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| 1 | Effects of iodinated contrast on various magnetic resonance imaging sequences and field strength: Implications for characterization of hemorrhagic transformation in acute stroke therapy显示文摘AIM: To characterize the effects of iodinated contrast material(ICM) on magnetic resonance imaging(MRI) comparing different sequences and magnetic fields, with emphasis to similarities/differences with well-known signal characteristics of hemorrhage in the brain. METHODS: Aliquots of iopamidol and iodixanol mixed with normal saline were scanned at 1.5T and 3T. Signal intensity(SI) was measured using similar spin-echo(SE)-T1, SE-T2, gradient-echo(GRE) and fluid-attenuationinversion-recovery(FLAIR) sequences at both magnets. Contrast to noise ratio(CNR)(SI contrast-SI saline/SD noise) for each aliquot were calculated and Kruskall-wallis test and graphic analysis was used to compare different pulse sequences and ICMs. RESULTS: Both ICM showed increased SI on SE-T1 and decreased SI on SE-T2, GRE and FLAIR at both 1.5T and 3T, as the concentration was increased. By CNR measurements, SE-T2 had the greatest conspicuity at 3T with undiluted iopamidol(92.6 ± 0.3, P < 0.00) followed by iodixanol(77.5 ± 0.9, P < 0.00) as compared with other sequences(CNR range: 15-40). While SE-T2 had greatest conspicuity at 1.5T with iopamidol(49.3 ± 1, P < 0.01), SE-T1 showed similar or slightly better conspicuity(20.8 ± 4) than SE-T2 with iodixanol(23 ± 1.7). In all cases, hypo-intensity on GRE was less conspicuous than on SE-T2.CONCLUSION: Iodixanol and iopamidol shorten T1 and T2 relaxation times at both 1.5T and 3T. Hypo-intensity due to shortened T2 relaxation time is significantly more conspicuous than signal changes on T1-WI, FLAIR or GRE. Variations in signal conspicuity according to pulse sequence and to type of ICM are exaggerated at 3T. We postulate T2 hypointensity with less GRE conspicuity differentiates ICM from hemorrhage; given the wellknown GRE hypointensity of hemorrhage. Described signal changes may be relevant in the setting of recent intra-arterial or intravenous ICM administration in translational research and/or human stroke therapy. | Humberto Morales Lisa Lemen Ranasinghage Samaratunga Peter Nguyen Thomas Tomsick | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 2 | Expression of the disintegrin metalloprotease, ADAM- 10, in prostate cancer and its regulation by dihydrotestosterone, insulin- like growth factor I, and epidermal growth factor in the pros- tate cancer cell model LNCaP 显示文摘 | Mcculloch DR Aki P Samaratunga H | 2004 | Clin Cancer Res2004，10，1： | 1 |
| 3 | Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP 显示文摘 | McCulloch DR Akl P Samaratunga H | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 4 | Distribution patten of basal cells detcted by cytokeratin 34beta E 12 in primaty prostate duct adenocatcinosa 显示文摘 | Samaratunga H Singh M | 1997 | Am J Surgpathol1997，21，4： | 1 |
| 5 | Distribution pattern of basal cel is detcted by cytokeratin 34beta E12 in primaty prostate duct adenocatcinosa 显示文摘 | Samaratunga H Singh M | 1997 | Am J Surg Pathol1997，21，4： | 1 |
| 6 | Ductal adenocarcinoma of the prostate:current opinion and controversies显示文摘 | Samaratunga H Delahunt B | 2008 | Anal Quant Cytol Histol2008，30，4： | 1 |
| 7 | What is the molecular pathology of low-risk prostate cancer?显示文摘 | Hemamali Samaratunga Jonathan I. Epstein | 2008 | World Journal of Urology2008，，5： | 1 |
| 8 | Micropapillary variant of urothelial carcinoma of the urinary bladder: a clinicopathological and immunohistochemical study显示文摘 | Samaratunga H Khoo K | 2004 | Histopathology2004，45，： | 1 |
| 9 | Micropapillary variant of urothelial car- cinoma of the urinary bladder; adinico pathological and immuno- histo chemical study显示文摘 | Samaratunga H Khoo K | 2004 | Histopathology2004，45，1： | 1 |
| 10 | Ductal adenocarcinoma of the pro- state:current opinion and Controversies显示文摘 | Samaratunga H Delahunt B | 2008 | Anal Quant Cytol His- tol2008，30，4： | 1 |
| 11 | Cellular angiofibroma of the scrotum显示文摘 | Samaratunga H Fitzpatrick P | 2008 | Pathology2008，40，3： | 1 |
| 12 | Wave propagation analysis in adhesively bonded composite joints using the wavelet spectral finite element method显示文摘 | Samaratunga D Jha R Gopalakrishnan S | 2015 | Composite Structures2015，122，： | 1 |
| 13 | Cancer stem cell mark- ers in prostate cancer: an study of ALDH1, SOX2 and EZH2 显示文摘 | Matsika A Srinivasan B Samaratunga H | 2015 | Pathology2015，47，7： | 1 |
| 14 | Comparison of WHO/ISUP and WHO classification of nonlnvasive papillary urothellal neoplasms for risk of progression 显示文摘 | Samaratunga H Makarov DV Epstein JI | 2002 | Urology2002，60，2： | 1 |
| 15 | Micropapillary variant of urothelial carcinoma of the urinary bladder; a clinicopathological and immunohistochemical study显示文摘 | Samaratunga H Khoo K | 2004 | Histopathology2004，45，1： | 1 |
| 16 | Atypical presentation of herpes simplex (chronicresistant mucocutaneous herpes simplex infec- tions in AIDS patients: a clinical and virological challenge 显示文摘 | Samaratunga H Weedon D Musgrave N | 2011 | HIV Med2011，12，6： | 1 |
| 17 | Any proportion of ductal adenocarcinoma in radical prostatectomy specimens predicts extraprostatic extension 显示文摘 | Samaratunga H Duffy D Yaxley J | 2010 | Hum Pathol2010，41，2： | 1 |
| 18 | Localization of N-acetyltransferases NAT1 and NAT2 in human tissues显示文摘 | Windmill KF Gaedigk A Hall PM Samaratunga H Grant DM McManus ME | 2000 | Toxicol Sci2000，54，1： | 1 |
| 19 | Diuretic activity of Spilanthes acmella flowers in rats显示文摘 | W.D Ratnasooriya K.P.P Pieris U Samaratunga J.R.A.C Jayakody | 2004 | Journal of Ethnopharmacology2004，，2： | 1 |
| 20 | Identifica- tion of claudin -4 as a marker highly overexpressed in both prima- ry and metastatic prostate cancer显示文摘 | LANDERS K A SAMARATUNGA H TENG L | 2008 | Br J Cancer2008，99，3： | 1 |
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