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您的检索式：作者名="SamuelS.KOIDE"
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| 1 | Immunolocalization of Epidermal Growth Factor in Human Fetal, Adult and Cryptorchid Testes and Seminoma显示文摘EGF was localized in human fetal, adult and cryptorchid testis and seminoma using an immunohistochemical method. Leydig cells of adult testes stained intensely for EGF while those of fetal testes showed weak staining reaction. In addition, some spermatogonia and occasional peritubular myoid cells of adult testis stained positively. In cryptorchid testis, there were clusters of Leydig cells interspersed between seminiferous tubules with varying staining intensities. The number of positively stained cells in the cryptorchid testis were fewer than that in adult testes. The decrease in the number of Leydig cells producing EGF may account for the spermatogenesis arrest and infertility associated with this disorder.Intense staining of the cytoplasm of seminoma cells was observed, suggesting that the high production of EGF may be related to their invasive property. In conclusion, EGF is produced by human testis and Leydig cells are the principal source of this cytokine. | 孙亚平 严缘昌 张美兰 董琦 赵峰 SamuelS.Koide | 1997 | Journal of Reproduction and Contraception1997，8，1： | 0 |
| 2 | Characterization of rtSH3p13 gene encoding a development protein involved in vesicular traffic in spermiogenesis显示文摘A cDNA, designated as rtSH3p13, was isolated from a rat testis cDNA library. It consists of 1463 bp nuclear acids,which encodes a protein of 312 amino acids and was assigned the GenBank accession number AF227439. The deduced rtSH3p13 protein is a truncated isoform of SH3p13 as a result of mRNA alternative splicing. It is mainly expressed in the rat testis, detected in spermatids at the steps 8-19 of spermiogenesis, and found around the acrosome. During postnatal development, rtSH3p13 appears on day 18 and reaches maximum on day 60. Further experimental results suggested that rtSH3p13 forms a complex with activated epidermal growth factor receptor (EGFR) and interacts with synaptojanin I. Surprisingly, similar to SH3 domain, the V region of rtSH3p13 also inhibits endocytosis in CHO cells.Our results reveal a link between an rtSH3p13-synaptojanin-clathrin complex-mediated formation of pits and the process of spermiogenesis. | YuanQIAO JuXiangYANG XiaoDongZHANG YuLIU JianChaoZHANG ShuDongZONG ShiYingMIAO LinFangWANG SamuelS.KOIDE | 2004 | Cell Research2004，14，3： | 0 |
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