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| 1 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 2 | Changes in rat testicular antioxidant defence profile as a function of age and its impairmen by hexachlorocyclohexane during critical stages of maturation显示文摘 | Samanta L Roy A Chainy G B | 1999 | Andrologia1999，31，1： | 1 |
| 3 | Human cytomegalovirus infection and expression in human malignant gliomal显示文摘 | Cobbs CS Harkins L Samanta G | 2002 | Cancer Res2002，62，12： | 1 |
| 4 | Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer显示文摘 | Harkins L Volk AL Samanta M | | 0，，9345： | 1 |
| 5 | Three-dimensional plasma particle-in-cell calculations of ion thruster backflow contamination显示文摘 | Samanta Roy R L Hastings D E Taylor S | 1996 | Journal of Computational Physics1996，128，1： | 1 |
| 6 | Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer显示文摘 | Harkins L Volk AL Samanta M | 2002 | Lancet2002，360，9345： | 1 |
| 7 | Oxidative stress and heart failure in altered thy- roid states显示文摘 | Mishra P Samanta L | 2012 | The scientific World Journal2012，，： | 1 |
| 8 | Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer 显示文摘 | Harkins L Volk AL Samanta M | 2002 | Lancet2002，360，9345： | 1 |
| 9 | Mechanosynthesisof nanocrystalline CuFeS2 chalcopyrite 显示文摘 | PRADHAN S K GHOSH B SAMANTA L K | 2006 | Physica E2006，33，： | 1 |
| 10 | On the linear, nonlinear, and optoelectronic properties of some multinary compound semiconductors显示文摘 | CHATTEDJEE S | 1994 | Physica Status Solidi(b)1994，182，1： | 1 |
| 11 | Human cytomegalovirus infection and expression in human malignant gliomal 显示文摘 | Cobbs CS Harkins L Samanta G | 2002 | Cancer Res2002，62，12： | 1 |
| 12 | 显示文摘 | Samanta P Chen C L Lee Y J | 2009 | J Appl Phys2009，105，12： | 1 |
| 13 | Update on biologic therapies in ankylosing spondylitis:a literature review显示文摘 | Goh L Samanta A | 2012 | Int J Rheum Dis2012，15，5： | 1 |
| 14 | Oxidative stress and heart failure in altered thyroid States显示文摘 | Mishra P Samanta L | 2012 | Scientific World Journal2012，，74： | 1 |
| 15 | Testost-erone-induced changes in testieular antioxidant system 显示文摘 | Chainy G Samantaray S Samanta L | 1997 | Andrologia1997，29，6： | 1 |
| 16 | Changes in rat testicular an-tioxidant defence profile as a function of age and its impair-ment by hexachlorocyclohexane during critical stages of mat-uration 显示文摘 | Samanta L Roy A Chainy GB | 1999 | Andrologia1999，31，2： | 1 |
| 17 | Specific localization of human cytomegalovirus nucleic acids and proteins in human colorectal cancer显示文摘 | Harkins L Volk AL Samanta M | 2002 | Lancet2002，360，9345： | 1 |
| 18 | High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma显示文摘 | Samanta M Harkins L Klemm K | 2003 | J Urol2003，170，3： | 1 |
| 19 | Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3显示文摘 | Iwakiri D Zhou L Samanta M | | 0，，10： | 1 |
| 20 | Human cytomegalovirus infection and expression in human malignant glioma显示文摘 | Cobbs CS Harkins L Samanta M | 2002 | Cancer Res2002，62，12： | 1 |
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