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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 3 | Endoscopic palliation of malignant biliary stricture显示文摘Malignant biliary strictures often present late after the window for curative resection has elapsed. In such patients, the goal of therapy is typically focused on palliation. While historically, palliative measures were performed surgically, the advent of endoscopic intervention offers minimally invasive options to provide relief of symptoms, improve quality of life, and in some cases, increase survival of these patients. Some of these therapies, such as endoscopic biliary decompression, have become mainstays of treatment for decades, whereas newer modalities, including radiofrequency ablation, and photodynamic therapy offer additional options for patients with incurable biliary malignancies. | Sanjay M Salgado Monica Gaidhane Michel Kahaleh | 2016 | World Journal of Gastrointestinal Oncology2016，8，3： | 3 |
| 4 | Evaluation of a three- dimensional method of slope stability analysis 显示文摘 | Hungr O Salgado F M Byrne P M | 1989 | Canadian Geotechnical Journal1989，26，： | 1 |
| 5 | Cavity expansion and penetration resistance in sand 显示文摘 | Salgado R Mitchell J K Jamiolkowski M | 1997 | J Geotech Geoenvir Engrg1997，123，4： | 1 |
| 6 | Effect offunctionalized carbon as Pt electrocatalyst support on themethanol oxidation reaction显示文摘 | Salgado J R C Duarte D G Ilharco L M | 2011 | Applied Catalysis B: En-vironmental2011，102，： | 1 |
| 7 | Comparison of Soxhlet, accelerated solvent and supercfitical fluid extraction techniques for volatile (GC-MS and GC/FID) and phenolic compounds (HPLC-ESI/MS/MS) from Lamiaceae species 显示文摘 | RODR~GUEZ-SOLANA R SALGADO J M DOMfNGUEZ J M | 2015 | Phytochem Analysis2015，26，1： | 1 |
| 8 | Evaluation of a three dimensional method of slope-stability analysis显示文摘 | HUNGR O SALGADO F M BYRNE P M | 1989 | Canadian Geoteehnieal Journal1989，26，： | 1 |
| 9 | Evaluation of a Three-Dimensional Method of Slope-Stability Analysis 显示文摘 | Hungr O Salgado F M Byrne P M | 1989 | Canadian Geotechnical Journal1989，26，3： | 1 |
| 10 | The value of Cockcroft-Gault equation for the screening of decreased renal function in patients w ith systemic arterial hypertension显示文摘 | Santos E M Franca A K Salgado J V | 2011 | J Bras Nefrol2011，33，3： | 1 |
| 11 | A summary of the report on survey of controls and control performance in HVDC schemes显示文摘 | Szechtman M Ping W W Salgado E | 1994 | Electra1994，，155： | 1 |
| 12 | Risk factors associated to retinopathy of prematurity 显示文摘 | Zamorano Jimenez CA Salgado Valladares M Velasquez Vaiassi B | 2012 | Gac MedMex2012，148，1： | 1 |
| 13 | Low-loss splice in a microstructured fibre using a conventional fusion splicer显示文摘 | FRAZAO O CARVALHO J P SALGADO H M | 2005 | Microwave and Optical Technology Letters2005，46，2： | 1 |
| 14 | Transmission loss allocation through a modified Y-bus显示文摘 | Daniel J S Salgado R S Irving M R | 2005 | lEE Proceedings-Generation Transmission andDistribution2005，152，2： | 1 |
| 15 | Ec- topic ACTH syndrome:our experience with 25 cases 显示文摘 | Salgado LR Fragoso MC Knoepfelmacher M | 2006 | Eur J Endocrinol2006，155，5： | 1 |
| 16 | Recovery of zinc and manganese from spent alkaline batteries by liquid-liquid extraction with Cyanex 272 显示文摘 | Salgado A L Veloso A M O Pereira D D | 2003 | Journal of Power Sources2003，115，： | 1 |
| 17 | Evaluation of a Three-dimensional Method of Slope Stability Analysis 显示文摘 | Hunger O Salgado F M Byme P M | 1989 | Canadian Geotechnical Journal1989，26，： | 1 |
| 18 | A novel alternatively spliced transcript of cytosolic alanine aminotransferase gene associated with enhanced gluconeogenesis in liver of Sparus aurata 显示文摘 | Anemaet I G Met6n I Salgado M C | 2008 | The International Journal of Biochemistry & CelIBiology2008，40，12： | 1 |
| 19 | Purification and substrate specificity of an angiotensin coverting elas- tase-2 from the rat mesenteric arterial bed perfusate显示文摘 | PAULA C A SOUSA M V SALGADO M C | 1998 | Biochimaica et Biophysica Acta1998，1338，1： | 1 |
| 20 | Settlement analysis of piles with rectangular cross sections in multilayered soil 显示文摘 | Basu D Prezzi M Salgado R | 2008 | Computers and Geotechnics2008，，35： | 1 |
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