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31篇 您的检索式:作者名="Sadowitz"
    题名 作者 年代 出处 被引量
1Preemptive mechanical ventilation can block progressive acute lung injury显示文摘Mortality from acute respiratory distress syndrome(ARDS) remains unacceptable, approaching 45% in certain high-risk patient populations. Treating fulminant ARDS is currently relegated to supportive care measures only. Thus, the best treatment for ARDS may lie with preventing this syndrome from ever occurring. Clinical studies were examined to determine why ARDS has remained resistant to treatment over the past several decades. In addition, both basic science and clinical studies were examined to determine the impact that early, protective mechanical ventilation may have on preventing the development of ARDS in at-risk patients. Fulminant ARDS is highly resistant to both pharmacologic treatment and methods of mechanical ventilation. However, ARDS is a progressive disease with an early treatment window that can be exploited. In particular, protective mechanical ventilation initiated before the onset of lung injury can prevent the progression to ARDS. Airway pressure release ventilation(APRV) is a novel mechanical ventilation strategy for delivering a protective breath that has been shown to block progressive acute lung injury(ALI) and prevent ALI from progressing to ARDS. ARDS mortality currently remains as high as 45% in some studies. As ARDS is a progressive disease, the key to treatment lies with preventing the disease from ever occurring while it remains subclinical. Early protective mechanical ventilation with APRV appears to offer substantial benefit in this regard and may be the prophylactic treatment of choice for preventing ARDS.Benjamin Sadowitz Sumeet Jain Michaela Kollisch-Singule Joshua Satalin Penny Andrews Nader Habashi Louis A Gatto Gary Nieman 2016World Journal of Critical Care Medicine2016,5,1:9
2Statin therapy-Part I:The pleiotropic effects of statins in cardiovascular disease显示文摘Sadowitz B Maier KG Gahtan V 2010Vasc Endovascular Surg2010,44,4:1
3Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing- based ventilatory intervention to avert lung injury 显示文摘Roy S Sadowitz B Andrews P 2012J Trauma Acute Care Surg2012,73,2:1
4Lunginjury induced by sepsis : lessons learned from largeanimal models and future directories for treatment 显示文摘SADOWITZ B ROY S GATTO L A 2011Expert Rev Anti Infect Ther2011,9,12:1
5Iron Status and infant feeding practices in an urban ambulatory center显示文摘Sadowitz PD Oski FA 1983Pediatrics1983,72,1:1
6Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment 显示文摘Sadowitz B Roy S Gatto LA 2011Expert Rev Anti Infect Ther2011,9,12:1
7Jack of all trades: pleiotropy and the application of chemically modified tetracycline-3 in sepsis and the acute respiratory distress syndrome (ARDS)显示文摘ROY S K KENDRICK D SADOWITZ B D 2011Pharmaeol Res2011,64,6:1
8Preemptive application of airwaypressure release ventilation prevents development of acute respiratorydistress syndrome in a rat traumatic hemorrhagic shock model 显示文摘Roy SK Emr B Sadowitz B 2013Shock2013,40,3:1
9Lung injury induced by sepsis:lessons learned from large animal models and future directions for treatment显示文摘Sadowitz B Roy S Gatto LA 0,,12:1
10Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury显示文摘Roy S Habashi N Sadowitz B 2013Shock2013,39,1:1
11Jack of all trades: pleiotropy and the application of chemically modified tetracycline - 3 in sepsis and the acute respiratory distress syndrome (ARDS) 显示文摘Roy SK Kendriek D Sadowitz BD 2011Pharmacol Res2011,64,6:1
12Jack of all trades: Pleiotropy and the application of chemically modified tetracy- cline-3 in sepsis and the acute respiratory distress syndrome (ARDS)显示文摘Roy SK Kendrick D Sadowitz BD 2011Pharmacol Res2011,64,6:1
13Basic science review:statin therapy-Part I:the pleiotropic effects of statins incardiovascular disease显示文摘Sadowitz B Maier KG Gahtan V 2010Vasc Endovascular Surg2010,44,4:1
14Differential effect of nitric-oxide on thrombospondin-1 , PDGF- and fibronee- tin-induced migration of vascular smooth muscle cells显示文摘Seymour K Han X Sadowitz B 2010Am J Surg2010,200,5:1
15Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment 显示文摘Sadowitz B Roy S Gatto LA 2011Expert Rev Anti Infect Ther2011,9,12:1
16Thrombospondin- 1 induced vascular smooth muscle cell migration is de- pendent on the hyaluronic acid receptor CD44显示文摘Maier KG Sadowitz B Cullen S 2009Am J Surg2009,198,5:1
17Vascular smooth muscle cell migration induced by domains of throm bospondin-1 is differentially regulated显示文摘Seymour KA Sadowitz B Stein JJ 2011Am J Surg2011,202,5:1
18The role of hyaluronic acid in atherosclerosis and intimal hyperplasia 显示文摘Sadowitz B Seymour K Gahtan V 2012J Surg Res2012,173,2:1
19Treatment of late bone marrow relapse in children with acute lymphoblastic leukemia: a Pediatric Oncology Group Study 显示文摘SADOWITZ PD SMITH SD SHUSTER J 1993Blood1993,81,3:1
20Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment显示文摘Sadowitz B Roy S Gatto LA 2011Expert Rev Anti Infect Ther2011,9,12:1
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