis(HC-30) and Marsdenia condurango(Condu-30), diluted 1060 times, were analyzed against placebo 30C(Pl-30) for alterations in gene profi les linked to epigenetic modifi cations.METHODS: Separate groups of cells were subjected to treatment of Condu-30, HC-30, and Pl-30 prepared by serial dilutions and succussions. Global microarray data recorded on Affymetrix platform, using 25-mer probes were provided by i Life Discoveries, India. Slides were scanned with 3000 7G microarray scanner and raw data sets were extracted from Cel(raw intensity) fi les. Analyses of global microarray data profi le, differential gene expression, fold change and clusters were made using Gene Spring GX12.5 software and standard normalization procedure. Before microarray study, concentration of RNA(ng/μL), RIN value and r RNA ratio for all the samples were analysed by Agilant Bioanalyzer 2100. Reverse transcriptase polymerase chain reaction(RT-PCR) and quantitative RTPCR were done for analyzing SMAD-4 expression. Fluorescence-activated cell sorting study was further made to elucidate fate of cells at divisional stages. Methylation-specifi c restriction enzyme assay was conducted for ascertaining methylation status of DNA at specifi c sites.RESULTS: HDs of HC-30 and Condu-30 differentially altered methylation in specifi c regions of DNA and expression profi les of certain genes linked to carcinogenesis, as compared to Pl-30. Two separate cut sites were found in genomic DNA of untreated and placebo-treated He La cells when digested with McrB C, compared to a single cut observed in Condu-30-treated genomic DNA. SMAD-4 gene expression validated the expression pattern observed in microarray profi le. Methylation-specifi c restriction enzyme assay elucidated differential epigenetic modifi cations in drug-treated and control cells.CONCLUSION: HDs triggered epigenetic modifi cations and alterations in microarray gene expression profi les of many genes associated with carcinogenesis in HeLa cells in vitro. | Santu Kumar Saha Sourav Roy Anisur Rahman Khud a-Bukhsh | 2015 | Journal of Integrative Medicine2015，13，6： | 2 |
| 4 | Osmotic drug delivery:a review of the patent literature显示文摘 | Santus G Baker RW | 1995 | J Control Release1995，35，1： | 1 |
| 5 | Tolyporphin: a natural product from cyanobacteria with potent photosensitizing activity against tumor cells in vitro and in vivo显示文摘 | Morliere P Maziere J C Santus R | 1998 | Cancer Res1998，58，： | 1 |
| 6 | Bronchodilator effect of an inhaled comination therpy with salmeterol + fluticasone and formoterol + budesonide in patientswith COPD显示文摘 | Cazzula M Santus P Di Marco F | 2003 | Respir Med2003，97，5： | 1 |
| 7 | Why use long acting bronchodilators in chronic obstructive lung diseases? An extensive review on formotcrol and sahneterol显示文摘 | Santus E Radovanovic D Paggiaro P | 2015 | Eur J Intern Med2015，26，6： | 1 |
| 8 | Transdermal enhancer patent literature显示文摘 | SANTUS G C | 1993 | Controlled Release1993，83，25： | 1 |
| 9 | UVA-induced lipid peroxidation in cultured human fibroblasts显示文摘 | Morliere P Moysan A Santus R | 1991 | Biochem Biophysica Acta1991，1084，： | 1 |
| 10 | Osmotic drug delivery: A review of the patent literature 显示文摘 | SANTUS G BAKER R W | 1995 | J Controlled Release1995，35，： | 1 |
| 11 | Osmotic drug delivery: A review of the patent literature 显示文摘 | Santus G Baker RW | 1995 | J Control Release1995，35，： | 1 |
| 12 | Osmotic drug delivery:a review of the patent literature 显示文摘 | GIANCARLO SANTUS BAKER RW | 1995 | J Control Release1995，35，1： | 1 |
| 13 | A pilot study to assess the effects of combining fluticasone propionate/salmeterol and tiotropium on the airflow obstruction of patients with severe to very severe COPD显示文摘 | Cazzola M Andò F Santus P | | 0，，： | 1 |
| 14 | Anxiety and depression in asthma 显示文摘 | Di Marco F ' Santus P Centanni S | 2011 | Curr Opin Pulm Med2011，17，1： | 1 |
| 15 | Bronehodilating effect of oxitropium bromide in heart disease patients with exacerbations of COPD:double - blind, randomized, controlled study 显示文摘 | Centanni S Santus P | 2002 | Respir Med2002，96，3： | 1 |
| 16 | Impairment of the EGF sign aling pathway by the oxidative stress generated with UVA显示文摘 | Maziere C Floret S Santus R | | 0，，06： | 1 |
| 17 | Close correlation between anxi- ety, depression, and asthma control显示文摘 | Di Marco F Verga M Santus P | 2010 | Respir Med2010，104，1： | 1 |
| 18 | Osmotic drug delivery: a review of the patent literature 显示文摘 | Giancarto Santus Baker RW | 1995 | J Control Release1995，35，1： | 1 |
| 19 | Safety and pharmacological profile of tiotropium bromide显示文摘 | Santus P Di Marco F | 2009 | Expert Opin Drug Saf2009，8，3： | 1 |
| 20 | The role of cefditoren in the treatment of lower community-acquired respiratory tract infections(LRTIs):from bacterial eradication to reduced lung inflammation and epithelial damage显示文摘 | Di Marco F Braido F Santus P | 2014 | Eur Rev Med Pharmacol Sci2014，18，3： | 1 |
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