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| 1 | Biochemical changes in the injured brain显示文摘Brain metabolism is an energy intensive phenomenon involving a wide spectrum of chemical intermediaries. Various injury states have a detrimental effect on the biochemical processes involved in the homeostatic and electrophysiological properties of the brain. The biochemical markers of brain injury are a recent addition in the armamentarium of neuro-clinicians and are being increasingly used in the routine management of neuropathological entities such as traumatic brain injury, stroke, subarachnoid haemorrhage and intracranial space occupying lesions. These markers are increasingly being used in assessing severity as well as in predicting the prognostic course of neuro-pathological lesions. S-100 protein, neuron specific enolase, creatinine phosphokinase isoenzyme BB and myelin basic protein are some of the biochemical markers which have been proven to have prognostic and clinical value in the brain injury. While S-100, glial fibrillary acidic protein and ubiquitin C terminal hydrolase are early biomarkers of neuronal injury and have the potential to aid in clinical decisionmaking in the initial management of patients presenting with an acute neuronal crisis, the other biomarkers are of value in predicting long-term complications and prognosis in such patients. In recent times cerebral microdialysis has established itself as a novel way of monitoring brain tissue biochemical metabolites such as glucose, lactate, pyruvate, glutamate and glycerol while small non-coding RNAs have presented themselves as potential markers of brain injury for future. | Seelora Sahu Deb Sanjay Nag Amlan Swain Devi Prasad Samaddar | 2017 | World Journal of Biological Chemistry2017，8，1： | 22 |
| 2 | Adjuvants to local anesthetics: Current understanding and future trends显示文摘Although beneficial in acute and chronic pain management, the use of local anaesthetics is limited by itsduration of action and the dose dependent adverse effects on the cardiac and central nervous system. Adjuvants or additives are often used with local anaesthetics for its synergistic effect by prolonging the duration of sensory-motor block and limiting the cumulative dose requirement of local anaesthetics. The armamentarium of local anesthetic adjuvants have evolved over time from classical opioids to a wide array of drugs spanning several groups and varying mechanisms of action. A large array of opioids ranging from morphine, fentanyl and sufentanyl to hydromorphone, buprenorphine and tramadol has been used with varying success. However, their use has been limited by their adverse effect like respiratory depression, nausea, vomiting and pruritus, especially with its neuraxial use. Epinephrine potentiates the local anesthetics by its antinociceptive properties mediated by alpha-2 adrenoreceptor activation along with its vasoconstrictive properties limiting the systemic absorption of local anesthetics. Alpha 2 adrenoreceptor antagonists like clonidine and dexmedetomidine are one of the most widely used class of local anesthetic adjuvants. Other drugs like steroids(dexamethasone), anti-inflammatory agents(parecoxib and lornoxicam), midazolam, ketamine, magnesium sulfate and neostigmine have also been used with mixed success. The concern regarding the safety profile of these adjuvants is due to its potential neurotoxicity and neurological complications which necessitate further research in this direction. Current research is directed towards a search for agents and techniques which would prolong local anaesthetic action without its deleterious effects. This includes novel approaches like use of charged molecules to produce local anaesthetic action(tonicaine and n butyl tetracaine), new age delivery mechanisms for prolonged bioavailability(liposomal, microspheres and cyclodextrin systems) and further studies with other drugs(adenosine, neuromuscular blockers, dextrans). | Amlan Swain Deb Sanjay Nag Seelora Sahu Devi Prasad Samaddar | 2017 | World Journal of Clinical Cases2017，5，8： | 18 |
