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| 1 | hsa-miR-29c and hsa-miR-135b differential expression aspotential biomarker of gastric carcinogenesis显示文摘AIM: To investigate the expression profiles of hsa-mi R-29 c and hsa-mi R-135 b in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. METHODS: The expression levels of hsa-mi R-29 c and hsa-mi R-135 b in normal gastric mucosa, non-atrophic chronic gastritis, intestinal metaplasia and intestinaltype gastric adenocarcinoma were analysed using quantitative real-time PCR. The difference between hsa-mi R-29 c and hsa-mi R-135 b expression profiles in the grouped samples was evaluated by ANOVA and Student's t-test tests. The results were adjusted for multiple testing by using Bonferroni's correction. P values ≤ 0.05 were considered statistically significant. To evaluate hsa-mi R-29 c and hsa-mi R-135 b expressions as potential biomarkers of gastric carcinogenesis, we performed a receiver operating characteristic curve analysis and the derived area under the curve, and a Categorical Principal Components Analysis. In silico identification of the genetic targets of hsa-mi R-29 c and hsa-mi R-135 b was performed using different prediction tools, in order to identify possible genes involved in gastric carcinogenesis.RESULTS: The expression levels of hsa-mi R-29 c were higher in normal gastric mucosal samples, and decreased progressively in non-atrophic chronic gastritis samples, intestinal metaplasia samples and intestinal-type gastric adenocarcinoma samples. The expression of hsa-mi R-29 c in the gastric lesions showed that non-atrophic gastritis have an intermediate profile to gastric normal mucosa and intestinal-type gastric adenocarcinoma, and that intestinal metaplasia samples presented an expression pattern similar to that in intestinal-type gastric adenocarcinoma. This micro RNA(mi RNA) has a good discriminatory accuracy between normal gastric samples and(1) intestinal-type gastric adenocarcinoma; and(2) intestinal metaplasia, and regulates the DMNT3 A oncogene. hsa-mi R-135 b is up-regulated in non-atrophic chronic gastritis and intestinal metaplasia samples and down-regulated in normal gastric mucosa and intestinal-type gastric adenocarcinoma samples. Non-atrophic chronic gastritis and intestinal metaplasia are significantly different from normal gastric mucosa samples. hsa-mi R-135 b expression presented a greater discriminatory accuracy between normal samples and gastric lesions. This mi RNA was associated with Helicobacter pylori presence in non-atrophic chronic gastritis samples and regulates the APC and KLF4 tumour suppressor genes.CONCLUSION: Our results provide evidence of epigenetic alterations in non-atrophic chronic gastritis and intestinal metaplasia and suggest that hsa-mi R-29 c and hsa-mi R-135 b are promising biomarkers of gastric carcinogenesis. | Amanda Ferreira Vidal Aline MP Cruz Leandro Magalhães Adenilson L Pereira Ana KM Anaissi Nélisson CF Alves Paulo JBS Albuquerque Rommel MR Burbano Samia Demachki Ândrea Ribeiro-dos-Santos | 2016 | World Journal of Gastroenterology2016，22，6： | 7 |
| 2 | Crystallization and properties of glasses based on diopside-Ca-Tschermak's-fluorapatite system显示文摘 | Samia N Salama H | 2005 | Journal of the European Ceramic Society2005，25，7： | 1 |
| 3 | Uptake of copper ions by carbon fiber/polymer hybrids prepared by tandem diazonium salt chemistry and in situ atom transfer radical polymerization 显示文摘 | Samia M C Abbas N Matrab T | 2010 | Carbon2010，48，7： | 1 |
| 4 | Crystallization and properties of glasses based on diopside-Ca-Tschermak' s-fluorapatite system 显示文摘 | Samia N Salama Darwish H Abo-Mosallam H A | 2005 | Journal of the European Ceramic Society2005，25，7： | 1 |
| 5 | The effect of irriaation with drainage w~ter on some chemical soil properties and the yield of different field crops显示文摘 | Samia E G Gamal A E N Attiat A B | 1987 | CIHEAM - Options Mediterraneennes1987，1，： | 1 |
