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| 1 | Saponins from Roots of Panax notoginseng显示文摘Objective To study the chemical constituents in the dried roots of Panax notoginseng.Methods The constituents were isolated and purified with chromatographic methods.Their structures were elucidated by spectroscopic methods(1D,2D NMR,UV,IR,[α]D,and HRESI-TOF-MS)and chemical analyses.Results Twenty saponins including 20(S)-ginsenoside Rh1(1),6-O-β-D-(6′-acetyl)-glucopyranosyl-24-ene-dammar-3β,6α,12β,20S-tetraol(2),ginseno-side Rf(3),notoginsenoside R2(4),ginsenoside Rg2(5),ginsenoside Rg1(6),notoginsenoside Rt(7),koryoginsenoside R1(8),6-O-(β-D-glucopyranosyl)-20-O-(β-D-xylopyranosyl)-3β,6α,12β,20(S)-tetrahydroxy-dammar-24-ene(9),pseudoginsenoside Rt3(10),notoginsenoside R1(11),ginsenoside Re(12),notoginsenoside N(13),ginsenoside F1(14),ginsenoside U(15),ginsenoside Rk3(16),3β,12β-dihydroxydammar-(E)-20(22),24-diene-6-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside(17),ginsenoside Rh4(18),pseudoginsenoside Rt5(19),and vinaginsenoside R22(20)were obtained.Conclusion Compounds 2,19,and 20 are isolated from this species for the first time.The 1H-NMR data of compound 19 and1H-NMR and 13C-NMR data of compound 20 are first reported.Meanwhile,the NMR data ofβ-D-xylopyranosyl group in compound 9 is corrected. | Li-feng Han Kaunda Joseph Sakah Li-li Liu Agyemang Kojo Tao Wang Yi Zhang | 2014 | Chinese Herbal Medicines2014，6，2： | 13 |
| 2 | 火绒草化学成分的分离与鉴定(Ⅲ)显示文摘目的对火绒草的化学成分进行研究,为进一步开发利用该植物资源提供依据。方法采用正相硅胶、反相ODS、Sephadex LH 20等柱色谱以及高效液相色谱法等手段进行分离纯化,并通过理化性质与光谱分析鉴定化合物的结构。结果从火绒草体积分数为70%的乙醇溶液提取物中又分离鉴定了8个单体成分,分别为木犀草素(luteolin,1)、山柰酚3 O(4″O乙酰基6″O反式对香豆酰基)βD吡喃葡萄糖苷(kaempferol-3-O-(4″-O-acetyl-6″-O-trans-p-coumaroyl)-β-D-glucopyranoside,2)、槲皮素(quercetin,3)、槲皮素3 O(6″O反式对香豆酰基)βD吡喃葡萄糖苷(quercetin-3-O-(6″-O-trans-p-coumaroyl)-β-D-glucopyranoside,4)、(7R,8S)-dihydrodehydrodi-coniferyl alcohol 4-O-β-D-glucopyranoside(5)、(7S,8R)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(6)、everiastoside L(7)及松柏苷(coniferin,8)。结论化合物1和3为首次该种中分离得到,2、4 8为首次从火绒草属植物中分离得到。 | 陈秋 王涛 吴春华 Kaunda Joseph Sakah 韩立峰 张祎 | 2013 | 沈阳药科大学学报2013，30，3： | 8 |
| 3 | Eight darmarane-type saponins isolated from the roots of Panax notoginseng显示文摘Eight darmarane-type saponins,named as sanchirhinoside D(1),3β,6 α-20(S)-6,20-bis(β-D-glucopyranosyloxy)-3-hydroxy dammar-24-en-12-one(2),20(R)-ginsenoside Rg3(3),ginsenosides F2(4)and Rd(5),gypenoside XVII(6),ginsenosides Rb1(7)and ginsenoside V(8)were isolated from the 70%ethanol extract of Panax notoginseng roots by silica gel,octadecyl silane(ODS)column chromatography and HPLC,and identified by chemical and physical methods,especially by spectral analysis.Among them,1 was a new compound and 2 was a new natural product. | Kaunda Joseph Sakah Tao Wang Lili Liu Yue Chen Lifeng Han Yi Zhang | 2013 | Acta Pharmaceutica Sinica B2013，3，6： | 3 |
| 4 | The Genus Solanum:An Ethnopharmacological,Phytochemical and Biological Properties Review显示文摘Over the past 30 years,the genus Solanum has received considerable attention in chemical and biological studies.Solanum is the largest genus in the family Solanaceae,comprising of about 2000 species distributed in the subtropical and tropical regions of Africa,Australia,and parts of Asia,e.g.,China,India and Japan.Many of them are economically signifcant species.Previous phytochemical investigations on Solanum species led to the identifcation of steroidal saponins,steroidal alkaloids,terpenes,favonoids,lignans,sterols,phenolic comopunds,coumarins,amongst other compounds.Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to diferent tumors as breast cancer(4T1 and EMT),colorectal cancer(HCT116,HT29,and SW480),and prostate cancer(DU145)cell lines.The biological activities have been attributed to a number of steroidal saponins,steroidal alkaloids and phenols.This review features 65 phytochemically studied species of Solanum between 1990 and 2018,fetched from SciFinder,Pubmed,ScienceDirect,Wikipedia and Baidu,using“Solanum”and the species’names as search terms(“all felds”). | Joseph Sakah Kaunda Ying-Jun Zhang | 2019 | Natural Products and Bioprospecting2019，9，2： | 2 |