| 3 | Vasopressors in obstetric anesthesia: A current perspective显示文摘Vasopressors are routinely used to counteract hypotension after neuraxial anesthesia in Obstetrics. The understanding of the mechanism of hypotension and the choice of vasopressor has evolved over the years to a point where phenylephrine has become the preferred vasopressor. Due to the absence of definitive evidence showing absolute clinical benefit of one over the other, especially in emergency and high-risk Cesarean sections, our choice of phenylephrine over the other vasopressors like mephentermine, metaraminol, and ephedrine is guided by indirect evidence on fetalacid-base status. This review article evaluates the present day evidence on the various vasopressors used in obstetric anesthesia today. | Deb Sanjay Nag Devi Prasad Samaddar Abhishek Chatterjee Himanshu Kumar Ankur Dembla | 2015 | World Journal of Clinical Cases2015，3，1： | 15 |
| 4 | Comparative analysis of APACHE-Ⅱ and P-POSSUM scoring systems in predicting postoperative mortality in patients undergoing emergency laparotomy显示文摘BACKGROUND Laparotomy remains one of the commonest emergency surgical procedures.Early prognostic evaluation would aid in selecting the high-risk patients for an aggressive treatment.Awareness about risks could potentially contribute to the quality of perioperative care and optimum utilization of resources.Portsmouth modification of Physiological and operative severity for the enumeration of mortality and morbidity (P-POSSUM) and the acute physiology and chronic health evaluation Ⅱ(APACHE-Ⅱ) have been the most widely used scoring systems for emergency laparotomies.It is always better to have a single scoring system to predict outcomes and audit healthcare organizations.AIM To compare the ability of APACHE-II and P-POSSUM to predict postoperative morbidity and mortality in patients undergoing emergency laparotomy.METHODS All patients undergoing emergency laparotomy at the Tata Main Hospital,Jamshedpur between December 2013 and November 2014 were included in the study.In this observational study,P-POSSUM and APACHE-Ⅱ scoring were done,and the outcome analysis evaluated with mortality being the primary outcome.RESULTS For P-POSSUM,at a cut off value of 63 to predict mortality using receiver operating characteristics curve analysis,the area under the curve was 0.989;and for APACHE-Ⅱ,at the cut off value of 24,the area under the curve was 0.965.CONCLUSION Because the ability of APACHE-Ⅱ to predict mortality was similar to P-POSSUM and APACHE-Ⅱ does not need scoring for intra-operative findings and histopathology reports,APACHE-Ⅱ can be used pre-operatively to assess the risk in patients undergoing emergency laparotomy.However,for audit purposes,either of the two scoring systems can be used. | Deb Sanjay Nag Ankur Dembla Pratap Rudra Mahanty Shashi Kant Abhishek Chatterjee Devi Prasad Samaddar Parul Chugh | 2019 | World Journal of Clinical Cases2019，7，16： | 5 |
