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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Advances in surgical management for locally recurrent rectal cancer: How far have we come?显示文摘Locally recurrent rectal cancer(LRRC) is a complex disease with far-reaching implications for the patient. Until recently, research was limited regarding surgical techniques that can increase the ability to perform an en bloc resection with negative margins. This has changed in recent years and therefore outcomes for these patients have improved. Novel radical techniques and adjuncts allow for more radical resections thereby improving the chance of negative resection margins and outcomes. In the past contraindications to surgery included anterior involvement of the pubic bone, sacral invasions above the level of S2/S3 and lateral pelvic wall involvement. However, current data suggests that previously unresectable cases may now be feasible with novel techniques, surgical approaches and reconstructive surgery. The publications to date have only reported small patient pools with the research conducted by highly specialised units. Moreover, the short and long-term oncological outcomes are currently under review. Therefore although surgical options for LRRC have expanded significantly, one should balance the treatment choices available against the morbidity associated with the procedure and select the right patient for it. | Daniel Jin-Keat Lee Peter M Sagar Gaitri Sadadcharam Kok-Yang Tan | 2017 | World Journal of Gastroenterology2017，23，23： | 12 |
| 3 | Defferential regulation of connexin 43 and connexin37 in endothelial cills by cell density,growth,and TGF -β1显示文摘 | Larson DM Wrobleski M J Sagar GDV | 1997 | Am J Physiol Cell Physiol1997，272，： | 1 |
| 4 | Vasoactive intestinal polypeptide (VIP)immunohistochemistry in the rabbit retina显示文摘 | SAGAR S M | 1987 | Brain Res1987，426，1： | 1 |
| 5 | Light regulates expression of a Fos-related protein in the rat SCN显示文摘 | Aronin N Sagar S M Sharp F R | 1990 | Proc Natl Acad Sci USA1990，87，15： | 1 |
| 6 | Surgical management of locally recurrent rectal cancer显示文摘 | Sagar P M Pemberton J H | 1996 | Br J Surg1996，83，3： | 1 |
| 7 | Surgical management of locally recurrent rectal cancer 显示文摘 | Sagar P M Pemberton J H | 1996 | Br J Surg1996，83，3： | 1 |
| 8 | Characterization of the day-night variation of retinal melatonin content in the chick 显示文摘 | REPPERT S M SAGAR S M | 1983 | Invest Ophthalmol Vis Sci1983，24，3： | 1 |
| 9 | Effect of CYP2C19 polymorphism on serum levels of vitamin BI2 in patients on long-term omeprazole treatment 显示文摘 | Sagar M Janczewska I Ljungdahl A | 1999 | Aliment Pharmacol ther1999，13，4： | 1 |
| 10 | Nitric oxide and anti-cancer therapy显示文摘 | Sagar s M Singh G Hodson DI | | 0，，02： | 1 |
| 11 | Expression of c-Fos protein in brain:metabolic mapping at the cellular level显示文摘 | Sharp F R Curran T | 1988 | Science1988，240，： | 1 |
| 12 | Evaluation of a multiplex reverse transcription polymerase chain reaction assay for subtyping hemagglutinin genes 1 and 3 of swine influenza type A virus in clinical samples显示文摘 | Young K C Sagar M G Han S J | 2002 | J Vet Diagn Invest2002，14，： | 1 |
| 13 | Thoracic lymphadenopathy in HIV pa- tients: spectrum of disease and differential diagnosis显示文摘 | Fishman JE Sagar M | 1999 | AIDS Pa tient Care STDS1999，13，11： | 1 |
| 14 | Immunopathogenesis of Takayasu arteritis显示文摘 | Sagar S Ganguly NK Koicha M | 1992 | Heart Vessels Suppl1992，7，： | 1 |
| 15 | Effects of omeprazole on intragastric pH and plasma gastrin are dependent on the CYP2C19 polymorphism显示文摘 | Sagar M Tybring G Dahl ML | 2000 | Gastroenterolog2000，119，3： | 1 |
| 16 | Interphenotype differences in disposition and effect on gastrin levels of omeprazole-suitability of omeprazole as a probe for CYP2C19显示文摘 | Tybring G Dahl ML Gotharson E Sagar M Seensalu R | 1995 | Br J Clin Pharmacol1995，39，5： | 1 |
| 17 | C-3 alkyl/arylalkyl-2,3 dideoxy hex 2-enopyranosides as antitubercular agents: Synthesis, biological evaluation, and QSAR study显示文摘 | Saquib M Gupta M K Sagar R | 2007 | J Med Chem2007，50，29： | 1 |
| 18 | Cooperation of p53 loss of founc tion and V-Ha-ras in transtormation of mouse keratinocyte cell lines显示文摘 | Azzoli CG Sagar M Wu A | 1998 | Mol Carcinog1998，21，1： | 1 |
| 19 | Influence of pH value on the quality of sol-gel derived ZnO films 显示文摘 | SAGAR P SHISHODIA P K MEHRA R M | 2007 | Appl Surf Sci2007，253，： | 1 |
| 20 | Cysteamine effects on growth hormone secretion in the male rats显示文摘 | MILLARD W J SAGAR S M BADGER T M | 1983 | Endocrinology1983，112，2： | 1 |
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