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| 1 | Inflammatory bowel disease and thromboembolism显示文摘Patients with inflammatory bowel disease(IBD) have an increased risk of vascular complications. Thromboembolic complications,both venous and arterial,are serious extraintestinal manifestations complicating the course of IBD and can lead to significant morbidity and mortality. Patients with IBD are more prone to Thromboembolic complications and IBD per se is a risk factor for thromboembolic disease. Data suggest that thrombosis is a specific feature of IBD that can be involved in both the occurrence of thromboembolic events and the pathogenesis of the disease. The exact etiology for this special association between IBD and thromboembolism is as yet unknown,but it is thought that multiple acquired and inherited factors are interacting and producing the increased tendency for thrombosis in the local intestinal microvasculature,as well as in the systemic circulation. Clinicians' awareness of the risks,and their ability to promptly diagnose and manage TEs are of vital importance. In this review we discuss how thromboembolic disease is related to IBD,specifically focusing on:(1) the epidemiology and clinical features of thromboembolic complications in IBD;(2) the pathophysiology of thrombosis in IBD;and(3) strategies for the prevention and management of thromboembolic complications in IBD patients. | Petros Zezos Georgios Kouklakis Fred Saibil | 2014 | World Journal of Gastroenterology2014，20，38： | 12 |
| 2 | Physiological and radiographic assessment during the development of pulmonary radiation fibrosis 显示文摘 | Prato FS Kurdyak R Saibil EA | 1977 | Radiology1977，122，2： | 1 |
| 3 | Activation of the GTP-binding protein Gq by rhodopsin in squid photoreceptor显示文摘 | NOBES C BAVERSTOCK J SAIBIL H | 1992 | Biochemical Journal1992，287，： | 1 |
| 4 | ATP-induced large quaternary rearrangements in a cage-like chaperonin structure显示文摘 | Saibil H R Zheng D Roseman A M | 1993 | Curr Biol1993，3，5： | 1 |
| 5 | A small heat shock protein stably binds heat-denatured model substrates and can maintain a sub- strate in a foldingcompetent state 显示文摘 | Lee GJ Roseman AM Saibil HR | 1997 | EMBO J1997，16，3： | 1 |
| 6 | A small heat shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding-competent state显示文摘 | Garrett J Lee Alan M Roseman Helen R Saibil | 1997 | The EMBO Joumal1997，16，3： | 1 |
| 7 | Incidence of taxane-induced pain and distress in patients receiving chemotherapy for early-stage breast cancer:a retrospective,outcomes-based survey显示文摘 | Saibil S PhD MD Fitzgerald B | 2010 | Curr Oncol2010，17，4： | 1 |
| 8 | Chaperone machines in action显示文摘 | Saibil HR | | 0，，： | 1 |
| 9 | Chaperone machines for protein folding, unfol- ding and disaggregation 显示文摘 | Saibil H | 2013 | Nature Reviews Molecular Cell Biology2013，14，10： | 1 |
| 10 | The protective effect of gamma-hydroxybutyrate in regional intestinal ischemia in the hamster显示文摘 | Boyd AJ Sherman IA Saibil FG | 1990 | Gastroenterology1990，99，3： | 1 |
| 11 | Effects of calcium on light-activated GTP-binding proteins in squid photoreceptor menbranes显示文摘 | FYLES J M BAVERSTOCK J BAER K SAIBIL H R | 1991 | Compar Biochem and Physiol1991，98，： | 1 |
| 12 | gamma-Hydroxybutyrate mediated protection of liver function after long-term hypothermic storage显示文摘 | Sherman IA Saibil FG Janossy TI | 1994 | Transplantation1994，57，1： | 1 |
| 13 | The cardiovascular effects of gamma-hydroxybutyrate following hemorrhage显示文摘 | Boyd AJ Sherman IA Saibil FG | 1992 | Circ Shock1992，38，2： | 1 |
| 14 | A randomized trial of aspirin to prevent colorectal adenomas显示文摘 | Baron JA Cole BF Sandler RS Haile RW Ahnen D Bresalier R McKeown-Eyssen G Summers RW Rothstein R Burke CA Snover DC Church TR Allen JI Beach M Beck GJ Bond JH Byers T Greenberg ER Mandel JS Marcon N Mott LA Pearson L Saibil F van Stolk RU | 2003 | N Engl J Med2003，348，10： | 1 |
| 15 | A small heat shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding competent state 显示文摘 | Lee GJ Roseman AM Saibil HR | 1997 | EMBO J1997，16，： | 1 |
| 16 | Chaperone machines in action显示文摘 | Saibil H R | 2008 | Curr Opin Struc Biol2008，18，1： | 1 |
| 17 | Molecular chaperones:containers and surfsces for folding,stabilizing or unfolding proteins显示文摘 | SAIBIL H | 2000 | Curr Opin Struct Boil2000，10，2： | 1 |
| 18 | Structural basis for the regulated protease and chaperone function of DegP显示文摘 | Krojer T Sawa J Schfer E Saibil HR Ehrmann M Clausen T | 2008 | Nature2008，453，7197： | 1 |
| 19 | RIP2 contributes to Nod sig- naling but is not essential for T cell proliferation, T helper differentia- tion or TLR responses显示文摘 | Hall HT Wilhelm MT Saibil SD | 2008 | Eur J Immunol2008，38，1： | 1 |
| 20 | Chaperone machines for protein foldlng,unfolding and disaggregation显示文摘 | SAIBIL H | 2013 | Nature Reviews Molecular Cell Biology2013，14，10： | 1 |
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