| 5 | 美洲远志根提取物对苯并芘致肺癌小鼠的抗肿瘤作用(英文)显示文摘目的:研究美洲远志(Polygala senega)根的乙醇提取物对苯并芘致肺癌小鼠的抗肿瘤作用。方法:瑞士白化小鼠被分为5组,每组6只。组1为对照组,予口服橄榄油;组2予苯并芘(50mg/kg体质量,溶于橄榄油中),每周2次,连续4周;组3除予与组2相同的苯并芘外,再予48%乙醇;组4予与组2相同的苯并芘,并同时给予美洲远志的乙醇提取物,每日1次,连续16周;组5仅给予美洲远志的乙醇提取物,每日1次,连续16周。16周后,处死所有小鼠并检测和评价以下指标:2,2-二苯基-1-苦基肼(2,2-diphenyl-1-picrylhydrazyl,DPPH)法测定美洲远志乙醇提取物的抗氧化功效;分别称取各组小鼠的肺组织质量及体质量;彗星实验及酶联免疫吸附法检测DNA损伤情况;分别测定过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、脂质过氧化反应及总含硫化合物含量。结果:给予美洲远志乙醇提取物治疗的组4小鼠与组3模型组小鼠相比,体质量明显增加而肺组织质量明显降低(P<0.01)。彗星实验结果显示组4小鼠的DNA损伤较组3小鼠明显减轻(P<0.01)。酶联免疫吸附法测定p53蛋白水平,组4明显高于组3(P<0.01)。组2和组3的模型小鼠与组1比较,脂质过氧化反应水平明显升高,而抗氧化标志物的水平明显降低(P<0.05),组4小鼠的这些指标被明显逆转(P<0.01)。结论:美洲远志对于化学制剂致小鼠肺癌有明确的治疗效果。 | Saili Paul Soumya Sundar Bhattacharyya Asmita Samaddar Naoual Boujedaini Anisur Rahman Khuda-Bukhsh | 2011 | 中西医结合学报2011，9，3： | 4 |
| 6 | An analysis of inter organizational resource sharing decisions in collaborative knowledge creation显示文摘 | Samaddar S Kadilyala S | 2006 | European Journal of Operational Research2006，170，1： | 1 |
| 7 | An analysis of interorganizatimal resource sharing decisions in collaborative knowledge creation 显示文摘 | Samaddar S Kadiyala S | 2006 | European Journal of Operational Research2006，170，： | 1 |
| 8 | Mercuric ion stabilizes levansucrase secreted byAcetobacter nitrogenifigens strain RG1T 显示文摘 | Paul A Samaddar N Dutta D Baqchi A Chakravorty S ChakrabortyW Gachhui R | 2011 | Protein J2011，30，4： | 1 |
| 9 | Downregulation of retinoblas- toma protein is involved in the enhanced cytotoxicity of 4-hydroxytamox- ifen plus mifepristone combination therapy versus antiestrogen monothera- py of human breast caneer显示文摘 | Schoenlein PV Hou M Samaddar JS | 2007 | Int J Oncol2007，31，3： | 1 |
| 10 | An Analysis of Interorganizational Resource Sharing Decisions in Collaborative Knowledge Creation 显示文摘 | SAMADDAR S KADIYALA S | 2006 | European Journal of Operational Research2006，，170： | 1 |
| 11 | Increased muscle mass with myostatin deficiency improves gains in bone strength with exercise显示文摘 | Hamrick M W Samaddar T Pennington C | 2006 | J Bone Miner Res2006，21，3： | 1 |
| 12 | An analysis of inter-organizational resource sharing decisions in collaborative knowledge creation显示文摘 | Samaddar S Kadilyala S | | 0，，01： | 1 |
| 13 | Neuroprotective effect of a triterpenoid saponin isolated from Momordica cymbalaria Fenzl in diabetic peripheral neuropathy显示文摘 | KoneriRB SamaddarS SimiS | 2014 | Indian journal of pharmacology2014，46，1： | 1 |
| 14 | An analysis of interorganizational resource sharing decisions in collaborative knowledge creation 显示文摘 | Samaddar S Kadiyala S S | 2006 | European Journal of Operational Research2006，170，1： | 1 |
| 15 | Uroproteetive effect of a triterpenoid saponin isolated from m omordica cym balaria fenzl in diabetic peripheral neuropathy显示文摘 | Koneri RB Samaddar S Simi S el al | 2014 | Indian J Pharmacol2014，46，1： | 1 |
| 16 | An Analysis of Interorganizational Resource Sharing Decisions in Collaborative Knowledge Creation显示文摘 | Samaddar S Kadiyala S | 2006 | European Journal of Operational Research2006，170，1： | 1 |
| 17 | The theory of Loran-C ground wave propagation-a review显示文摘 | SAMADDAR S N | 1979 | Navigation the Journal of The US Institute of Navigation1979，26，3： | 1 |
| 18 | Amide side chain amphiphi- lic polymers disrupt surface established bacteria] bio-films and pro- tect mice from chronic Acinetobacter baumannii infection显示文摘 | Uppu DS Samaddar S Ghosh C | 2015 | Bio- materials2015，74，9： | 1 |
| 19 | Asymmetric reduction of aminoketones with (-)-bornan-2-exo-yloxyalumium dichloride 显示文摘 | Samaddar A K Konar S K Nasipuri D | 1983 | J Chem Soc Perkin Trans I1983，，7： | 1 |
| 20 | Dynamics of Mycobacte- riophage-mycobacterial host interaction: evidence for secondary mechanisms for host lethality显示文摘 | Samaddar S Grewal RK Sinha S | 2015 | Appl Environ Microbiol2015，82，1： | 1 |
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