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| 1 | ABCD^(2) risk score does not predict the presence of cerebral microemboli in patients with hyper-acute symptomatic critical carotid artery stenosis显示文摘Introduction:ABCD^(2) risk score and cerebral microemboli detected by transcranial Doppler(TCD)have been separately shown to the predict risk of recurrent acute stroke.We studied whether ABCD2 risk score predicts cerebral microemboli in patients with hyper-acute symptomatic carotid artery stenosis.Participants and methods:We studied 206 patients presenting within 2 weeks of transient ischaemic attack or minor stroke and found to have critical carotid artery stenosis(≥50% ).86 patients(age 70±1(SEM:years),58 men,83 Caucasian)had evidence of microemboli;72(84% )of these underwent carotid endarterectomy(CEA).120 patients(age 72±1 years,91 men,113 Caucasian)did not have microemboli detected;102(85% )of these underwent CEA.Data were analysed using X2 and Mann–Whitney U tests and receiver operating characteristic(ROC)curves.Results:140/206(68% :95% CI 61.63 to 74.37)patients with hyper-acute symptomatic critical carotid stenosis had an ABCD2 risk score≥4.There was no significant difference in the NICE red flag criterion for early assessment(ABCD^(2) risk score≥4)for patients with cerebral microemboli versus those without microemboli(59/86 vs 81/120 patients:OR 1.05 ABCD2 risk score≥4(95% CI 0.58 to 1.90,p=0.867)).The ABCD2 risk score was<4 in 27 of 86(31% :95% CI 21 to 41)embolising patients and in 39 of 120(31% :95% CI 23 to 39)without cerebral microemboli.After adjusting for pre-neurological event antiplatelet treatment(APT),area under the curve(AUC)of ROC for ABCD2 risk score showed no prediction of cerebral microemboli(no pre-event APT,n=57:AUC 0.45(95% CI 0.29 to 0.60,p=0.531);preevent APT,n=147:AUC 0.51(95% CI 0.42 to 0.60,p=0.804)).Conclusions:The ABCD2 score did not predict the presence of cerebral microemboli or carotid disease in over one-quarter of patients with symptomatic critical carotid artery stenosis.On the basis of NICE guidelines(refer early if ABCD2≥4),assessment of high stroke risk based on ABCD2 scoring may lead to inappropriate delay in urgent treatment in many patients. | Mahmud Saedon Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2017 | Stroke & Vascular Neurology2017，2，2： | 6 |
| 2 | Is there a changing trend in surgical management of gastroesophageal reflux disease in children?显示文摘Gastroesophageal reflux disease (GORD) is a pathological process in infants manifesting as poor weight gain, signs of esophagitis, persistent respiratory symptoms and changes in neurobehaviour. It is currently estimated that approximately one in every 350 children will experience severe symptomatic gastroesophageal reflux necessitating surgical treatment. Surgery for GORD is currently one of the common major operations performed in infants and children. Most of the studies found favour laparoscopic approach which has surpassed open antireflux surgery as the gold standard of surgical management for GORD.However, it must be interpreted with caution due to the limitation of the studies, especially the small number of subject included in these studies. This review reports the changing trends in the surgical treatment of GORD inchildren. | Mahmud Saedon Stavros Gourgiotis Stylianos Germanos | 2007 | World Journal of Gastroenterology2007，13，33： | 2 |
| 3 | Determinants of mortality among older adults with pressure ulcers 显示文摘 | Khor HM Tan J Saedon NI | 2014 | Arch Gerentol Geriatr2014，59，3： | 1 |
| 4 | Registry report on kinetics of rescue antiplatelet treatment to abolish cerebral microemboli after carotid endarterectomy显示文摘 | Saedon M Singer DR Pang R | 2013 | Stroke2013，44，： | 1 |
| 5 | Temporal artery biopsy for giant cell arteritis:retrospective audit显示文摘 | Saedon H Saedon M Goodyear S | | 0，，： | 1 |
| 6 | Perioperative transorbital Doppler flow imaging offers an alternative to transcranial Doppler monitoring in those patients without a temporal bone acoustic window显示文摘 | Jaipersad TS Saedon M Tiivas C | 2011 | Ultrasound in Med & Biol2011，5，37： | 1 |
| 7 | Post-thrombotic syndrome: prevention is better than cure 显示文摘 | Saedon M Stanshy G | 2010 | Phlebology2010，25，1： | 1 |
