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| 1 | Is cardiac resynchronisation therapy feasible, safe and beneficial in the very elderly?显示文摘ObjectiveTo evaluate 心脏的同一时刻治疗(CRT ) 培植是否与经历 CRT 培植的 symptoms.MethodsConsecutive 病人一起在 octogenarians 和协会可行、安全,从二个英国中心被招募。根据年龄组织的病人:<80 &≥80 年。基线人口分布,复杂并发症和结果在 439 个病人的那些 groups.ResultsA 总数之间被比较在这研究, 26%≥ 是谁被包括;80 年。Octogenarians 更经常与心脏的同一时刻治疗使用高压脉冲来消减心脏相比收到了心脏的再同步治疗心律调整器。从心律调整器的升级在两个组是普通的(16%<80 年对 22%≥80 年, P = NS ) 。合作病态在两个组是同样普通的(全面糖尿病:25% , atrial 纤维性颤动:23% ,高血压:45%) 。更耐心的年龄 ≥80 年有重要的长期的肾疾病(CKD,估计的 glomerular 过滤率 <45 mL/min 每 1.73 m 2,44% 对 22% , P <0.01 ) 。全面复杂并发症率(任何东西) 在两个组是类似的(16% 对 17% , P = NS ) 。两个组表明了征兆的利益。一个年死亡率作为与更年轻的队相比是在 octogenarians 更大的几乎四褶层(13.9% 对 3.7% , P <0.01 ).ConclusionsCRT 看起来安全在尽管有广泛的合作病态老、特别地经常严重 CKD。征兆的改进看起来有意义。增加的策略是 CRT 的潜在的候选人的有 CHF 的老病人的适当鉴定被要求。 | Bartosz Olechowski Rebecca Sands Donah Zachariah Neil P Andrews Richard Balasubramaniam Mark Sopher John Paisey Paul R Kalra | 2015 | Journal of Geriatric Cardiology2015，12，5： | 5 |
| 2 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 3 | Efficacy and safety of low dose desmopressin orally disintegra- ti'ng tablet in women with nocturia: Results of a multi- center, randomized, double-blind, placebo controlled, parallel group study显示文摘 | Sand P K Dmoehowski R R Reddy J | 2013 | J Urol2013，190，3： | 1 |
| 4 | Crystallization of EU-1 and EU-2 in Alkali and Alkali-Free Systems显示文摘 | Dodwell G W Denkewicz R P Sand L B | 1985 | Zeolites1985，5，： | 1 |
| 5 | Postoperative delirium: the importance of pain and pain management显示文摘 | Linnea E Vaurio Laura P Sands Wang Yun | 2006 | Anesth Analg2006，102，4： | 1 |
| 6 | Generation of a stable packaging cell line producing high - titer PPT - deleted integration - deficient Ientiviral vectors显示文摘 | Hu P Li Y Sands MS | 2015 | Mol Ther Methods Clin Dev2015，，15： | 1 |
| 7 | The inhibitory role of nitric oxide in the control of porcine and human sphincter of Oddi activity显示文摘 | Sand J Arvola P Jentti V | 1997 | Gut1997，41，： | 1 |
| 8 | Evaluation of CHROMagar Candida for Presumptive Identification of Clinically Important Candida Species显示文摘 | Heather L Powell Crystal A Sand Robert P Rennie | 1998 | Diagn Microbiol Infect Dis1998，32，4： | 1 |
| 9 | Does fusion improve the outcome after decompressive surgery for lumbar spinal stenosis? A two-year follow-up study involving 5 390 patients显示文摘 | Forsth P Michaelsson K Sandén B | 2013 | J Bone Joint Surg Br2013，95，7： | 1 |
| 10 | Sulfur chemistry in bacterial of pyrite显示文摘 | SCHIPPERS A JOZSA P G SAND W | | 0，，09： | 1 |
| 11 | Fate of biuret 15N and its effect on net mineralisation of native soil n in forest soils 显示文摘 | XUE J M CLINTON P W SANDS R | 2008 | Australian Journal of Soil Research2008，46，： | 1 |
| 12 | Direct effect of thyroxine on pig sphincter of Oddi contractility显示文摘 | Inkinen J Sand J Arvola P | 2001 | Dig Dis Sci2001，46，1： | 1 |
| 13 | Prospective,randomized,double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder; results of the OPERA trial显示文摘 | Diokno A C Apell R A Sand P K | 2003 | Mayo Clin Proc2003，78，4： | 1 |
| 14 | Dexmedetomidine provides cortical neuroprotection:impact on anaesthetic-induced neuroapoptosis in the rat developing brain显示文摘 | Sande RD Sun P Patel S | 2010 | Acta Anaesthesiol Scand2010，54，6： | 1 |
| 15 | Effect of dialysate temperature on energy balance during hemodia- lysis: quantification of extracorporeal energy transfer 显示文摘 | VAN DER SANDE F M KOOMAN J P BUREMA J H | 1999 | Am J Kidney Dis1999，33，6： | 1 |
| 16 | ' Marine protected areas' off UK overseas territories : comparing the South Orkneys Shelf and the Chagos Archipelago显示文摘 | Sand P H | 2012 | The Geograph- ical Journal2012，178，3： | 1 |
| 17 | Vedolizumab as induction and maintenance therapy for ulcerative colitis显示文摘 | Feagan BG I:kutgeerts P Sands BE | 2013 | New England Journal of Medicine2013，369，8： | 1 |
| 18 | Minimally invasive surgery for treatment of focal axillary hyperhidrosis显示文摘 | Bechara FG Sand M Boorboor P | 2007 | Plast Reconstr Surg2007，120，6： | 1 |
| 19 | Short-term outcomes of laparoscopic total mesorectal excision following neoadjuvant cheemoradiotherapy显示文摘 | Denoya P Wang H Sands D | 2010 | Surg Endosc2010，24，4： | 1 |
| 20 | The influence of increasing dialysis treatment time and reducing dryweight on bloodpressure control in hemodialysis patients: a prospective study 显示文摘 | LuikAJ Sande FM Weideman P | 2001 | Am J Nephrol2001，21，6： | 1 |
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