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您的检索式：作者名="Samya Banerjee"
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| 1 | Perturbing tumor cell metabolism with a Ru(Ⅱ)photo-redox catalyst to reverse the multidrug resistance of lung cancer显示文摘The novel concept of enzyme photocatalysis has recently attracted much attention in developing anticancer therapy.However,the relationship between coenzyme depletion and cellular metabolomic changes has rarely been investigated.Herein,we report the rational design of a deep-red light-triggered bis-tridentate Ru(Ⅱ)photocatalyst(Ru3),which induces cell metabolism disorder to combat multidrug resistance.Ru3 exhibits promising multiple triplet excited states,a long lifetime,and high photocatalytic activity toward the coenzyme.Consequently,Ru3 shows high phototherapeutic activity(photo index=191–833)against diverse resistant(cisplatin,5-fluorouracil,or paclitaxel)lung cancer cells by inhibiting cellular peptide,lipid,and glycerophospholipid metabolism.We believe that cell metabolism inhibition by photo-redox catalysts is an effective form of therapeutics for drug-resistant cancer cells. | Siqi Wei Hui Liang Anyi Dao Yuzhen Xie Fengshu Cao Qingyan Ren Ashish Kumar Yadav Rajesh Kushwaha Arif Ali Mandal Samya Banerjee Pingyu Zhang Shaomin Ji Huaiyi Huang | 2023 | Science China Chemistry2023，66，5： | 1 |
| 2 | Sonodynamic cancer therapy by novel iridium-gold nanoassemblies显示文摘Metal-based compounds with excellent photo-physical properties show good photochemotherapeutic performance.But,low in-depth tissue penetration of light limits their effectivity for deeply buried tumors.Encouraged by the sonosensitizing ability of the traditional organic photosensitizers,here,we developed AuNPs@Ir1 as a sonosensitizer by hybridizing an organometallic Ir(Ⅲ) complex(Ir1) with ultrasmall gold nanoparticles(AuNPs) for efficient tumor sonodynamic therapy(SDT) for the first time.AuNPs@Ir1 rapidly entered the cancer cells,produced ^(1)O_(2),and catalytically oxidized NADH to NAD;under ultrasound(US)irradiation,thus resulted in cancer cells oncosis.Because of efficient passive retention in tumors post intravenous injection,AuNPs@Ir1 further efficiently inhibited the growth of tumors in-vivo under US stimulation without long-term toxicity to other organs.Overall,this work presents the excellent US triggered in-vitro and in-vivo anticancer profile of the novel AuNPs@Ir1.It is expected to increase the scope of SDT for metal-based anticancer drugs. | Jiayi Zhu Ai Ouyang Zhuanglin Shen Zhihao Pan Samya Banerjee Qianling Zhang Yantao Chen Pingyu Zhang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
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