| 5 | Three-dimensionalobservation of pulp cavites in the maxillary first premolar tooth using micro-CT 显示文摘 | OiT SakaH IdeY | 2004 | Int Endod J2004，37，： | 1 |
| 6 | Two New Phenolic Constituents from the Stems of Euphorbia griffithii显示文摘Phytochemical studies on MeOH extract of stems of Euphorbia griffithii led to the isolation of one new hydrolyzable tannin dimer,corilagiffithiin(1)and one new galloyl-glucoside(2),alongside six known ones(3-8).Their structures and absolute configurations were determined by in depth spectroscopic analyses and comparison of their 1D NMR and MS data with literature reported values.Configurations of sugar moieties were determined by acidic hydrolysis and subsequent GC analysis of their corresponding trimethylsilylated l-cysteine adduct.At a concentration of 50μM,compounds 1-3 showed no anti-inflammatory activities. | Joseph Sakah Kaunda Ying-Jun Zhang | 2019 | Natural Products and Bioprospecting2019，9，6： | 1 |
| 7 | The Genus Carissa:An Ethnopharmacological,Phytochemical and Pharmacological Review显示文摘Carissa L.is a genus of the family Apocynaceae,with about 36 species as evergreen shrubs or small trees native to tropical and subtropical regions of Africa,Asia and Oceania.Most of Carissa plants have been employed and utilized in traditional medicine for various ailments,such as headache,chest complains,rheumatism,oedema,gonorrhoea,syphilis,rabies.So far,only nine Carissa species have been phytochemically studied,which led to the identification of 123 compounds including terpenes,flavonoids,lignans,sterols,simple phenolic compounds,fatty acids and esters,and so on.Pharmacological studies on Carissa species have also indicated various bioactive potentials.This review covers the peer-reviewed articles between 1954 and 2016,retrieved from Pubmed,ScienceDirect,SciFmder,Wikipedia and Baidu,using“Carissa”as search term(“all fields”)and with no specific time frame set for search.Fifteen important medicinal or ornamental Carissa species were selected and summarized on their botanical characteristics,geographical distribution,traditional uses,phytochemistry,and pharmacological activities. | Joseph Sakah Kaunda Ying-Jun Zhang | 2017 | Natural Products and Bioprospecting2017，7，2： | 0 |
| 8 | The Genus Terminalia(Combretaceae):An Ethnopharmacological,Phytochemical and Pharmacological Review显示文摘Terminalia Linn,a genus of mostly medium or large trees in the family Combretaceae with about 250 species in the world,is distributed mainly in southern Asia,Himalayas,Madagascar,Australia,and the tropical and subtropical regions of Africa.Many species are used widely in many traditional medicinal systems,e.g.,traditional Chinese medicine,Tibetan medicine,and Indian Ayurvedic medicine practices.So far,about 39 species have been phytochemically studied,which led to the identification of 368 compounds,including terpenoids,tannins,flavonoids,phenylpropanoids,simple phenolics and so on.Some of the isolates showed various bioactivities,in vitro or in vivo,such as antitumor,anti HIV-1,antifungal,antimicrobial,antimalarial,antioxidant,diarrhea and analgesic.This review covers research articles from 1934 to 2018,retrieved from SciFinder,Wikipedia,Google Scholar,Chinese Knowledge Network and Baidu Scholar by using“Terminalia”as the search term(“all fields”)with no specific time frame setting for the search.Thirty-nine important medicinal and edible Terminalia species were selected and summarized on their geographical distribution,traditional uses,phytochemistry and related pharmacological activities. | Xiao-Rui Zhang Joseph Sakah Kaunda Hong-Tao Zhu Dong Wang Chong-Ren Yang Ying-Jun Zhang | 2019 | Natural Products and Bioprospecting2019，9，6： | 0 |
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