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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | Thoracic paravertebral block-ade 显示文摘 | Bond6r A Szucs S Iohom G | 2010 | Med Ultrason2010，12，3： | 1 |
| 3 | Simultaneous determination of styrene,toluene,and xylene,metabolites in urine by gas chromatography/mass spectrometry显示文摘 | SZUCS S TOTH L LEGOZA J | 2002 | Toxicokinetics and Metabolism2002，76，： | 1 |
| 4 | Analysisofphospholipids in lecithins:comparison between micellar-electrokinetic chromatography and high-performance hquid chromatography 显示文摘 | Szucs R VerleysenK DuchateauG S M J E | 1996 | J Chromatogr A1996，738，： | 1 |
| 5 | Interferon-γ-induced sensitization of colon carcinomas to ZD9331 targets caspases,downstream of Fas,independent of mitochondrial signaling and the inhibitor of apoptosis survivin显示文摘 | Geller J Petak I Szucs K S | 2003 | Clin Cancer Res2003，9，17： | 1 |
| 6 | Democratization and the Reorganization of the Wel- fare State显示文摘 | SZUCS S | 1995 | The ANNALS of the American Academy of Po- litical and Social Science1995，，540： | 1 |
| 7 | The seperation of the granulocytes from different rat strains 显示文摘 | Szucs S Varga C Ember I | 1994 | J Immunol Methods1994，167，： | 1 |
| 8 | Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methioninesynthase (MTRR) inethnic populations in Texas:a report of a novelMTHFR polymorphic site,G1793A显示文摘 | Rady P L Szucs S Grady J | 2002 | J Am J M ed Genet2002，107，1： | 1 |
| 9 | Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) in ethnic populations in Texas; a report of a novel MTHFR polymorphic site, G1793A 显示文摘 | Rady PL Szucs S Grady J | 2002 | Am J Med Genet2002，107，2： | 1 |
| 10 | Analysis of risk factors-especially different types of plexitis-for postoperative relapse in Crohn's disease显示文摘AIM To evaluate the presence of submucosal and myenteric plexitis and its role in predicting postoperative recurrence.METHODS Data from all patients who underwent Crohn's disease(CD)-related resection at the University of Szeged, Hungary between 2004 and 2014 were analyzed retrospectively. Demographic data, smoking habits, previous resection, treatment before and after surgery, resection margins, neural fiber hyperplasia, submucosal and myenteric plexitis were evaluated as possible predictors of postoperative recurrence. Histological samples were analyzed blinded to the postoperative outcome and the clinical history of the patient. Plexitis was evaluated based on the appearance of the most severely inflamed ganglion or nerve bundle. Patients underwent regular follow-up with colonoscopy after surgery. Postoperativerecurrence was defined on the basis of endoscopic and clinical findings, and/or the need for additional surgical resection. RESULTS One hundred and four patients were enrolled in the study. Ileocecal, colonic, and small bowel resection were performed in 73.1%, 22.1% and 4.8% of the cases, respectively. Mean disease duration at the time of surgery was 6.25 years. Twenty-six patients underwent previous CD-related surgery. Forty-three point two percent of the patients were on 5-aminosalicylate, 20% on corticosteroid, 68.3% on immunomodulant, and 4% on anti-tumor necrosis factor-alpha postoperative treatment. Postoperative recurrence occurred in 61.5% of the patients; of them 39.1% had surgical recurrence. 92.2% of the recurrences developed within the first five years after the index surgery. Mean disease duration for endoscopic relapse was 2.19 years. The severity of submucosal plexitis was a predictor of the need for second surgery(OR = 1.267, 95%CI: 1.000-1.606, P = 0.050). Female gender(OR = 2.21, 95%CI: 0.98-5.00, P = 0.056), stricturing disease behavior(OR = 3.584, 95%CI: 1.344-9.559, P = 0.011), and isolated ileal localization(OR = 2.671, 95%CI: 1.033-6.910, P = 0.043) were also predictors of postoperative recurrence. No association was revealed between postoperative recurrence and smoking status, postoperative prophylactic treatment and the presence of myenteric plexitis and relapse.CONCLUSION The presence of severe submucosal plexitis with lymphocytes in the proximal resection margin is more likely to result in postoperative relapse in CD. | Agnes Milassin Anita Sejben László Tiszlavicz Zita Reisz Gyorgy Lázár Mónika Szucs Renáta Bor Anita Bálint Mariann Rutka Zoltán Szepes Ferenc Nagy Klaudia Farkas Tamás Molnár | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 1 |
| 11 | High level of oxerin A observed in the phenylketonuria mouse brain is due to the abnormal expression of prepro-oxerin显示文摘 | Surendran S Rady PL Szucs S | 2004 | Biochem Biophys Res Commun2004，317，2： | 1 |
| 12 | Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis 显示文摘 | SZUCS E RAVANDI S GOOSSENS A | 2002 | Am J Rhinol2002，16，： | 1 |
| 13 | Chemokines in rheumatic diseases显示文摘 | Szekanecz Z Szucs G Szanto S | 2006 | Curr Drug Targets2006，7，1： | 1 |
| 14 | Glucocorticosteroid dependent decrease in the activity of calcineurin in the peripheral blood mononuclear cells of patients with systemic lupus erythematosus显示文摘 | SIPKA S SZUCS K SZ(A)NT(O) S | 2001 | Ann Rheum Dis2001，60，4： | 1 |
| 15 | Motor conflict in Stroop tasks: Direct evidence from single-triM electro-myography and electro-encephalography 显示文摘 | Szucs D Sohesz F White S | 2009 | Neuroimage2009，47，4： | 1 |
| 16 | Eosinophilia in the ethmoid mucosa and its relationship to the severity of inflammation in chronic rhinosinusitis显示文摘 | Szucs E Ravandi S Goossens A | 2002 | Am J Rhinol2002，16，3： | 1 |
| 17 | Right lobe living donor liver transplantation- preoperative evaluation of the donor with MR imaging显示文摘 | Fulcher A S Szucs R A Bassignani M J | 2001 | American Journal of Roentgenology2001，176，6： | 1 |
| 18 | The separation of the granulocytes from different rat strains显示文摘 | Szucs S Varga C Ember I | | 0，，： | 1 |
| 19 | Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTRR) in ethnic populations in Texas: a report of a novel MTHFR polymorphic site, G1793A 显示文摘 | RADY P L SZUCS S GRADY J | 2002 | Am J Med Genet2002，107，： | 1 |
| 20 | Preparation of Pd^o nanoparticles stabilized by polymers and layered silicate显示文摘 | PAPP S SZUCS A DEKANY I | 2001 | Appl Clay Sci2001，19，： | 1 |
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