| 6 | Contribution of germanium dioxide to the thermal expansion characteristeics of some borosilicate glasses and their corresponding glass-ceramics显示文摘 | DARWISH H SAMIA N SALMAN S M | 2001 | Thermochim Acta2001，374，： | 1 |
| 7 | Treatment of Arterial Lesions in Drug Addicts显示文摘 | Devecioglu M Settembre N Samia Z | 2014 | Ann Vasc Surg2014，28，1： | 1 |
| 8 | Changes in rainfall partitioning caused by the replacement of native dry forests of Lithraea molleoides by exotic plantations of Pinus elliottii in the dry Chaco mountain forests, central Argentina显示文摘The replacement of native dry forests by commercial(exotic)tree plantations could generate changes in rainfall partitioning,which further affects the water cycle.In this study,we determined(i)the rainfall partitioning into interception,throughfall and stemflow,(ii)the role of rainfall event size on rainfall partitioning,(iii)the pH of water channelized as throughfall and stemflow,and(iv)the runoff in Lithraea molleoides(a native species)and Pinus elliottii(an exotic species)stands in the dry Chaco mountain forests,central Argentina.On average,interception,throughfall and stemflow accounted for 19.3%,79.5%and 1.2%of the gross rainfall in L.molleoides stand,and 32.6%,66.7%and 0.7%of the gross rainfall in P.elliottii stand,respectively.Amounts of interception,throughfall and stemflow presented positive linear relationships with the increment of rainfall event size for both tree species(P<0.01 in all cases).Percentages of interception,throughfall and stemflow were all related to the increment of rainfall event size,showing different patterns.With increasing rainfall event size,interception exponentially decreased,throughfall asymptotically increased and stemflow linearly increased.Both P.elliottii and L.molleoides stands presented significant differences in the pH values of water channelized as throughfall(6.3 vs.6.7,respectively;P<0.01)and stemflow(4.5 vs.5.8,respectively;P<0.01).Runoff occupied only 0.3%of the gross rainfall in P.elliottii stand and was zero in L.molleoides stand.Our results showed that the native species L.molleoides presented 13.6%more water reaching the topsoil(i.e.,net rainfall;net rainfall=gross rainfall-interception-runoff)than the exotic species P.elliottii.This study improves our understanding of the effects of native vegetation replacement on the local water balance in the dry forest ecosystems. | Samia S CORTÉS Juan I WHITWORTH-HULSE Eduardo L PIOVANO Diego E GURVICH Patricio N MAGLIANO | 2020 | Journal of Arid Land2020，12，5： | 0 |
| 9 | Adsorption of rare earth elements onto diatomite M45:Experimental investigations and modeling with statistical physics theory显示文摘The separation of rare earth elements using diatomite M45 from aqueous solutions was studied.The experimental isotherms for the adsorption of trivalent lanthanum,cerium,and neodymium cations on this adsorbent were quantified under strongly acidic conditions(pH 2)at 298-328 K.The adsorption equilibria of these earth elements were analyzed using two statistical physics models(homogeneous and heterogeneous monolayer models).The results show that the adsorption of these ions implies a multiionic mechanism,which is exothermic.Si-containing functional groups are responsible for the adsorption of these rare-earth elements on the diatomite surface.A heterogeneous statistical physics model confirms that two Si-based functional groups participate in the separation of these cations.The calculated adsorption capacities at saturation follow the order:neodymium>cerium>lanthanum.Calculated interaction energies range from 28600 to 40100 J/mol,indicating physical adsorption on diatomite M45.This study demonstrates that diatomite M45 is a promising separation medium that can be used for the recovery of REEs dissolved in aqueous solutions via adsorption. | Fatma Dhaouadi Guilherme L.Dotto Julien Vieillard Diana Pinto Luis F.O.Silva Éder C.Lima Mu Naushad Fatma Aouaini Samia Nasr Adrián Bonilla-Petriciolet Abdelmottaleb Ben Lamine | 2023 | Journal of Rare Earths2023，41，11： | 0 |
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