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| 1 | Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy显示文摘AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of patients.CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma. | Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，1： | 6 |
| 2 | Base-metal electrode capacitors显示文摘 | Yukio Sakabe Tom Reynolds | 2002 | Am Ceram Soc Bull2002，81，10： | 2 |
| 3 | Influ- ence of Ba/Ti ratio on the positive temperature coeffi- cient of resistivity characteristics of Ca-doped semi- :onducting BaTiOa firedin reducing atmosphere and reoxidized in air显示文摘 | Hideaki Niimi Kenjiro Mihara Yukio Sakabe | 2007 | Journal of the American Ceramic Society2007，90，6： | 1 |
| 4 | Expression of toll-like receptor 2,nod2 and dectin-1 and stimulatory effects of their ligands and histamine in normal human keratinocytes显示文摘 | Kobayashi M Yoshiki R Sakabe J Kabashima K Nakamura M 15.Tokura Y | | British Journal of Dermatology0，，： | 1 |
| 5 | Hemoglobin in- duces the expression of indoleamine 2, 3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-KB and the generation of reactive oxygen species显示文摘 | Ogasawara N Oguro T Sakabe T | 2009 | J Cell Biochem2009，108，3： | 1 |
| 6 | Dendritic cell-based im- munotherapy targeting synthesized peptides for advanced bili- ary tract cancer 显示文摘 | Kobayashi M Sakabe T Abe H | 2013 | J Gastrointest Surg2013，17，9： | 1 |
| 7 | Model-dependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123)on experimental atrial fibrillation in dogs显示文摘 | Shiroshita-Takeshita A Sakabe M Haugan K | 2007 | Circulation2007，115，： | 1 |
| 8 | CTdata- base : a knowledge-base of high-throughput and curated da- ta on cancer-testis antigens显示文摘 | Ahneida LG Sakabe N J deOliveira AR | 2009 | Nucleic Acids Res2009，37，： | 1 |
| 9 | Dielectric materials for base-metal multiplayer ceramic capacitors 显示文摘 | SAKABE Y | 1987 | Am Ceram Soe Bull1987，66，9： | 1 |
| 10 | Modeldependent effects of the gap junction conduction-enhancing antiarrhythmic peptide rotigaptide (ZP123) on experimental atrial fibrillation in dogs显示文摘 | Sakabe M Haugan K | 2007 | Circulation2007，115，3： | 1 |
| 11 | Inhibitory effect of natural and environmental estrogenson thymic hormone production in thymus epithelial cell culture显示文摘 | Sakabe K Okuma M Karaki S | 1999 | Int J Immunopharmacol1999，21，12： | 1 |
| 12 | Cold spring harbor symposia on quantitative biology显示文摘 | OKAZAKI R OKAZAKI T SAKABE K | 1968 | Proc Natl Acad Sci USA1968，33，： | 1 |
| 13 | Evaluation of Temporo- mandibular Disorders in children Using Limited Cone-beam Com- puted Tomography: a case report 显示文摘 | Sakabe R Sakabe J Kuroki Y | 2006 | J Clin Pediatr Dent2006，31，1： | 1 |
| 14 | Role of SCC-S2 in experimental metastasis and modulation of VEGFR- 2,MMP- 1 ,and MMP- 9 expression显示文摘 | Zhang CB Chakravarty D Sakabe I | 2006 | Mol Ther2006，13，5： | 1 |
| 15 | Quantititive estimates of arc stability for C02 gasshielded arc welding显示文摘 | Mita T Sakabe | 1988 | Welding International1988，，2： | 1 |
| 16 | Life expectancy and functional prognosis after femoral neck fractures in hemodialysis patiems显示文摘 | Sakabe T Imai R Murata H | 2006 | J Orthop Trauma2006，20，5： | 1 |
| 17 | Over expression of GRP7$ protects glial cells from endoplasmic reticulumstress显示文摘 | Suyama K Watanabe M Sakabe K | 2011 | Neurosci Lett2011，504，： | 1 |
| 18 | Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia 显示文摘 | Sakabe M Shiroshita-Takeshita A Maguy A | 2008 | Cardiovasc Res2008，78，1： | 1 |
| 19 | High prevalence of cyclical variation in heart rate before nocturnal episodes of paroxysmal atrial fibrillation 显示文摘 | Fujiki A Sakabe M Yoshioka R | 2013 | Intern Med2013，52，19： | 1 |
| 20 | Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro显示文摘 | Tanimukai S Kimura T Sakabe H | 1997 | Exp Hematol1997，25，10： | 1 |
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