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3篇 您的检索式:作者名="Sandhya Rai"
    题名 作者 年代 出处 被引量
1Immu nofluores- cence of the outer mot sheath: an aid to diagnosis in pemphigus显示文摘Kumaresan M Rai R Sandhya V 2011Clin Exp I)ermatol2011,36,3:1
2Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine显示文摘Molecular subtypes-based therapies offer new potential framework for desired and precise outcome in clinical settings.Current treatment strategies in colorectal cancer are largely‘one drug fit all’model for patients that display same pathological conditions.However,CRC is a very heterogenous set ofmalignancy that does not support for above criteria.Each subtype displays different pathological and genetic signatures.Based on these features,therapeutic stratification for individual patients may be designed,which may ultimately lead to improved therapeutic outcomes.In this comprehensive review,we have attempted to briefly outline major CRC pathways.A detailed overview of molecular subtypes and their clinical significance has been discussed.Present and futuremethods,governing CRC subtyping in the era of personalized therapywith a special emphasis on CMS subtypes of CRC has been reviewed.Together,discovery and validation of new CRC patient stratification methods,screening for novel therapeutic targets,and enhanced diagnosis of CRC may improve the treatment outcome.Manish Pratap Singh Sandhya Rai Ashutosh Pandey Nand K.Singh Sameer Srivastava 2021Genes & Diseases2021,8,2:1
3Unsupervised machine learning-based clustering identifies unique molecular signatures of colorectal cancer with distinct clinical outcomes显示文摘Colorectal cancer(CRC)is known to harbor considerable heterogeneity.1 Consequently,it could be hypothesized that similar-appearing tumors might exhibit substantial genetic differences while diverse-appearing tumors may have a similar genetic landscape.2 Due to these differences at the molecular level,they behave or respond differently to therapies as well.CRC progression is a multistep process and involves the accumulation of substantial genetic and epigenetic events in a stage-dependent manner.Manish Pratap Singh Sandhya Rai Sarvesh K.Gupta Nand K.Singh Sameer Srivastava 2023Genes & Diseases2023,10,6:0
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