| 8 | Registry report on ki- netics of rescue antiplatelet treatment to abolish cerebral mi- croemboli after carotid endarterectomy 显示文摘 | Saedon M Singer DR Pang R | 2013 | Stroke2013，44，1： | 1 |
| 9 | Detenrminants of mortality amorg older adults with pressure ulcers 显示文摘 | Klor HM Tan J Saedon NI | 2014 | Arch Gerontol Geriaatr2014，59，3： | 1 |
| 10 | Determinants of mortality among older aduhs with pressure ulcers显示文摘 | Khor HM Tan J Saedon NI | 2014 | Arch Gerontol Geriatr2014，59，3： | 1 |
| 11 | Post-thrombotic syndrome: prevention is bet- ter than cure 显示文摘 | Saedon M Stansby G | 2010 | Phlebology2010，25，1： | 1 |
| 12 | Prospective validation study of transorbital Doppler ultrasound imaging for the detection of transient 显示文摘 | Saedon M Dilshad A Tiivas C | 2014 | Br J Surg2014，101，12： | 1 |
| 13 | Perioperative transorbital Doppler flow imaging offers an alternative to transcranial Doppler monitoring in those patients without a temporal bone acoustic window 显示文摘 | Jaipersad TS Saedon M Tiivas C | 2011 | Ultrasound Med Biol2011，37，5： | 1 |
| 14 | Post-thrombotic syndrome:prevention is better than cure显示文摘 | Saedon M Stansby G | 2010 | Phlebology2010，25，1： | 1 |
| 15 | Registry report on prediction by Pocock cardiovascular score of cerebral microemboli acutely following carotid endarterectomy显示文摘background Cerebral microemboli may lead to ischaemic neurological complications after carotid endarterectomy(CEA).The association between classical cardiovascular risk factors and acute cerebral microemboli following carotid surgery has not been studied.The aim of this study was to explore whether an established cardiovascular risk score(Pocock score)predicts the presence of cerebral microemboli acutely after CEA.subjects and methods Pocock scores were assessed for the 670 patients from the Carotid Surgery Registry(age 71±1(SEM)years,474(71%)male,652(97%)Caucasian)managed from January 2002 to December 2012 in the Regional Vascular Centre at University Hospitals Coventry and Warwickshire NHS Trust,which serves a population of 950000.CEA was undertaken in 474(71%)patients for symptomatic carotid stenosis and in 196(25%)asymptomatic patients during the same period.74% of patients were hypertensive,71%were smokers and 49% had hypercholesterolaemia.results A high Pocock score(≥2.3%)was significantly associated with evidence of cerebral microemboli acutely following CEA(P=0.039,Mann-Whitney(MW)test).A Pocock score(≥2.3%)did not predict patients who required additional antiplatelet therapy(microemboli signal(MES)rate>50 hour-1:P=0.164,MW test).Receiver operating characteristic analysis also showed that the Pocock score predicts acute postoperative microemboli(area under the curve(AUC)0.546,95%CI 0.502 to 0.590,P=0.039)but not a high rate of postoperative microemboli(MES>50 hour−1:AUC 0.546,95% CI 0.482 to 0.610,P=0.164).A Pocock score≥2.3% showed a sensitivity of 74% for the presence of acute postoperative cerebral microemboli.A Pocock score≥2.3% also showed a sensitivity of 77% and a negative predictive value of 90% for patients who developed a high microembolic rate>50 hour−1 after carotid surgery.Conclusion These findings demonstrate that the Pocock score could be used as a clinical tool to identify patients at high risk of developing acute postoperative microemboli. | Mahmud Saedon Athanasios Saratzis Rachel W S Lee Charles E Hutchinson Christopher H E Imray Donald R J Singer | 2018 | Stroke & Vascular Neurology2018，3，3： | 1 |
| 16 | Perioperative transorbital Doppler flow imaging offers an alternative to transcranial Doppler monitoring in those patients without a temporal bone acoustic window 显示文摘 | Jaipersad TS Saedon M Tiivas C | 2011 | Ultrasound Med Biol2011，37，5： | 1 |
| 17 | 颈动脉术后急性脑微栓子高危患者识别工具——Pocock心血管评分显示文摘Stroke & Vascular Neurology(SVN)2018年发表文章“Registry report on prediction by Pocock cardiovascular score of cerebral microemboli acutely following carotid endarterectomy”,由来自英国诺丁汉大学医院、英国考文垂和沃里克大学医院国家医疗服务体系信托基金的Mahmud Saedon执笔,美国耶鲁大学医学院 Donald R J Singer教授及其团队成员共同参与完成[1]。 | SAEDON M SARATZIS A LEE R W S | 2019 | 中国卒中杂志2019，14，6： | 0 |
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